Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode

Delgado‐Martínez, Ignacio; Righi, Martina; Santos, Daniela Soares; Cutrone, Annarita; Bossi, Silvia; D’Amico, Silvia; Valle, Jaume del; Micera, Silvestro; Navarro, Xavier

doi:10.1088/1741-2552/aa6bac

Cited by 31 publications

(20 citation statements)

References 60 publications

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“…Some reports have characterized the FBR to intraneural implants in cats (30) or in humans (28) , but these studies were conducted after implantation of rigid multielectrode Utah slanted arrays and the stiffness of these electrodes has been reported to contribute to traumatic nerve injuries produced by mechanical tension and an increased FBR (40) . However, here we describe in detail the progression of the FBR to longitudinal intraneural devices fabricated with polyimide, a flexible material that can deform in 3D and adapt with the nerve (41) , widely used in the fabrication of nerve electrodes implanted in rats (18), (42), (43) and in humans (13)- (15) . Therefore, the information in this study may help to design novel strategies for modulating the FBR against electrodes placed within the peripheral nerve.…”

Section: Discussionmentioning

confidence: 99%

Time course study of long‐term biocompatibility and foreign body reaction to intraneural polyimide‐based implants

Oliva

Navarro

Valle

2017

J Biomedical Materials Res

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The foreign body reaction (FBR) against an implanted device is characterized by the formation of a fibrotic tissue around the implant. In the case of interfaces for peripheral nerves, used to stimulate specific group of axons and to record different nerve signals, the FBR induces a matrix deposition around the implant creating a physical separation between nerve fibers and the interface that may reduce its functionality over time. In order to understand how the FBR to intraneural interfaces evolves, polyimide non-functional devices were implanted in rat peripheral nerve. Functional tests (electrophysiological, pain and locomotion) and histological evaluation demonstrated that implanted devices did not cause any alteration in nerve function, in myelinated axons or in nerve architecture. The inflammatory response due to the surgical implantation decreased after 2 weeks. In contrast, inflammation was higher and more prolonged in the device implanted nerves with a peak after 2 weeks. With regard to tissue deposition, a tissue capsule appeared soon around the devices, acquiring maximal thickness at 2 weeks and being remodeled subsequently. Immunohistochemical analysis revealed two different cell types implicated in the FBR in the nerve: macrophages as the first cells in contact with the interface and fibroblasts that appear later at the edge of the capsule. Our results describe how the FBR against a polyimide implant in the peripheral nerve occurs and which are the main cellular players. Increasing knowledge of these responses will help to improve strategies to decrease the FBR against intraneural implants and to extend their usability. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 746-757, 2018.

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Section: Discussionmentioning

confidence: 99%

Time course study of long‐term biocompatibility and foreign body reaction to intraneural polyimide‐based implants

Oliva

Navarro

Valle

2017

J Biomedical Materials Res

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“…The effects have been assessed in terms of anatomical and histological measures of the capsule and the infiltrating cells. Finally, provided polyimide has been widely used as substrate of multiple peripheral nerve electrodes implanted both in animals (Delgado‐Martínez et al, ; del Valle and Navarro ) and in humans (Raspopovic et al, ; Oddo et al, ), the effects of dexamethasone have been also evaluated in the FBR to polyimide electrode implants, for comparing the differences between device substrates.…”

mentioning

confidence: 99%

Dexamethasone Reduces the Foreign Body Reaction to Intraneural Electrode Implants in the Peripheral Nerve of the Rat

Oliva

Navarro

Valle

2018

The Anatomical Record

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Intraneural electrodes must be in intimate contact with nerve fibers to have a proper function, but this interface is compromised due to the foreign body reaction (FBR). The FBR is characterized by a first inflammatory phase followed by a second anti-inflammatory and fibrotic phase, which results in the formation of a tissue capsule around the implant, causing physical separation between the active sites of the electrode and the nerve fibers. We have tested systemically several anti-inflammatory drugs such as dexamethasone (subcutaneous), ibuprofen and maraviroc (oral) to reduce macrophage activation, as well as clodronate liposomes (intraperitoneal) to reduce monocyte/macrophage infiltration, and sildenafil (oral) as an antifibrotic drug to reduce collagen deposition in an FBR model with longitudinal Parylene C intraneural implants in the rat sciatic nerve. Treatment with dexamethasone, ibuprofen, or clodronate significantly reduced the inflammatory reaction in the nerve in comparison to the saline group after 2 weeks of the implant, whereas sildenafil and maraviroc had no effect on infiltration of macrophages in the nerve. However, only dexamethasone was able to significantly reduce the matrix deposition around the implant. Similar positive results were obtained with dexamethasone in the case of polyimide-based intraneural implants, another polymer substrate for the electrode. These results indicate that inflammation triggers the FBR in peripheral nerves, and that anti-inflammatory treatment with dexamethasone may have beneficial effects on lengthening intraneural interface functionality.Advanced neuroprostheses are intended to link the human nervous system with electronic or robotic prostheses, with the aim of restoring motor and sensory functions lost after neural injuries or amputations. Various neuroprosthetic systems include an interface with the peripheral nerve.

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“…Moreover, the electrode-nerve interface showed limited inflammation in this acute experiment [123], proving the need for long-term studies. Of note is the double-aisle regenerative electrode which consists of a double-sided thin-film polyimide planar electrode, called the "septum", with 12 circular active sides on each side, longitudinally inserted inside a silicone tube, creating two electrically-insulated compartments to allow regeneration of separated nerve fascicles [124]. For experimentation, tibial and fibular nerves of the rat were chosen for each aisle.…”

Section: Regenerative Electrodesmentioning

confidence: 99%

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Yildiz

Shin

Kaufman

2020

J NeuroEngineering Rehabil

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The field of prosthetics has been evolving and advancing over the past decade, as patients with missing extremities are expecting to control their prostheses in as normal a way as possible. Scientists have attempted to satisfy this expectation by designing a connection between the nervous system of the patient and the prosthetic limb, creating the field of neuroprosthetics. In this paper, we broadly review the techniques used to bridge the patient's peripheral nervous system to a prosthetic limb. First, we describe the electrical methods including myoelectric systems, surgical innovations and the role of nerve electrodes. We then describe non-electrical methods used alone or in combination with electrical methods. Design concerns from an engineering point of view are explored, and novel improvements to obtain a more stable interface are described. Finally, a critique of the methods with respect to their long-term impacts is provided. In this review, nerve electrodes are found to be one of the most promising interfaces in the future for intuitive user control. Clinical trials with larger patient populations, and for longer periods of time for certain interfaces, will help to evaluate the clinical application of nerve electrodes.

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Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode

Abstract: This multi-aisle regenerative electrode may be suitable for neuroprosthetic applications, such as prostheses, for the restoration of hand function after amputation or severe nerve injuries.

Cited by 31 publications

References 60 publications

Time course study of long‐term biocompatibility and foreign body reaction to intraneural polyimide‐based implants

Time course study of long‐term biocompatibility and foreign body reaction to intraneural polyimide‐based implants

Dexamethasone Reduces the Foreign Body Reaction to Intraneural Electrode Implants in the Peripheral Nerve of the Rat

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

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