Far East Scarlet-Like Fever Caused by a Few Related Genotypes of<i>Yersinia pseudotuberculosis</i>, Russia

Тимченко, Н. Ф.; Adgamov, Ruslan R.; Popov, Alexander F.; Псарева, Е. К.; Sobyanin, K. A.; Gintsburg, A. L.; Sа, Ermolaeva

doi:10.3201/eid2203.150552

Cited by 22 publications

(12 citation statements)

References 12 publications

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“…Yersinia strains are typically resistant to beta-lactam antibiotics due to beta-lactamase genes located in the chromosome (20). (25,26). Based on the virulence in the mouse model, Y. enterocolitica can be divided into three groups consisting of highly pathogenic, weakly pathogenic and non-pathogenic strains (10).…”

Section: Characteristics Of Yersinia Sppmentioning

confidence: 99%

Identification of Yersinia at the Species and Subspecies Levels Is Challenging

Fredriksson-Ahomaa

Joutsen

Laukkanen‐Ninios

2018

Curr Clin Micro Rpt

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The genus Yersinia currently includes species, of which Y. enterocolitica and Y. pseudotuberculosis are enteropathogenic. The identification of Y. enterocolitica in particular is very demanding, because it consists of a group of very heterogeneous bacteria, including pathogenic and non-pathogenic strains. The aim of the review is to provide recent information on the characteristics and identification of Yersinia spp. and sources of enteropathogenic Yersinia spp. Identification of Yersinia spp. is still mainly based on biochemical tests and serotyping, but molecular methods have increasingly also been used. Sequencing the whole genome enables more accurate identification of enteropathogenic Yersinia spp. Pathogenic Y. enterocolitica strains of different bioserotypes have newly been identified from various animal sources. Moreover, the virulence gene ail has been detected in non-pathogenic Yersinia strains, especially from wild animals. Correct identification of pathogenic Yersinia strains is essential in assessing the health risk for humans and animals.

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Section: Characteristics Of Yersinia Sppmentioning

confidence: 99%

Identification of Yersinia at the Species and Subspecies Levels Is Challenging

Fredriksson-Ahomaa

Joutsen

Laukkanen‐Ninios

2018

Curr Clin Micro Rpt

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“…For the infection, strains of the four plasmid types of Y. pseudotuberculosis were obtained from the collection of Somov Research Institute of Epidemiology and Microbiology: 1) H-5015 T + strain (82 + : 48 + ) containing two plasmids pVM 82 and pYV, LD 50 was 3.7 × 10 7 , the infecting dose 4 × 10 8 ; 2) H-5015 Tstrain (82 + : 48 -) containing single pVM 82 plasmid, the infecting dose 4x10 8 ; 3) H-5013 T + strain (48 + ) containing single pYV plasmid, LD 50 was 1.4x10 8 , the infecting dose 2x10 9 ; 4) H-5013 Tplasmid-free strain (48 -), the infecting dose 2x10 9 . The infecting dose of strains causing a systemic infection was equal to 10-fold LD 50 [16].…”

Section: Bacteriamentioning

confidence: 99%

“…The virulence of the Yersinia genus bacteria is associated with the presence of the pYV plasmid with a molecular mass of 42-48 Mda. This plasmid codes up to 20 species of toxic Yersinia outer membrane proteins (Yop-s), their ability to type III bacterial secretion (T3SS) [7] and the stability of these bacteria to phagocytosis [8][9][10]. The particular interest is the little studied Y. pseudotuberculosis extrachromosomal replicon, a plasmid with a molecular weight of 82 MDa (pVM 82 plasmid), which is found only in Y. pseudotuberculosis strains serovar I -the most common etiologic agent of epidemic pseudotuberculosis (Far Eastern scarlet-like fever, FESLF) in humans.…”

Section: Introductionmentioning

confidence: 99%

The Metabolic Activity of Innate Immunity Cells in Experimental Infection Caused by Various Plasmid Types of Yersinia Pseudotuberculosis

Сомова¹

2018

BMB

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In a comparative aspect, the functional state of inflammation effector cells in animals infected with various plasmid types of Yersinia pseudotuberculosis was studied. The metabolic activity of peritoneal exudate cells has been investigated in an experimental infection caused by four plasmid types of Y. pseudotuberculosis: type 82 + : 48 + , containing two plasmids pVM 82 and pYV; type 82 + : 48containing single pVM 82 plasmid; type 48 + : 82containing single pYV plasmid; plasmid-free type 48-: 82-. The parameters of enzyme activity (ATP-ase, 5'-nucleotidase, lactate dehydrogenase, myeloperoxidase) and the level of nitric oxide metabolites were determined. The variability of the metabolic activity of the cells in the inflammatory focus (peritoneal exudate containing neutrophils and macrophages) in infected animals has been established. In response to infection with Y. pseudotuberculosis strain containing two plasmids pYV and pVM82, the production of the nitric oxide metabolites, rather than the active forms of oxygen, had the primary importance in providing the bactericidal potential of phagocytes, compared to animals infected with a strain containing a single pVM82 plasmid. It was concluded that a special biological effect associated with the pVM 82 plasmid available in the Far Eastern strains of the causative agent of epidemic pseudotuberculosis (Far Eastern scarlet-like fever) was involved in the provision of predominantly nitroxide-dependent bactericidal mechanisms of innate immunity cells in this infection.

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“…Somov were awarded the USSR State Prize. Later, with the introduction of molecular genetic research methods, it was proved that FESLF is associated with a concrete clonal line of Y. pseudotuberculosis , widespread in the Russian Federation and characterized by a specific plasmid profile (pVM82, pYV 48 MDa), sequence type (2ST) and yadA gene allele (1st allele) [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia

Сомова¹,

Antonenko

Тимченко³

et al. 2020

Pathogens

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Pseudotuberculosis in humans until the 1950s was found in different countries of the world as a rare sporadic disease that occurred in the form of acute appendicitis and mesenteric lymphadenitis. In Russia and Japan, the Yersinia pseudotuberculosis (Y. pseudotuberculosis) infection often causes outbreaks of the disease with serious systemic inflammatory symptoms, and this variant of the disease has been known since 1959 as Far Eastern Scarlet-like Fever (FESLF). Russian researchers have proven that the FESLF pathogen is associated with a concrete clonal line of Y. pseudotuberculosis, characterized by a specific plasmid profile (pVM82, pYV 48 MDa), sequence (2ST) and yadA gene allele (1st allele). This review summarized the most important achievements in the study of FESLF since its discovery in the Far East. It has been established that the FESLF causative agent is characterized by a unique phenomenon of psychrophilicity, which consists of its ability to reproduce in the environment with its biologically low and variable temperature (4–12 °C), at which the pathogen multiplies and accumulates while maintaining or increasing its virulence, which ensures the emergence and development of the epidemic process. The key genetic and biochemical mechanisms of Y. pseudotuberculosis adaptation to changing environmental conditions were characterized, and the morphological manifestations of the adaptive variability of these bacteria in different conditions of their habitat were revealed. The main features of the pathogenesis and morphogenesis of FESLF, including those associated with the Y. pseudotuberculosis toxigenicity, were presented. The pathogenetic value of the plasmid PVM82, found only in the FESLF pathogen, was shown.

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Far East Scarlet-Like Fever Caused by a Few Related Genotypes ofYersinia pseudotuberculosis, Russia

Cited by 22 publications

References 12 publications

Identification of Yersinia at the Species and Subspecies Levels Is Challenging

Identification of Yersinia at the Species and Subspecies Levels Is Challenging

The Metabolic Activity of Innate Immunity Cells in Experimental Infection Caused by Various Plasmid Types of Yersinia Pseudotuberculosis

Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia

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