Fas-antisense long noncoding RNA is differentially expressed during maturation of human erythrocytes and confers resistance to Fas-mediated cell death

Villamizar, Olga; Chambers, Christopher B.; Mo, Yin‐Yuan; Torry, Donald S.; Hofstrand, Reese; Riberdy, Janice M.; Persons, Derek A.; Wilber, Andrew

doi:10.1016/j.bcmd.2016.03.002

Cited by 18 publications

(17 citation statements)

References 60 publications

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“…Alterations in protein expression of TNF family members such as TNFR-1, Fas, DR4, and DR5 may lead to resistance to anticancer drugs. It has been noted that soluble Fas could block apoptosis induced by Fas [34, 35]. A clinical trial has verified that mutation of DR4 and DR5 contributes to drug resistance in glioma [36].…”

Section: Mechanisms Of Cancer Cell Drug Resistancementioning

confidence: 99%

Long non-coding RNAs in anti-cancer drug resistance

et al. 2016

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Chemotherapy is one of the basic treatments for cancers; however, drug resistance is mainly responsible for the failure of clinical treatment. The mechanism of drug resistance is complicated because of interaction among various factors including drug efflux, DNA damage repair, apoptosis and targets mutation. Long non-coding RNAs (lncRNAs) have been a focus of research in the field of bioscience, and the latest studies have revealed that lncRNAs play essential roles in drug resistance in breast cancer, gastric cancer and lung cancer, et al. Dysregulation of multiple targets and pathways by lncRNAs results in the occurrence of chemoresistance. In this review, we will discuss the mechanisms underlying lncRNA-mediated resistance to chemotherapy and the therapeutic potential of lncRNAs in future cancer treatment.

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Section: Mechanisms Of Cancer Cell Drug Resistancementioning

confidence: 99%

Long non-coding RNAs in anti-cancer drug resistance

et al. 2016

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“…Although thousands of erythroid stage-specific lncRNAs have been identified 20 – 24 , only a few have been functionally analyzed. For example, long intergenic non-coding RNA (lincRNA) EPS 25 and lncRNA Fas-antisense 1 26 promote erythroid progenitor survival; lnc-EC1 and lnc-EC6 regulate erythroblast enucleation; 22 , 27 and lncRNA-αGT confers maximal activation of α-globin gene expression in chickens 28 . Nevertheless, the biological functions of the vast majority of lncRNAs have not been described.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development

Liu

Tong

et al. 2018

Nat Commun

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In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell development and function. While lncRNAs modulate diverse physiological and pathological cellular processes, their involvement in heme-dependent mechanisms is largely unexplored. In this study, we elucidated a lncRNA (UCA1)-mediated mechanism that regulates heme metabolism in human erythroid cells. We discovered that UCA1 expression is dynamically regulated during human erythroid maturation, with a maximal expression in proerythroblasts. UCA1 depletion predominantly impairs heme biosynthesis and arrests erythroid differentiation at the proerythroblast stage. Mechanistic analysis revealed that UCA1 physically interacts with the RNA-binding protein PTBP1, and UCA1 functions as an RNA scaffold to recruit PTBP1 to ALAS2 mRNA, which stabilizes ALAS2 mRNA. These results define a lncRNA-mediated posttranscriptional mechanism that provides a new dimension into how the fundamental heme biosynthetic process is regulated as a determinant of erythrocyte development.

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“…Fas-antisense 1 ( Fas-AS1 , also known as Saf ), an lncRNA antisense to Fas cell surface death receptor coding gene, was upregulated during the differentiation stage of erythropoiesis by the erythroid transcription factors GATA binding protein 1 (GATA1) and Kruppel-like factor 1 (KLF1), and negatively regulated by the nuclear factor kappa B (NF-κB). In erythroblasts derived from CD34 + hematopoietic stem cells, the overexpression of Fas-AS1 reduced the Fas surface levels and protected cells from death signals [ 25 ].…”

Section: Long Non-coding Rnas: Expression Patterns In Tissues or Cmentioning

confidence: 99%

Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis

Salviano-Silva

Lobo‐Alves

Almeida

et al. 2018

ncRNA

102

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A significant proportion of mammalian genomes corresponds to genes that transcribe long non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning the roles played by lncRNAs in different biological processes has increased considerably. This intense interest in lncRNAs has produced a major shift in our understanding of gene and genome regulation and structure. It became apparent that lncRNAs regulate gene expression through several mechanisms. These RNAs function as transcriptional or post-transcriptional regulators through binding to histone-modifying complexes, to DNA, to transcription factors and other DNA binding proteins, to RNA polymerase II, to mRNA, or through the modulation of microRNA or enzyme function. Often, the lncRNA transcription itself rather than the lncRNA product appears to be regulatory. In this review, we highlight studies identifying lncRNAs in the homeostasis of various cell and tissue types or demonstrating their effects in the expression of protein-coding or other non-coding RNA genes.

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Fas-antisense long noncoding RNA is differentially expressed during maturation of human erythrocytes and confers resistance to Fas-mediated cell death

Cited by 18 publications

References 60 publications

Long non-coding RNAs in anti-cancer drug resistance

Long non-coding RNAs in anti-cancer drug resistance

Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development

Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis

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