Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp

Roll, Deborah M.; Ireland, Chris M.; Lu, Helen S. M.; Clardy, Jon

doi:10.1021/jo00249a025

Cited by 173 publications

(117 citation statements)

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“…It was originally isolated as a compound showing antimicrobial activity from the sponge Fascaplysinopsis sp. (Roll et al 1988). It is a commercially available compound, broadly used for the research purposes; however, it has never been entered into clinical trials.…”

Section: Selective Inhibitorsmentioning

confidence: 99%

The CDK inhibitors in cancer research and therapy

Cicenas

Valius²

2011

J Cancer Res Clin Oncol

220

176

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Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells. Cyclin-dependent kinases (CDK) play an essential role in the control of the cell cycle and/or proliferation. These kinases as well as their regulators are frequently deregulated in diVerent human tumors. Aberrations in CDK activity have also been observed in viral infections, Alzheimer's, Parkinson's diseases, ischemia and some proliferative disorders. This led to an intensive search for small-molecule CDK inhibitors not only for research purposes, but also for therapeutic applications. Here, we discuss seventeen CDK inhibitors and their use in cancer research or therapy. This review should help researchers to decide which inhibitor is best suited for the speciWc purpose of their research. For this purpose, the targets, commercial availability and IC 50 values are provided for each inhibitor. The review will also provide an overview of the clinical studies performed with some of these inhibitors.

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Section: Selective Inhibitorsmentioning

confidence: 99%

The CDK inhibitors in cancer research and therapy

Cicenas

Valius²

2011

J Cancer Res Clin Oncol

220

176

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“…154 This sample also contained the known metabolite fascaplysin 200, which had been reported in 1988 from a Fijian collection of Fascaplysinopsis reticulata. 155 Both 140 and 141 inhibit phospholipase A 2 and antimicrobial activity was reported for 140 and 200.…”

Section: Fascaplysinopsis Spmentioning

confidence: 97%

Investigations of the Marine Flora and Fauna of the Islands of Palau

Faulkner¹,

Newman²,

Cragg³

2004

ChemInform

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“…Fascaplysin is a pigment, first isolated from marine sponge Fascaplysinopsis Bergquist sp in 1988 and identified as an anti-microbial agent [39]. It was later found to exert anti-proliferative activity against HeLa (ovarian cancer) cell line though apoptosis.…”

Section: Fascaplysinmentioning

confidence: 99%