Farm waste-eggshell nanoparticles constitute gel for safe navigation of probiotic across the stomach

Sahu, Bandana Kumari; Sharma, Sandeep; Kaur, Kamaljit; Chandel, Mahima; Sood, Parul; Singh, Manpreet; Shanmugam, Vijayakumar

doi:10.1016/j.mtcomm.2022.104876

Cited by 4 publications

(3 citation statements)

References 73 publications

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“…The gel did not present a reduction in viability even after 120 min, while for free cells a reduction of 50% was observed. These results reinforce the ability of ESNP-based gels to improve probiotic delivery by shielding the bacteria from the acidic pH of the gastric fluid and their potential use in the management of intestinal diseases [157].…”

Section: Nanoparticle-based Drug Delivery Systemssupporting

confidence: 71%

Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview

Lopes,

Roque-Borda,

Duarte

et al. 2023

Pharmaceutics

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Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, most known as ulcerative colitis (UC) and Crohn’s disease (CD), that affects the gastrointestinal tract (GIT), causing considerable symptoms to millions of people around the world. Conventional therapeutic strategies have limitations and side effects, prompting the exploration of innovative approaches. Probiotics, known for their potential to restore gut homeostasis, have emerged as promising candidates for IBD management. Probiotics have been shown to minimize disease symptoms, particularly in patients affected by UC, opening important opportunities to better treat this disease. However, they exhibit limitations in terms of stability and targeted delivery. As several studies demonstrate, the encapsulation of the probiotics, as well as the synthetic drug, into micro- and nanoparticles of organic materials offers great potential to solve this problem. They resist the harsh conditions of the upper GIT portions and, thus, protect the probiotic and drug inside, allowing for the delivery of adequate amounts directly into the colon. An overview of UC and CD, the benefits of the use of probiotics, and the potential of micro- and nanoencapsulation technologies to improve IBD treatment are presented. This review sheds light on the remarkable potential of nano- and microparticles loaded with probiotics as a novel and efficient strategy for managing IBD. Nonetheless, further investigations and clinical trials are warranted to validate their long-term safety and efficacy, paving the way for a new era in IBD therapeutics.

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Section: Nanoparticle-based Drug Delivery Systemssupporting

confidence: 71%

Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview

Lopes,

Roque-Borda,

Duarte

et al. 2023

Pharmaceutics

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“…Natural or bio-based hydrogels are obtained from natural polymers, such as polysaccharides (alginate, chitosan, dextran, etc. ), synthetic hydrogels from synthetic monomers (ethylene glycol, vinyl alcohol, acrylic acid, and acrylamide), and the semi-synthetic hydrogels are, of course, the result of the combination of natural and synthetic materials [ 2 , 13 , 14 , 15 ]. Alginates undergo enzymatic or radiolytic degradation to produce oligosaccharide that influences plant physiological activities.…”

Section: Introductionmentioning

confidence: 99%

NaAlg-g-AA Hydrogels: Candidates in Sustainable Agriculture Applications

Mănăilă

Demeter

Călina

et al. 2023

Gels

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Nowadays, the degradation of agricultural soil due to various factors should be a major concern for everyone. In this study, a new sodium alginate-g-acrylic acid-based hydrogel was developed simultaneously by cross-linking and grafting with accelerated electrons to be used as soil remediation. The effect of irradiation dose and NaAlg contents on the gel fraction, network and structural parameters, sol–gel analysis, swelling power, and swelling kinetics of NaAlg-g-AA hydrogels have been investigated. It was demonstrated that NaAlg hydrogels show significative swelling power that is greatly dependent on their composition and irradiation dose; they keep the structure and are not degraded in different pH conditions and different water sources. Diffusion data revealed a non-Fickian transport mechanism (0.61–0.99) also specific to cross-linked hydrogels. The prepared hydrogels were proved as excellent candidates in sustainable agriculture applications.

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“…The nanotechnology application enables farmers to kill weeds, pests, and diseases without hurting the plants. [38][39][40] Also, nano-research is imperative in preventing the negative effects of crop cultivation and animal farming via genetic engineering, which inadvertently increases the strength of crops and the production of farm animals. [41][42][43] Agricultural technology, including nanotools, enable stakeholders such as farmers, scientists, and policymakers to sustain agriculture through plant nutrients, nanocopper, and nano-nitrogen fertilizer production.…”

Section: Nanotechnologymentioning

confidence: 99%

Can agriculture technology improve food security in low- and middle-income nations? a systematic review

Brenya

Zhu

Sampene

2023

Sustainable Food Technol.

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Farm waste-eggshell nanoparticles constitute gel for safe navigation of probiotic across the stomach

Cited by 4 publications

References 73 publications

Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview

Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview

NaAlg-g-AA Hydrogels: Candidates in Sustainable Agriculture Applications

Can agriculture technology improve food security in low- and middle-income nations? a systematic review

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