Fasciculations after rattlesnake envenomations: A retrospective statewide poison control system study

Vohra, Rais; Cantrell, F. Lee; Williams, Saralyn R.

doi:10.1080/15563650701638925

Cited by 21 publications

(19 citation statements)

References 6 publications

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“…The second treatment animal reached the endpoint of 420 min without any signs of systemic toxicity. The control group displayed significant myokymia (fasciculations) after envenomation, consistent with prior evidence that has linked myokymia to these bites and respiratory failure [22,23].…”

Section: Discussionsupporting

confidence: 83%

A Localizing Circumferential Compression Device Delayed Death After Artificial Eastern Diamondback Rattlesnake Envenomation to the Torso of an Animal Model in a Pilot Study

et al. 2010

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Nearly all prior studies to delay onset of systemic toxicity and death after snake bite use a model of distal extremity envenomation. In the first of a series of planned studies using snake venoms with different toxicity profiles, the application of a novel device in a new model of torso envenomation in the setting of Eastern Coral Snake (Micrurus fulvius) venom (a potent neurotoxin) envenomation showed promise by delaying systemic intoxication. In this pilot study, we investigated this novel localizing circumferential compression (LoCC) device's ability to delay onset of life threatening systemic toxicity after Eastern Diamondback Rattlesnake (Crotalus adamanteus) envenomation, a potent hemotoxic and myotoxic venom. With university approval, four juvenile female pigs (22-25 kg) were anesthetized, sedated, and intubated but not paralyzed to allow for spontaneous respirations. Each animal was injected subcutaneously with 50 mg of C. adamanteus venom in identical preselected areas of the trunk. After 1 min, two treatment animals had the LoCC device applied; two control animals had no intervention. Vital signs were recorded every 10 min for the first 2 h and every 30 min thereafter. Endpoints included cardiovascular collapse (fatal arrhythmia, loss of mean arterial pressure, or pulse) or respiratory arrest (<3 breaths/min, saturation < 80%) or survival to 7 h. The pigs in the treatment group reached an endpoint at an average time of 355 (+/-65) min compared with control 32 (+/-3.5) min (p < 0.04). In this pilot study, the LoCC device significantly delayed onset of systemic symptoms and death after torso envenomation with Eastern Diamondback Rattlesnake venom in this model.

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Section: Discussionsupporting

confidence: 83%

A Localizing Circumferential Compression Device Delayed Death After Artificial Eastern Diamondback Rattlesnake Envenomation to the Torso of an Animal Model in a Pilot Study

et al. 2010

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“…Voltage-gated potassium channels are widespread throughout the peripheral, autonomic, and central nervous systems and play a key role in controlling neuronal excitability (9). Peripheral nerve hyperexcitability may be immunological (10); genetic, such as in episodic ataxia/myokymia syndrome associated with mutations in the human potassium channel gene, KCNA1 (11); toxic, as in the case of rattlesnake envenomation (12); and pharmacological in response to drugs, such as flunarizine (3), clozapine (4), and gold salts (5).…”

Section: Discussionmentioning

confidence: 99%

Eyelid myokymia in patients with migraine taking topiramate

et al. 2015

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“…Other venom components may cause muscle fasciculations by interfering with calcium binding on the nerve membrane. 7,17,18 CROTALIDAE POLYVALENT IMMUNE FAB ANTIVENOM (OVINE ORIGIN)…”

Section: Crotaline Venom Toxicitymentioning

confidence: 99%

Crotalidae Polyvalent Immune Fab for the Treatment of Pediatric Crotaline Envenomation

Goto

Feng

2009

Pediatric Emergency Care

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Crotaline snakebites occur frequently in children, often resulting in significant morbidity. Crotalidae Polyvalent Immune Fab antivenom (FabAV) became available for clinical use in the US in 2000 and is currently the standard of care for the treatment of crotaline envenomation. The pediatric emergency care provider should be familiar with FabAV because its judicious use in affected children can greatly decrease morbidity caused by crotaline snakebites. This article will review the use of FabAV for the treatment of pediatric crotaline envenomation.

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Fasciculations after rattlesnake envenomations: A retrospective statewide poison control system study

Cited by 21 publications

References 6 publications

A Localizing Circumferential Compression Device Delayed Death After Artificial Eastern Diamondback Rattlesnake Envenomation to the Torso of an Animal Model in a Pilot Study

A Localizing Circumferential Compression Device Delayed Death After Artificial Eastern Diamondback Rattlesnake Envenomation to the Torso of an Animal Model in a Pilot Study

Eyelid myokymia in patients with migraine taking topiramate

Crotalidae Polyvalent Immune Fab for the Treatment of Pediatric Crotaline Envenomation

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