Farming and malignant lymphoma in Hancock County, Ohio.

Dubrow, Robert; Paulson, John; Indian, Robert W.

doi:10.1136/oem.45.1.25

Cited by 15 publications

(9 citation statements)

References 20 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Farmers on intensive chicken farms 54 43 97 33 (9) 32 (9) 32 (9) 8 (6) 6 (6) 7 (6) Workers at chicken slaughterhouses 33 17 50 40 (10) 41 (11) 40 (10) 12 (9) 9 (4) 11 (8) Group exposed to quails: Workers on quail farms including quail slaughter 25 40 65 33 (7) 37* (12) 35 (11) 7 (6) 9 (5) 9 (5) *P < 0 04 men v women. Farmers on dairy or pig farms with poultry (n = 33)% 6-1 33-3 24-2 27-3 6-1 3 0 Group highly exposed to chickens:…”

Section: Serological Testsmentioning

confidence: 99%

Occupational exposure to poultry and prevalence of antibodies against Marek's disease virus and avian leukosis retroviruses.

et al. 1996

View full text Add to dashboard Cite

Objectives-To compare the prevalence of antibodies against Marek's disease herpes virus (MDV) and against avian leukosis viruses type C (ALV) in groups of workers exposed to poultry and in unexposed groups. Methods-Antibodies directed against avian viral proteins were detected by enzyme linked immunosorbent assay in 549 subjects. Exposure to chickens was high in two subgroups: farmers on intensive chicken farms and workers at chicken slaughterhouses. One subgroup, traditional farmers on dairy or pig farms with poultry, had moderate exposure to poultry. Another subgroup, farmers and slaughterhouse workers on quail farms, had high exposure to quails. Three subgroups were not exposed to chickens: farmers on dairy or pig farms without poultry, workers at cattle slaughterhouses, and white collar workers. Also, MDV antibodies were tested after serum sample adsorption with chicken antigens in 134 serum samples. Results-The prevalence of antibodies against MDV was significantly higher in the exposed subgroups than in unexposed groups (odds ratio (OR) 6'17; 95% confidence interval (95% CI) 3-91-9.75). No association was found between seroprevalence and age. However, higher prevalence was found among women and was related to duration of exposure to chickens. The concentration of antibodies from a few subjects remained very high after adsorption. Significant differences between the men and women were found for the prevalence of antibodies for ALV but were not related to exposure to chickens.Conclusions-The prevalence of antibodies against MDV was significantly higher among workers exposed to chickens and was related to sex and duration of exposure. The higher prevalence of antibodies against avian oncogenic viruses found among women compared with men may be induced by differences in exposure or by genetic factors. The meaning of these high titres could be related to the presence of MDV in humans. Because the involvement of animal oncogenic viruses in human cancer is indicated by epidemiological and some experimental studies, the integration of viral DNA in human cells needs to be investigated. (Occup Environ Med 1996;53:403-410)

show abstract

Section: Serological Testsmentioning

confidence: 99%

Occupational exposure to poultry and prevalence of antibodies against Marek's disease virus and avian leukosis retroviruses.

et al. 1996

View full text Add to dashboard Cite

show abstract

“…1 Other studies have also reported farmers to be at increased risk for NHL, chronic lymphoid leukaemia (CLL), Hodgkin's disease, and multiple myeloma. [2][3][4][5][6][7] Veterinarians are undoubtedly occupationally exposed to zoonotic infectious agents and several studies of cancer in veterinarians have been conducted. Figgs and colleagues 8 reported a significant increased risk of multiple myeloma and Blair et al found elevated proportions of LH cancer deaths among veterinarians.…”

mentioning

confidence: 99%

Risk of lymphatic or haematopoietic cancer mortality with occupational exposure to animals or the public

et al. 2005

View full text Add to dashboard Cite

Background: Occupational exposure to animals or the public could result in exposure to infectious agents, which may play a role in the aetiology of lymphohaematopoietic (LH) cancers. Aims: To conduct a population based, case-control study of death certificate data from 1984 to 1998 in 24 US states in order to evaluate the risk of mortality from LH neoplasms associated with occupational exposure to animals or the public. Methods: Cases were selected as those with an underlying cause of death of non-Hodgkin's lymphoma (NHL, n = 72 589), Hodgkin's disease (HD, n = 5479), multiple myeloma (n = 35 857), or leukaemia (n = 68 598); 912 615 controls were randomly selected from all remaining deaths, frequency matched on age, sex, race, and geographic region. Results: Occupational exposure to animals was associated with modest increased risks of mortality from all four LH cancers; these associations varied by region. Occupational exposure to the public was associated with only negligible increased risk with LH cancer outcomes. Occupations involving animal exposure were predominantly agricultural, and the risks associated with employment in the livestock industry exceeded the corresponding risks associated with the crop industry for all outcomes except HD. Conclusions: Increased risks of NHL, HD, multiple myeloma, and leukaemia were associated with occupations that involved animal exposure. Regional differences in risk imply that the risks may be associated with exposure to specific livestock or farming practices. However, these associations may be confounded by other farming related exposures, such as pesticides. Because the use of death certificates to classify occupation may result in misclassification during aetiologically relevant time periods, these hypotheses should be further explored in studies with detailed information on lifetime occupation.

show abstract

“…Sixteen of the studies included in the analyses were restricted to white males (10,11,13,15,27,28,30,(34)(35)(36)(37)(38)(39)(40)(41)(42). Five studies reported results only for men (4,12,(43)(44)(45).…”

Section: Resultsmentioning

confidence: 99%

“…Elevated risks have been reported for exposure to fabric dust (3), creosote (4), organic solvents (4,5), chlorophenols (5), and phenoxy acids (4,5). Elevated risks have been reported for wood-related occupations (6), fishermen (7), meat processors (8), and farmers (9)(10)(11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 99%