Fascicular elastin within tendon contributes to the magnitude and modulus gradient of the elastic stress response across tendon type and species

Eekhoff, Jeremy D.; Abraham, James; Schott, Hayden; Solon, Lorenzo F.; Ulloa, Gabriella E; Zellers, Jennifer A.; Cannon, Paul C.; Lake, Spencer P.

doi:10.1016/j.actbio.2022.03.025

Cited by 4 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is said that insufficient elastin changes the recruitment of collagen fibers, causing tissue elongation, and the straightness of collagen fibers leads to a delay in the ability of tissues to bear loads ( Grant et al, 2015 ; Fazaeli et al, 2020 ). After elastin degradation, the patellar tendon is in an extended state without a preload, similar to the phenomenon where the joint relaxes ( Eekhoff et al, 2023 ), and the natural tissue becomes more malleable, severely harming the human body. In this study, the low and high moduli after enzyme treatment were significantly reduced, which was similar to a study on bronchus ( Mariano et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…Clinical research has shown that elastic fibers are affected by hereditary diseases such as Marfan syndrome and skin laxity, causing joint relaxation which damages the mechanical integrity of the tendons and connective tissues near the joints ( Zhang et al, 2022 ; Krarup et al, 2023 ). Elastic fibers degenerate during aging, possibly causing a loss of anti-fatigue ability and increasing the risk of tendon injury in older adults ( Eekhoff et al, 2023 ). As a dense connective tissue, elastin in the patellar tendon can combine with molecules, such as decorin and dimers, affecting the mechanical properties of the tendon ( Beach et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…The elastin content and function of different species and types of tendons are different, and the elastin content of human tendons is the highest, compared with pigs, cows and mice ( Eekhoff et al, 2023 ). Before entering the experimental study of human tendon injury repair, it is generally verified on animal models.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Liu,

Deng,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Background: The treatment of patellar tendon injury has always been an unsolved problem, and mechanical characterization is very important for its repair and reconstruction. Elastin is a contributor to mechanics, but it is not clear how it affects the elasticity, viscoelastic properties, and structure of patellar tendon.Methods: The patellar tendons from six fresh adult experimental pigs were used in this study and they were made into 77 samples. The patellar tendon was specifically degraded by elastase, and the regional mechanical response and structural changes were investigated by: (1) Based on the previous study of elastase treatment conditions, the biochemical quantification of collagen, glycosaminoglycan and total protein was carried out; (2) The patellar tendon was divided into the proximal, central, and distal regions, and then the axial tensile test and stress relaxation test were performed before and after phosphate-buffered saline (PBS) or elastase treatment; (3) The dynamic constitutive model was established by the obtained mechanical data; (4) The structural relationship between elastin and collagen fibers was analyzed by two-photon microscopy and histology.Results: There was no statistical difference in mechanics between patellar tendon regions. Compared with those before elastase treatment, the low tensile modulus decreased by 75%–80%, the high tensile modulus decreased by 38%–47%, and the transition strain was prolonged after treatment. For viscoelastic behavior, the stress relaxation increased, the initial slope increased by 55%, the saturation slope increased by 44%, and the transition time increased by 25% after enzyme treatment. Elastin degradation made the collagen fibers of patellar tendon become disordered and looser, and the fiber wavelength increased significantly.Conclusion: The results of this study show that elastin plays an important role in the mechanical properties and fiber structure stability of patellar tendon, which supplements the structure-function relationship information of patellar tendon. The established constitutive model is of great significance to the prediction, repair and replacement of patellar tendon injury. In addition, human patellar tendon has a higher elastin content, so the results of this study can provide supporting information on the natural properties of tendon elastin degradation and guide the development of artificial patellar tendon biomaterials.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Liu,

Deng,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…In addition, there was no interface between cortical and trabecular bones. It was recently reported that the magnitude and modulus gradient of fascicular elastin in living tendon could contribute to the tensile mechanical response of the tendon, likely by regulating collagen engagement under load 47 . This means that a detailed representation of the material properties of the bone (anisotropy, the architecture of the cancellous bone, a discontinuous interface between the two bones) should be accounted for.…”

Section: Discussionmentioning

confidence: 99%

Thread shape, cortical bone thickness, and magnitude and distribution of stress caused by the loading of orthodontic miniscrews: finite element analysis

Sakamaki

Watanabe

Iwasa

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Cortical bone thickness is assumed to be a major factor regulating miniscrew stability. We investigated stress distribution in two miniscrews with different thread shapes (type A and B) and in cortical bone of three different thicknesses using three-dimensional (3D) finite element (FE) models. More specifically, 3D FE models of two different miniscrews were created and placed obliquely or vertically into a cylindrical bone model representing different cortical bone thicknesses. When force was applied to the miniscrew, the stress distribution on the screw surface and in the peri-implant bone was assessed using FE methodology. Miniscrew safety was evaluated using a modified Soderberg safety factor. Screw head displacement increased with a decrease in cortical bone thickness, irrespective of screw type. The smallest minimum principal stresses on the screw surfaces remained constant in type A miniscrews on changes in cortical bone thickness. Minimum principal stresses also appeared on the cortical bone surface. Lower absolute values of minimum principal stresses were seen in type A miniscrews when placed vertically and with upward traction in obliquely placed type B miniscrews. Both miniscrews had acceptable safety factor values. Taken together, orthodontists should select and use the suitable miniscrew for each patient in consideration of bone properties.

show abstract

Special Issue: Mechanics of Cells and Fibers

2023

View full text Add to dashboard Cite

Fascicular elastin within tendon contributes to the magnitude and modulus gradient of the elastic stress response across tendon type and species

Cited by 4 publications

References 45 publications

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Thread shape, cortical bone thickness, and magnitude and distribution of stress caused by the loading of orthodontic miniscrews: finite element analysis

Special Issue: Mechanics of Cells and Fibers

Contact Info

Product

Resources

About