Maize production in Swaziland's middleveld is being increasingly threatened by the Striga asiatica weed (also called witchweed). It parasitises the maize crop to provide itself with water and nutrients, preventing the crop from growing properly. In this paper we examine the impacts of this bio-indicator of land degradation on rural livelihoods, investigating how farmers and policy makers are responding to the problem. Our results show that farmers' ability to control weed infestations is determined by a number of environmental, social and political-economic drivers and that national policies to reduce land degradation offer little assistance. Low-technology methods employed by farmers are an important step in alleviating the problem, but farmers' understandings of why these methods work are limited and they often neglect to combine control strategies. At the local level, there is a need to support farmer-to-farmer learning and education programmes to broaden and deepen farmer knowledge about S. asiatica. At the national level a more supportive policy context is necessary that recognises weeds as an indicator of a more serious overall land degradation problem, and which uses broader criteria to determine what constitutes land degradation. Without this attention, the threat from S. asiatica could increase in both area and intensity, with profound effects on both food security and the sustainability of rural livelihoods.