Farnesol‐mediated inhibition of <i>Candida albicans</i> yeast growth and rescue by a diacylglycerol analogue

Uppuluri, Priya; Mekala, Satish; Chaffin, W. LaJean

doi:10.1002/yea.1501

Cited by 46 publications

(50 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This repression was also observed in C. dubliniensis and C. parapsilosis (Jabra-Rizk et al, 2006;Rossignol et al, 2007). Interestingly, a cell cycle mechanism was only monitored for C. albicans (Uppuluri et al, 2007). The present study demonstrated that the effect of E ,E -farnesol is also influenced by the temperature and nutrient conditions (Table 4, Figure 4).…”

Section: Discussionsupporting

confidence: 68%

“…Their growth was significantly influenced by its addition. Several publications have reported in vitro growth inhibition by E ,E -farnesol (Davis-Hanna et al, 2008;Shirtliff et al, 2009;Uppuluri et al, 2007). This repression was also observed in C. dubliniensis and C. parapsilosis (Jabra-Rizk et al, 2006;Rossignol et al, 2007).…”

Section: Discussionmentioning

confidence: 74%

“…E,E-farnesol affects growth and metabolic activity Uppuluri et al (2007) recently showed that E ,Efarnesol affects the growth of C. albicans SC 5314. In our study we were able to reproduce these data (not shown).…”

Section: Ee-farnesol Modulates Biofilm Formationmentioning

confidence: 99%

“…E ,E -farnesol affects the shape of C. albicans and has been shown to alter its gene expression, e.g. metabolic and hypha-specific genes (Cao et al, 2005;DavisHanna et al, 2008;Enjalbert et al, 2005;Uppuluri et al, 2007). Recent publications pointed out that E ,E -farnesol regulates the morphogenesis through multifactorial actions.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The quorum‐sensing molecule E,E‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species

Weber

Schulz

Ruhnke

2010

Yeast

View full text Add to dashboard Cite

Diseases caused by Candida species are an increasing problem. Candida species are associated with high overall mortality, due to a variety of virulence factors such as the yeast-to-hyphal switch and proteolytic enzymes. The phenomenon of microbial communication known as quorum sensing also seems to play an important role. The main characteristics of the quorum-sensing molecule E ,E -farnesol are well known for C. albicans. The present study focused on two questions. One of them concerned the secretion of E ,E -farnesol by C. albicans and involved a close examination of the effect of the medium (serum) and the origin of the isolates used. The second one dealt with the activity of E ,E -farnesol in non-C. albicans species, such as C. tropicalis and C. parapsilosis, e.g. its impact on biofilm formation and growth. Under serum conditions, C. albicans produced up to 58% more E ,E -farnesol at 37• C than at 30• C. The growth of all isolates was reduced and delayed by the administration of E ,Efarnesol. Of all Candida species, C. tropicalis isolates were most strongly affected by the addition of E ,E -farnesol. Biofilm formation on polystyrene was affected by E ,Efarnesol treatment in all non-C. albicans species and C. albicans. E ,E -farnesol exerts its main effect by altering the metabolic activity and growth inhibition of treated Candida species. The results obtained indicate that the presence of E ,E -farnesol in the environment not only regulates the morphology of the Candida species but also affects its fitness. In this regard, the secretion of E ,E -farnesol might provide an advantage for members of the microbial community.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 74%

Section: Ee-farnesol Modulates Biofilm Formationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The quorum‐sensing molecule E,E‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species

Weber

Schulz

Ruhnke

2010

Yeast

View full text Add to dashboard Cite

show abstract

“…albicans e A. nidulans (Voziyan et al, 1995;Yang e Kazanietz, 2003;Taylor et al, 2005;Fairn et al, 2007;Uppuluri et al, 2007;Savoldi et al, 2008;Román et al, 2009). A expressão constitutiva de Pkc1 leva a resistência de S. cerevisiae frente à presença de farnesol, possivelmente pela atividade na regulação da produção de espécies reativas de oxigênio (EROs) na cadeia de transporte de elétrons da mitocôndria (Fairn et al, 2007).…”

Section: -Peptídeo Sinal E Via Secretóriaunclassified

Caracterização funcional do gene codificador de uma proteína com peptídeo sinal, masA, de Aspergillus fumigatus

Cocio¹

View full text Add to dashboard Cite

El gen MAS1/GAS2, conocido como "Magnaporthe Apressoria Specific", se identificó como altamente expresado durante la formación de la appressorium fito patógena hongo filamentoso Magnaporthe grisea. En Aspergillus fumigatus, hongo saprofito oportunista, se identificó masA gen ortólogo de MAS1/GAS2 como upregulated en un análisis de transcriptómica expuesto a voriconazol y anidulafungina, antifúngicos que afectan la síntesis de ergosterol y la pared celular, respectivamente. En ambos ortólogos tener una estructura en el extremo N-terminal de la proteína llamada región del péptido señal. Durante la caracterización fenotípica y funcional de gen masA de A. fumigatus se determinó en un análisis in silico de la presencia de péptido señal en la región N-terminal de la proteína. En la caracterización fenotípica de una cepa de A. fumigatus masA -deletado ningún cambio estructural de conidióforos y su aspecto macromorfológico no fue identificado. La cepa deletado masA caracterización es resistente a voriconazol y farnesol que inhiben la síntesis de ergosterol y una molécula de detección de quórum, respectivamente. Al evaluar el nivel de expresión génica masA contra diferentes clases de drogas foi observado el gen súper se expresa cuando se produce daño en la pared celular y la membrana del ADN, la síntesis de lípidos y ácidos grasos, y el estrés oxidativo. En la presencia de daños en la pared celular fúngica causada por anidulafungina, proteína MasA se encuentra cerca de en la pared celular la punta de la hifa y, además, era capaz de transferir al medio extracelular de la proteína fusionada a ella, GFP. Por lo tanto, posiblemente, MasA participa en la vía secretora del hongo sobre todo en momentos de estrés como la ruptura de la pared celular. La capacidad de secreción natural de los hongos filamentosos se ha explotado en el contexto industrial durante décadas. Indicando para este fin, una posible aplicabilidad para este péptido señal.

show abstract

Farnesol and Candida albicans: Quorum Sensing or Not Quorum Sensing?

Krom

Levy

Meijler

et al. 2015

Israel Journal of Chemistry

View full text Add to dashboard Cite

Quorum sensing (QS) molecules function within communities of single‐cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans.

show abstract

Farnesol‐mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue

Cited by 46 publications

References 58 publications

The quorum‐sensing molecule E,E‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species

The quorum‐sensing molecule E,E‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species

Caracterização funcional do gene codificador de uma proteína com peptídeo sinal, masA, de Aspergillus fumigatus

Farnesol and Candida albicans: Quorum Sensing or Not Quorum Sensing?

Contact Info

Product

Resources

About