FarGen: Bioresource From the Faroe Genome Project

Gregersen, Noomi; Apol, Katrin Didriksen; Weihe, Pál; Steig, Bjarni á; Andorsdóttir, Guðrið

doi:10.5334/ojb.71

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…The FarGen cohort comprise 1541 individuals. The recruitment procedures, socio-demographics, availability of the bioresources, DNA extraction, DNA barcoding using the 10x Genomics-Chromium controller, library construction, and sequencing has been described previously [12,15,16]. In short, inclusion criteria were: 1) participants had to be 18 years or older, 2) had to live in the Faroe Islands or be of Faroese descent, and 3) had to join the project voluntarily.…”

Section: Subjects and Methods The Fargen Cohortmentioning

confidence: 99%

“…Data is available for research up on participants' re-consent. Researchers will be granted access to de-identified genetic-data and meta-data provided that the project protocol has been approved by the Faroese Scientific Ethical Committee and a template material/data transfer agreement has been signed with the Genetic Biobank of the Faroe Islands in compliance with GDPR (see reference [15]).…”

Section: Data Availabilitymentioning

confidence: 99%

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FarGen: Elucidating the distribution of coding variants in the isolated population of the Faroe Islands

Mortensen

Thomsen²,

Lydersen³

et al. 2022

Eur J Hum Genet

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Here we present results from FarGen Phase I exomes. This dataset is based on the FarGen cohort, which consists of 1,541 individuals from the isolated population of the Faroe Islands. The purpose of this cohort is to serve as a reference catalog of coding variants, and to conduct population genetic studies to better understand the genetic contribution to various diseases in the Faroese population. The first whole-exome data set comprise 465 individuals and a total of 148,267 genetic variants were discovered. Principle Component Analysis indicates that the population is isolated and weakly structured. The distribution of variants in various functional classes was compared with populations in the gnomAD dataset; the results indicated that the proportions were consistent across the cohorts, but probably due to a small sample size, the FarGen dataset contained relatively few rare variants. We identified 19 variants that are classified as pathogenic or likely pathogenic in ClinVar; several of these variants are associated with monogenetic diseases with increased prevalence in the Faroe Islands. The results support previous studies, which indicate that the Faroe Islands is an isolated and weakly structured population. Future studies may elucidate the significance of the 19 pathogenic variants that were identified. The FarGen Phase I dataset is an important step for genetic research in the Faroese population, and the next phase of FarGen will increase the sample size and broaden the scope.

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Section: Subjects and Methods The Fargen Cohortmentioning

confidence: 99%

Section: Data Availabilitymentioning

confidence: 99%

FarGen: Elucidating the distribution of coding variants in the isolated population of the Faroe Islands

Mortensen

Thomsen²,

Lydersen³

et al. 2022

Eur J Hum Genet

Self Cite

View full text Add to dashboard Cite

show abstract

“…Data collected for the FarGen-infrastructure is available for research up on participants' re-consent. researchers will be granted access to de-identified genetic-data and meta-data provided that the project protocol has been approved by the Faroese Scientific ethical Committee and a template material/data transfer agreement has been signed with the Genetic Biobank of the Faroe Islands in compliance with GDPr [16].…”

Section: Data Availabilitymentioning

confidence: 99%

“…With the FarGen infrastructure, we are collecting biological material for whole-genome sequencing to build a reference panel of genetic variants within this population [ 16 ]. Coupled with registry data such as extended genealogical records, which go back to 1650 for 85% of the population, with some lineages going back to the 1100s ( http://biobank.fo/en ), this population may be ideal for population-based genetic research to reveal unprecedented details about human genetic disease and as a stepping stone towards precision medicine [ 17 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

FarGen – participants in the genetic research infrastructure of the Faroe Islands

Apol

Lydersen

Mortensen

et al. 2021

Scand J Public Health

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Background: The demographic history of the Faroe Islands makes this isolated population – founded in the 9th century – interesting for genetic research. The goal of the FarGen project was to recruit individuals to the FarGen infrastructure to promote research into the genetic features of the Faroese people, and to develop a reference panel of population-specific variants. We aimed to recruit 1500 individuals. Participation was voluntary; participants had to donate a blood sample for whole-genome sequencing, and had to answer a questionnaire regarding sociodemographics, health, motivation and attitude towards participation in genetic research. Methods: A total of 1541 participants voluntarily joined the project, donated a blood sample and returned the questionnaire. Results: Answers from the questionnaire show that participants are, in general, European, have children, have a relatively high level of education, rate their health to be good, are willing to participate in future health-related research, and were motivated to sign up primarily to participate in research to help others and local research competency building. Conclusions: Overall, the initial cohort of the FarGen infrastructure comprises 3% of the Faroese population, and represents the general population well based on the collected sociodemographic data. However, there is an excess of women, and some geographic sub-regions and age groups are slightly underrepresented. We find the recruitment method with voluntary sign-up appropriate, and knowledge acquired through the first phase will aid the next phase of the project, with the aim of expanding the FarGen cohort with additional individuals, bio-specimens and body measurements in order to perform multifactorial analyses.

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Robust arm and leg muscle adaptation to training despite ACE inhibition: a randomized placebo-controlled trial

et al. 2022

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FarGen: Bioresource From the Faroe Genome Project

Cited by 3 publications

References 6 publications

FarGen: Elucidating the distribution of coding variants in the isolated population of the Faroe Islands

FarGen: Elucidating the distribution of coding variants in the isolated population of the Faroe Islands

FarGen – participants in the genetic research infrastructure of the Faroe Islands

Robust arm and leg muscle adaptation to training despite ACE inhibition: a randomized placebo-controlled trial

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