Fas-Mediated Inflammatory Response in<i>Listeria monocytogenes</i>Infection

Uchiyama, Ryosuke; Yonehara, Shin; Tsutsui, Hiroko

doi:10.4049/jimmunol.1203059

Cited by 27 publications

(39 citation statements)

References 58 publications

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“…Interestingly, recent studies have found that caspase-8 is involved in modulating IL-1b maturation (42)(43)(44)(45)(46)(47). Caspase-8 is also involved in priming inflammasome for activation during Salmonella infection (31).…”

Section: Discussionmentioning

confidence: 99%

Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes

Chen

Xing

et al. 2015

The Journal of Immunology

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Cryptococcus neoformans is an opportunistic fungal pathogen that causes cryptococccosis in immunocompromised patients as well as immunocompetent individuals. Host cell surface receptors that recognize C. neoformans have been widely studied. However, intracellular sensing of this pathogen is still poorly understood. Our previous studies have demonstrated that both biofilm and acapsular mutant of C. neoformans are able to activate the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome. In the current study, it was found that opsonization-mediated internalization of encapsulated C. neoformans also activated the canonical NLRP3–apoptosis-associated speck-like protein containing a CARD (ASC)–caspase-1 inflammasome. In addition, the internalized C. neoformans activated the noncanonical NLRP3–ASC–caspase-8 inflammasome as well, which resulted in robust IL-1β secretion and cell death from caspase-1–deficient primary dendritic cells. Interestingly, we found that caspase-1 was inhibitory for the activation of caspase-8 in dendritic cells upon C. neorformans challenge. Further mechanistic studies showed that both phagolysosome membrane permeabilization and potassium efflux were responsible for C. neoformans–induced activation of either the canonical NLRP3–ASC–caspase-1 inflammasome or the noncanonical NLRP3–ASC–caspase-8 inflammasome. Moreover, challenge with zymosan also led to the activation of the noncanonical NLRP3–ASC–caspase-8 inflammasome in cells absent for caspase-1. Collectively, these findings uncover a number of novel signaling pathways for the innate immune response of host cells to C. neoformans infection and suggest that manipulating NLRP3 signaling may help to control fungal challenge.

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Section: Discussionmentioning

confidence: 99%

Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes

Chen

Xing

et al. 2015

The Journal of Immunology

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“…However, RIPK3 has been shown to be partially involved in this TRIF–caspase 8-dependent pathway 108 . Engagement of FAS ligand (FASL; also known as TNFSF6 and CD95) by FAS is another pathway by which caspase 8 is activated to cleave IL-1β and IL-18 independently of caspase 1 (Refs 109, 110 ). In this context, TLR-induced FAS expression drives caspase 8- and FADD-mediated release of IL-1β and IL-18 (Ref 109 ).…”

Section: Caspase 8 and Inflammationmentioning

confidence: 99%

Converging roles of caspases in inflammasome activation, cell death and innate immunity

2015

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Inflammatory and apoptotic caspases are central players in inflammation and apoptosis, respectively. However, recent studies have revealed that these caspases have functions beyond their established roles. In addition to mediating cleavage of the inflammasome-associated cytokines interleukin-1β (IL-1β) and IL-18, inflammatory caspases modulate distinct forms of programmed cell death and coordinate cell-autonomous immunity and other fundamental cellular processes. Certain apoptotic caspases assemble structurally diverse and dynamic complexes to direct inflammasome and interferon (IFN) responses to fine tune inflammation. In this Review, we discuss the expanding and interconnected roles of caspases that highlight new aspects of this family of cysteine proteases in innate immunity.

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“…However, the FasL-induced release of IL-18 and IL-1β does not require caspase-1, NLRP3, or NLRC4 [42,43]. Very recently, caspase-8, but not caspase-1, caspase-9, or caspase-11, was demonstrated to be critical for Fas-mediated IL-18 maturation [44,45]. As mentioned above, IL-18 can induce FasL expression by NK cells [37].…”

Section: Endotoxin-induced Liver Injurymentioning

confidence: 99%

Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice

Tsutsui

Nishiguchi

2014

IJMS

Self Cite

122

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Kupffer cells reside within the liver sinusoid and serve as gatekeepers. They produce pro- and anti-inflammatory cytokines and other biologically important molecules upon the engagement of pattern recognition receptors such as Toll-like receptors. Kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of Kupffer cells. In this paper, we review the importance of Kupffer cells in murine acute liver injuries and focus on the following two models: lipopolysaccharide (LPS)-induced liver injury, which is induced by priming with Propionibacterium acnes and subsequent challenge with LPS, and hypercoagulability-mediated acute liver failure such as that in concanavalin A (Con A)-induced hepatitis. Kupffer cells are required for LPS sensitization induced by P. acnes and are a major cellular source of interleukin-18, which induces acute liver injury following LPS challenge. Kupffer cells contribute to Con A-induced acute liver failure by initiating pathogenic, intrasinusoidal thrombosis in collaboration with sinusoidal endothelial cells. The mechanisms underlying these models may shed light on human liver injuries induced by various etiologies such as viral infection and/or abnormal metabolism.

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Fas-Mediated Inflammatory Response inListeria monocytogenesInfection

Cited by 27 publications

References 58 publications

Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes

Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes

Converging roles of caspases in inflammasome activation, cell death and innate immunity

Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice

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