“…Interestingly, replication stress in FANCJ null patient fibroblasts, as well as in FANCJ knockdown cells, indicated that DSBs occurred under replication stress at diverse endogenous microsatellite loci (repeats of CTG (DMPK, ATXN1, ERDA1, TCF4), ATTCT (ATXN10), Pu/Py (PKD1), G quadruplex consensus (TUBA1B, HBB, MYC), and poly-T (BRIP1/FANCJ, TP53, TP63)) (Fig. 4) [92]. Equivalent treatment of cells knocked down for other proteins in the Fanconi anemia pathway, or fibroblasts from patients carrying mutations in other Fanconi anemia proteins (FANCA, -C, -D1, -D2, -I, -M, -Q, -P) did not show this effect.…”