Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis

Hao, Haiping; Cao, Lijuan; Jiang, Changtao; Che, Yuan; Zhang, Songyang; Takahashi, Shogo; Wang, Guangji; Gonzalez, Frank J.

doi:10.1016/j.cmet.2017.03.007

Cited by 295 publications

(313 citation statements)

References 45 publications

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“…Inflammasome such as Nod‐like receptor pyrin domain‐containing protein 3 (NLRP3) is a cytoplasmic multiportion complex of the innate immune system (Hao et al, ) that leads to maturation and production of cytokines such as IL‐18, IL‐1β, and pyroptosis (lytic host cell death; Liu, Jing, et al, ; Luo et al, ).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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“…98 Intriguingly, a recent study reported that cholestasis aggravates sepsis, and bile acids not only potentiate NLRP3 and IL-1b expression but also stimulate NLRP3 inflammasome activation by driving a prolonged Ca 2+ influx. 3 It is noteworthy that this positive influence of bile acids is detected in a wide spectrum of macrophages but not in monocytes.…”

Section: Other Inflammatory Lipid Mediators and Inflammasome Activationmentioning

confidence: 98%

“…Recently, bile acids have been shown to play an active role in NLRP3 inflammasome activity by promoting the transcription of IL‐1 β and calcium mobilization in macrophages. For LPS‐induced sepsis, exogenous bile acid addition results in a notable shorter survival time for LPS‐treated mice, while pretreatment with cholestyramine resin, a sequestrant of bile acid, significantly decreased the serum level of IL‐1 β and reduced mortality . An earlier study reported that EP treatment blocked NF‐ κ B signalling in macrophages and decreased high‐mobility group box 1 (HMGB1) in circulation in septic mice .…”

Section: Metabolic Regulation Of Inflammasome Activation In Inflammatmentioning

confidence: 99%

Metabolic regulation of inflammasomes in inflammation

Yang

Liu

et al. 2019

Immunology

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Summary Inflammasome activation and subsequent inflammatory cytokine secretion are essential for innate immune defence against multiple stimuli and are regarded as a link to adaptive immune responses. Dysfunction of inflammasome activation has been discovered at the onset or progression of infectious diseases, autoimmune diseases and cancer, all of which are also associated with metabolic factors. Furthermore, many studies concerning the metabolic regulation of inflammasome activation have emerged in recent years, especially regarding the activity of the NLRP3 inflammasome under metabolic reprogramming. In this review, we discuss the molecular mechanisms of the interactions between metabolic pathways and inflammasome activation, which exerts further important effects on various diseases.

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“…This paper also suggests that extracellular ATP can prime the NLRP3 inflammasome through deubiquitination. A recent paper described that NLRP3 inflammasome regulates cholestasis-associated sepsis via sensing of bile acid and ATP 34. NLRC4 can discriminate between commensal bacteria and pathogens to suppress their colonization and to coordinate intestinal epithelial cell expulsion with lipid mediator and cytokine secretion 35–37.…”

Section: Inflammasome Signaling Pathwaymentioning

confidence: 99%

Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment

Thi

Hong

2017

J Cancer Prev

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Chronic inflammation is a critical modulator of carcinogenesis through secretion of inflammatory cytokines, which leads to the formation of an inflammatory microenvironment. In this process, the inflammasome plays an important role in the expression and activation of interleukin (IL)-1β and IL-18 to promote cancer development. The inflammasome is a multiprotein complex consisting of several nucleotide-binding domain and leucine-rich repeat containing receptor, adaptor proteins, and caspase 1 (CASP1). It senses the various intracellular (damage-associated molecular patterns) and extracellular (pathogen-associated molecular patterns) stimuli. A primed inflammasome recruits adaptor proteins, activates CASP1 to enhance the proteolytic cleavage of pro-IL-1β and IL-18, and sends the signal to respond to each insult. Depending on stimuli and cell contexts, several inflammasomes are closely associated with the initiation and promotion of carcinogenesis. In contrast, inflammasomes also show an ambivalent effect on carcinogenesis by enhancing inflammatory cell death (pyroptosis) and repairing damaged tissues. Although the inflammasome plays a controversial role in carcinogenesis, it may be a promising target for human cancer prevention and treatment. A more in-depth study on the role of the inflammasome in carcinogenesis, based on stimuli, cell contexts, and cancer stages, can lead to the development of novel therapeutic strategies against malignant human cancers.

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Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis

Cited by 295 publications

References 45 publications

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Metabolic regulation of inflammasomes in inflammation

Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment

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