Fas ligand expression and mediated activation of an apoptosis program in bovine follicular granulosa cells

Yang, Runjun; Xu, Shaohang; Zhao, Zhihui; Li, Junya

doi:10.1016/j.gene.2011.11.032

Cited by 5 publications

(2 citation statements)

References 26 publications

(24 reference statements)

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“…Fas/FasL can also induce apoptosis in vitro [ 26 ]. Studies have also shown that Fas/FasL can significantly inhibit the proliferation of bovine follicular GCs [ 28 ]. It can be seen that Bim and Fas/FasL are both apoptosis-related factors.…”

Section: Discussionmentioning

confidence: 99%

Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology

Tao

2022

Bioengineered

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Based on the research methods of network pharmacology, this study analyzed the improvement effect of berberine (BBR) on premature ovarian failure (POF) and its molecular mechanism. Carry out GO and KEGG enrichment analysis by R language to obtain the potential targets and pathways of BBR in the improvement of POF. Use SD rats and ovarian granulosa cells (GCs) for experimental verification. ELISA was used to measure the content of related hormones in the serum, CCK-8 was used to measure cell viability, western blot was used to measure the content of the target protein in the ovaries and GCs, and q-RT-PCR was used to detect the expression of the target genes in the ovaries and GCs. Predicted by network pharmacology: PTEN, AKT1, FoxO1, FasL, and Bim are the targets with the highest relative correlation between BBR and POF. The results of experiments show that the treatment of low and medium doses of BBR can increase the ovarian index of rats; BBR can increase the levels of Estradiol (E 2 ) and Anti-Mullerian hormone (AMH) in the serum of rats and reduce the levels of Follicle stimulating hormone (FSH) and Luteinizing hormone (LH). BBR can increase the cell viability of GCs; BBR can inhibit the PTEN/AKT1/FoxO1 signaling pathway and its phosphorylation level and reduce the expression of Fas/FasL and Bim mRNA. Overall, BBR can promote the ovarian to maintain normal hormone levels, protect GCs, and enhance the function of POF.

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Section: Discussionmentioning

confidence: 99%

Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology

Tao

2022

Bioengineered

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“…High mRNA and protein levels of Fas and FasL in GCs of the antral follicles have been positively correlated with the degree of follicular atresia (Inoue et al, 2006). Overexpression of FasL was reported to suppress proliferation and promote apoptosis of GCs both in vitro and in vivo (Yang et al, 2012), while GCs were induced to proliferation when downregulating Fas/FasL (Wu et al, 2021). The signaling of TRAIL, a death ligand, its role of inducing apoptosis of GCs could be blocked by decoy receptor 1 in follicles (Inoue et al, 2003; Wada, Manabe, Inoue, et al, 2002).…”

Section: Mechanisms Underlying Apoptosis Of Gcsmentioning

confidence: 99%

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

Zhong

Luo

Zhou

et al. 2022

J of Applied Toxicology

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Abnormal ovarian function is the main manifestation of female reproductive toxicity. Granulosa cells (GCs) play an important role in determining the fate of follicles and are the main effector cells of the female reproductive system. Excessive apoptosis of GCs leads to pathological folliculogenesis and further reproductive damage. However, drugs available for treatment of female reproductive toxicity are limited. Recent studies have confirmed that various natural products and bioactive ingredients of traditional Chinese medicine (TCM) can inhibit apoptosis of GCs and protect ovarian function. In this review, the mechanisms underlying the proapoptotic and antiapoptotic effects of natural products and bioactive ingredients of TCM on the proliferation, function, and apoptosis of GCs are summarized based on the findings of reports published over the past 10 years as reference for the treatment of female reproductive toxicity.

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Replication of Akabane virus and related orthobunyaviruses in a fetal-bovine-brain-derived cell line

Suda,

Murota,

Shirafuji

et al. 2024

Arch Virol

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Fas ligand expression and mediated activation of an apoptosis program in bovine follicular granulosa cells

Cited by 5 publications

References 26 publications

Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology

Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

Replication of Akabane virus and related orthobunyaviruses in a fetal-bovine-brain-derived cell line

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