Fas-Activated Apoptosis and Apoptosis Mediators in Human Trabecular Meshwork Cells

Helicobacter pylori IgG Antibodies in Aqueous Humor and Serum of Subjects With Primary Open Angle and Pseudo-exfoliation Glaucoma in a South Indian Population

“…[23][24][25][26] Human trabecular meshwork cells can be stimulated to undergo apoptosis via the Fas/FasL pathway. 27 Vacuolating cytotoxin (VacA) has been reported to form anion selective, low conductance, voltage dependent channels in planar membranes. The formation of lowconductance VacA pores in the cell membrane results in a change in ion permeability.…”

Apoptosis and reduced influenza A virus specific CD8+ T cells in aging mice

“…32,39,43,47,50,74,76 Cross-linking of TFN-a with TNFRI or Fas with FasL will result in increased apoptosis and may cause exaggerated depletion of Figure 9 Effects of IL-12 on apoptosis, IFN-g production and CD8…”

“…The Baylor Animal Protocol and Research Committee approved use of animals according to principles expressed in the National Institutes of Health, USPHS, Guide for the Care and Use of Laboratory Animals. The old and young mice were primed with a sublethal dose (0.05 LD 50 ) of influenza A/Taiwan/1/86 (H1N1) virus using small particle aerosolization as previously described. 17,94 Generation and assay of in¯uenza virus-speci®c CTL responses…”

Adenoviral p53 gene transfer inhibits human Tenon's capsule fibroblast proliferation

“…For p53 mediated G1 arrest, p21 WAF-1/Cip1 appears to be essential. [14][15][16][17][18] In normal cells this 21 kDa product of the WAF1 gene is found in a complex of cyclins, cyclin dependent kinases (CDK), and the proliferating cell nuclear antigen (PCNA), where it appears to inhibit CDK activity. 14-17 Among the effects of p21 WAF-1/Cip1 mediated CDK inhibition is the prevention of the CDK dependent inactivation of the product of the retinoblastoma gene.…”

“…13 For p53 mediated G1 arrest p21 WAF-1/Cip1 appears to be essential. [14][15][16][17][18] In a rabbit 9 and recently in a primate 19 model p21 WAF-1/Cip1 gene transfer has been shown to effectively prevent filtration surgery from failure. Adenovirus is a double strain DNA virus that has been proved to be a sufficient vector for gene transfer to many ocular cells.…”