Fan-shaped body neurons are involved in <i>period</i>-dependent regulation of long-term courtship memory in <i>Drosophila</i>

Sakai, Tomoaki; Inami, Show; Sato, Seisho; Kitamoto, Toshihiro

doi:10.1101/lm.028092.112

Cited by 17 publications

(21 citation statements)

References 23 publications

(39 reference statements)

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“…Previous investigations have demonstrated that period mutants are compromised in LTM in courtship conditioning and aversive long-term odor conditioning [19][20][21]. We therefore first had to test the mutant flies for LTM in our appetitive olfactory paradigm.…”

Section: Circadian Clock Mutants Fail To Demonstrate Time-odor Associmentioning

confidence: 99%

Flies Remember the Time of Day

et al. 2015

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The circadian clock enables organisms to anticipate daily environmental cycles and drives corresponding changes in behavior [1, 2]. Such endogenous oscillators also enable animals to display time-specific memory [1, 3-5]. For instance, mice and honeybees associate the location of a stimulus (like food or mate) with a certain time of day (time-place learning) [6, 7]. However, the mechanism underlying time-related learning and memory is not known. In the present study, we investigate time-specific odor learning. We use a genetically tractable animal, the fly Drosophila melanogaster. Starved flies are trained in the morning and afternoon to associate distinct odors with sucrose reward. The training is repeated the next day, and their time-dependent odor preference is tested on the third day. Our results indicate that Drosophila can express appetitive memory at the relevant time of day if the two conditioning events are separated by more than 4 hr. Flies can form time-odor associations in constant darkness (DD) as well as in a daily light-dark (LD) cycle, but not when kept under constant light (LL) conditions. Circadian clock mutants, period(01) (per(01)) and clock(AR) (clk(AR)), learned to associate sucrose reward with a certain odor but were unable to form time-odor associations. Our findings show that flies can utilize temporal information as an additional cue in appetitive learning. Time-odor learning in flies depends on a per- and clk-dependent endogenous mechanism that is independent of environmental light cues.

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Section: Circadian Clock Mutants Fail To Demonstrate Time-odor Associmentioning

confidence: 99%

Flies Remember the Time of Day

et al. 2015

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“…223 Short-term (immediate) and long-term (after 24 hours) courtship conditioning memory can be determined by measuring courtship levels of naïve males compared to males trained with a premated female, who are unreceptive. 227 To date, few studies have assessed age-related changes in response to courtship conditioning, and the results are contradictory. 224 Similar to other olfactory-based memory tasks, courtship memory has been shown to depend on the mushroom body region of the brain, where cVA perception is modulated by DA signaling in response to past experience.…”

Section: Courtship Conditioningmentioning

confidence: 99%

“…[224][225][226] However, courtship memory also depends on the circadian rhythm related gene period that is expressed in a cAMP-responsive transcription factor, CREB, dependent fashion by fan-shaped body neurons. 227 To date, few studies have assessed age-related changes in response to courtship conditioning, and the results are contradictory.…”

Section: Courtship Conditioningmentioning

confidence: 99%

Social behavior and aging: A fly model

Brenman-Suttner

Yost

Frame

et al. 2019

Genes Brain and Behavior

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The field of behavioral genetics has recently begun to explore the effect of age on social behaviors. Such studies are particularly important, as certain neuropsychiatric disorders with abnormal social interactions, like autism and schizophrenia, have been linked to older parents. Appropriate social interaction can also have a positive impact on longevity, and is associated with successful aging in humans. Currently, there are few genetic models for understanding the effect of aging on social behavior and its potential transgenerational inheritance. The fly is emerging as a powerful model for identifying the basic molecular mechanisms underlying neurological and neuropsychiatric disorders. In this review, we discuss these recent advancements, with a focus on how studies in Drosophila melanogaster have provided insight into the effect of aging on aspects of social behavior, including across generations.

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“…Since cry b mutants, which possess a non-functional peripheral oscillator in the antenna, maintain STM rhythmicity in DD, the authors suggest that the circadian STM modulation is due to the central oscillator, which might govern the availability of molecules involved in the memory-based signal transduction cascade ( 181 ). The circadian clock gene d per has also been implicated in Drosophila LTM, in both the olfactory learning and courtship conditioning paradigms ( 88 , 182 , 183 ). The role of d per in olfactory and courtship LTMs appeared to be independent from the circadian clock, since other clock mutants, such as tim 0 , Clk-Jrk , and cyc 0 , showed normal LTM ( 88 , 182 ).…”

Section: Circadian Clock Sleep Learning and Memory And Social Intementioning

confidence: 99%

“…Although the protocol differences in the two LM paradigms complicate the direct comparison of the results, it is interesting to note that d per is required outside the MBs in both cases. In particular, the per -dependent control of olfactory LTM maps at the level of the DAL neurons in the dorsal lateral protocerebrum ( 88 ), while for the courtship LTM the presence of d per is required at the level of the FB of the central complex ( 88 , 183 ). The activity of these neuronal structures seems to be mainly important for the LTM recall, rather than LTM formation and storage ( 88 , 183 ).…”

Section: Circadian Clock Sleep Learning and Memory And Social Intementioning

confidence: 99%

Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?

Zordan

Sandrelli

2015

Front. Neurol.

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There is evidence of a link between the circadian system and psychiatric diseases. Studies in humans and mammals suggest that environmental and/or genetic disruption of the circadian system leads to an increased liability to psychiatric disease. Disruption of clock genes and/or the clock network might be related to the etiology of these pathologies; also, some genes, known for their circadian clock functions, might be associated to mental illnesses through clock-independent pleiotropy. Here, we examine the features which we believe make Drosophila melanogaster a model apt to study the role of the circadian clock in psychiatric disease. Despite differences in the organization of the clock system, the molecular architecture of the Drosophila and mammalian circadian oscillators are comparable and many components are evolutionarily related. In addition, Drosophila has a rather complex nervous system, which shares much at the cell and neurobiological level with humans, i.e., a tripartite brain, the main neurotransmitter systems, and behavioral traits: circadian behavior, learning and memory, motivation, addiction, social behavior. There is evidence that the Drosophila brain shares some homologies with the vertebrate cerebellum, basal ganglia, and hypothalamus-pituitary-adrenal axis, the dysfunctions of which have been tied to mental illness. We discuss Drosophila in comparison to mammals with reference to the: organization of the brain and neurotransmitter systems; architecture of the circadian clock; clock-controlled behaviors. We sum up current knowledge on behavioral endophenotypes, which are amenable to modeling in flies, such as defects involving sleep, cognition, or social interactions, and discuss the relationship of the circadian system to these traits. Finally, we consider if Drosophila could be a valuable asset to understand the relationship between circadian clock malfunction and psychiatric disease.

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Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila

Cited by 17 publications

References 23 publications

Flies Remember the Time of Day

Flies Remember the Time of Day

Social behavior and aging: A fly model

Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?

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