Fasciclin IV: Sequence, expression, and function during growth cone guidance in the grasshopper embryo

Kolodkin, Alex L.; Matthes, David; O’Connor, Timothy P.; Patel, Nipam H.; Admon, Arie; Bentley, David; Goodman, Corey S.

doi:10.1016/0896-6273(92)90237-8

Cited by 337 publications

(210 citation statements)

References 46 publications

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“…Class 3 Semas have been investigated as repulsive axon guidance molecules (Kolodkin et al, 1992;Luo et al, 1993;Kruger et al, 2005). In this regard, Sema3A has been most well studied.…”

Section: Introductionmentioning

confidence: 99%

Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons

Callander

Lamont

Childs

et al. 2007

Developmental Dynamics

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Retinal ganglion cells (RGCs) extend axons that exit the eye, cross the midline at the optic chiasm, and synapse on target cells in the optic tectum. Class three semaphorins (Sema3s) are a family of molecules known to direct axon growth. We undertook an expression screen to identify sema3s expressed in the retina and/or brain close to in-growing RGC axons, which might therefore influence retinal-tectal pathfinding. We find that sema3Aa, 3Fa, 3Ga, and 3Gb are expressed in the retina, although only sema3Fa is present during the time window when the axons extend. Also, we show that sema3Aa and sema3E are present near or at the optic chiasm. Furthermore, sema3C, 3Fa, 3Ga, and 3Gb are expressed in regions of the diencephalon near the path taken by RGC axons. Finally, the optic tectum expresses sema3Aa, 3Fa, 3Fb, and 3Gb. Thus, sema3s are spatiotemporally placed to influence RGC axon growth. Developmental Dynamics 236:2918 -2924, 2007.

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“…Class 3 Semas have been investigated as repulsive axon guidance molecules (Kolodkin et al, 1992;Luo et al, 1993;Kruger et al, 2005). In this regard, Sema3A has been most well studied.…”

Section: Introductionmentioning

confidence: 99%

Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons

Callander

Lamont

Childs

et al. 2007

Developmental Dynamics

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“…There is only limited evidence concerning specific physiologic roles for transmembrane semaphorins. Antibody blockade of G-Sema I, a grasshopper transmembrane semaphorin, interferes with Ti1 neuron axonal pathfinding in the limb bud (19). Genetic analysis of its Drosophila homologue, D-Sema I, suggests that it may also function as a repulsive signal for selected motor and central nervous system axons (20).…”

mentioning

confidence: 99%

A PDZ Protein Regulates the Distribution of the Transmembrane Semaphorin, M-SemF

Wang¹,

Kalb

Strittmatter

1999

Journal of Biological Chemistry

115

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M-SemF is a membrane-associated, neurally enriched member of the semaphorin family of axon guidance signals. We considered whether the cytoplasmic domain of M-SemF might possess a signaling function and/or might control the distribution of M-SemF on the cell surface. We identify a PDZ-containing neural protein as an MSemF cytoplasmic domain-associated protein (SEM-CAP-1). SEMCAP-2 is a closely related nonneuronal protein. SEMCAP-1 has recently also been identified as GIPC, by virtue of its interaction with the RGS protein GAIP in vitro (De

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“…Semaphorins are a family of secreted and membraneassociated proteins studied extensively for their role in nervous system development, especially in axon guidance (Kolodkin et al 1992(Kolodkin et al , 1993Luo et al 1993;Puschel et al 1995). Semaphorins have also been implicated in the function of the immune system (Shi et al 2000;Takegahara et al 2005) and a variety of diseases, including cancer (Woodhouse et al 2003;Neufeld et al 2005;Basile et al 2006), retinal degeneration (Rice et al 2004;Abid et al 2006), schizophrenia (Eastwood et al 2003), and rheumatoid arthritis (Miller et al 2004).…”

mentioning

confidence: 99%

The Early Developmental Gene Semaphorin 5c Contributes to Olfactory Behavior in Adult Drosophila

et al. 2007

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Behaviors are complex traits influenced by multiple pleiotropic genes. Understanding the mechanisms that give rise to complex behaviors requires an understanding of how variation in transcriptional regulation shapes nervous system development and how variation in brain structure influences an organism's ability to respond to its environment. To begin to address this problem, we used olfactory behavior in Drosophila melanogaster as a model and showed that a hypomorphic transposon-mediated mutation of the early developmental gene Semaphorin-5c (Sema-5c) results in aberrant behavioral responses to the repellant odorant benzaldehyde. We fine mapped this effect to the Sema-5c locus using deficiency mapping, phenotypic reversion through P-element excision, and transgenic rescue. Morphometric analysis of this Sema5c allele reveals subtle neuroanatomical changes in the brain with a reduction in the size of the ellipsoid body. High-density oligonucleotide expression microarrays identified 50 probe sets with altered transcriptional regulation in the Sema-5c background and quantitative complementation tests identified epistatic interactions between nine of these coregulated genes and the transposon-disrupted Sema-5c gene. Our results demonstrate how hypomorphic mutation of an early developmental gene results in genomewide transcriptional consequences and alterations in brain structure accompanied by profound impairment of adult behavior.

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Fasciclin IV: Sequence, expression, and function during growth cone guidance in the grasshopper embryo

Cited by 337 publications

References 46 publications

Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons

Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons

A PDZ Protein Regulates the Distribution of the Transmembrane Semaphorin, M-SemF

The Early Developmental Gene Semaphorin 5c Contributes to Olfactory Behavior in Adult Drosophila

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