“…6,7 We have previously demonstrated that this radiosensitizing effect of FTIs on wild-type Rasexpressing cells was due to the induction of radiation-induced mitotic cell death, strongly suggesting that a farnesylated protein might be involved in controlling these mechanisms. 6,7 In terms of identifying this farnesylated protein, the small GTPase ras homolog gene family, member B (RhoB) appears to be potentially a very interesting candidate. RhoB is a member of the Rho family of GTPases that regulate cytoskeletal actin, focal adhesion formation, proliferation, cell adhesion signaling, receptor-mediated internalization, motility, transformation, invasion, and transcription.…”