Farklı Tipteki Köpek Meme Karsinomlarında PCNA ve MMP-9 Ekspresyonlarının İmmunohistokimyasal Olarak Değerlendirilmesi

Abstract

The aim of this study was to evaluate reveal whether there is a significant relationship between cell proliferation and invasion-metastasis capacity in various mammary carcinomas subtypes observed in dogs immunohistochemically with PCNA and MMP-9 markers. The material of this study consisted of tissue samples of mammary carcinomas taken from 6 Kangal and 4 Setter dogs with an average age of 8.4 years brought to our department between 2012 and 2020. 4 of 10 mammary carcinoma cases were classified as intraductal papillary carcinoma, 4 as carcinoma mixed, 1 as solid carcinoma and 1 as tubular carcinoma. We found the highest mean number of PCNA and MMP-9 positive cells in solid subtype. In conclusion, there may be a positive relationship between cell proliferation, invasion and metastasis capacity under the solid subtype.