Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory

Vandrey, Brianna; Garden, Derek L. F.; Ambrozova, Veronika; McClure, Christina; Nolan, Matthew F.; Ainge, James A.

doi:10.1016/j.cub.2019.11.027

Cited by 66 publications

(93 citation statements)

References 60 publications

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“…Further, the precise representations of previous object locations in distal CA1 suggest a role of LEC-hippocampus circuitry in object-place memory. Our findings are consistent with a role of projections from LEC to the hippocampus in episodic memory (Vandrey et al, 2020) and with reports that LEC manifests early pathology in Alzheimer's disease (Gómez-Isla et al, 1996;Khan et al, 2014;Kobro-Flatmoen, Nagelhus, & Witter, 2016;Stranahan & Mattson, 2010) . In contrast, MEC is part of a network that supports path integration, navigation, and spatial memory (Hales et al, 2014;Steffenach, Witter, Moser, & Moser, 2005;Tennant et al, 2018;Van Cauter et al, 2013) .…”

Section: Discussionsupporting

confidence: 92%

“…Our observations raise further questions regarding how object-related responses in CA1 relate to the memory and navigation functions performed within the EC-hippocampal network. LEC is required to integrate different features of an episode (Chao, Huston, Li, Wang, & de Souza Silva, 2016;Kuruvilla & Ainge, 2017;Rodo et al, 2017;Van Cauter et al, 2013;Vandrey et al, 2020;Wilson, Langston, et al, 2013;Wilson, Watanabe, Milner, & Ainge, 2013) , and our data further suggests that the multi-modal representations generated in LEC support place field representations in distal CA1 that precisely encode items within an environment and are sensitive to changes in their position. Further, the precise representations of previous object locations in distal CA1 suggest a role of LEC-hippocampus circuitry in object-place memory.…”

Section: Discussionsupporting

confidence: 65%

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Object and object-memory representations across the proximodistal axis of CA1

Vandrey

Ainge

2020

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AcknowledgementsThis work was supported by a Henry Dryerre scholarship from the Royal Society of Edinburgh to B.V. Abstract (154/300 words)Episodic memory requires information about objects to be integrated into a spatial framework. Place cells in the hippocampus encode spatial representations of objects that could be generated through signalling from the entorhinal cortex. Projections from lateral and medial entorhinal cortex to the hippocampus terminate in distal and proximal CA1, respectively. We recorded place cells in distal and proximal CA1 as rats explored an environment that contained objects. Place cells in distal CA1 demonstrated higher measures of spatial tuning and expressed place fields closer to objects. Further, remapping to object displacement was modulated by place field proximity to objects in distal, but not proximal CA1. Finally, representations of 1 previous object locations were more precise in distal CA1. Our data suggest that lateral entorhinal cortex inputs to the hippocampus support spatial representations that are more precise and responsive to objects in cue-rich environments. This is consistent with functional segregation in the entorhinal-hippocampal circuits underlying object-place memory.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 65%

Object and object-memory representations across the proximodistal axis of CA1

Vandrey

Ainge

2020

Preprint

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“…This hypothesis is underscored by the fact that the entorhinal cortex receives highly integrated information from other neocortical areas. Further strong support to the functional extension that we propose comes from the observation that reelin-positive fan cells in the lateral entorhinal (LEC) cortex are critical to episodic-like memories (Vandrey et al, 2020). Fan cells form a network that is comparable to that of stellate cells in the medial entorhinal cortex (Nilssen et al, 2018) and their electrophysiological properties, as wells as their propensity to intrinsic oscillations are very similar to stellate cells (Canto et al, 2011).…”

Section: Rodent Grid Cells: Is Their Spatial Activity Just a Facette supporting

confidence: 62%

Episodic memories: how do the hippocampus and the entorhinal ring attractors cooperate to create them?

Kovács

2020

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The brain is capable of registering a constellation of events, encountered only once, as an episodic memory that can last for a lifetime. As evidenced by the clinical case of the patient HM, memories preserving their episodic nature still depend on the hippocampal formation, several years after being created, while semantic memories are thought to reside in neocortical areas. The neurobiological substrate of one-time learning and life-long storing in the brain, that must exist at the cellular and circuit level, is still undiscovered. The breakthrough is delayed by the fact that studies jointly investigating the rodent hippocampus and entorhinal cortex are mostly targeted at understanding the spatial aspect of learning. Here we present the concept of an entorhinal cortical module, termed EPISODE module, that could explain how the representations of different elements constituting episodic memories can be linked together. The new model that we propose here reconciles the structural and functional observations made in the entorhinal cortex and explains how the downstream hippocampal processing organizes the representations into meaningful sequences.

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“…However, we hasten to add that these results should be interpreted with caution given the small sample (n = 21) and that they should be replicated in a larger study. Moreover, there is evidence that the medial and lateral portions of ERC play divergent roles in memory 62,68,69 , so it will be important for future studies to segment the ERC into these subsections.…”

Section: Discussionmentioning

confidence: 99%

Links between autobiographical memory richness and temporal discounting in older adults

Lempert¹,

MacNear²,

Wolk³

et al. 2020

Sci Rep

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When making choices between smaller, sooner rewards and larger, later ones, people tend to discount future outcomes. Individual differences in temporal discounting in older adults have been associated with episodic memory abilities and entorhinal cortical thickness. the cause of this association between better memory and more future-oriented choice remains unclear, however. one possibility is that people with perceptually richer recollections are more patient because they also imagine the future more vividly. Alternatively, perhaps people whose memories focus more on the meaning of events (i.e., are more "gist-based") show reduced temporal discounting, since imagining the future depends on interactions between semantic and episodic memory. We examined which categories of episodic details-perception-based or gist-based-are associated with temporal discounting in older adults. older adults whose autobiographical memories were richer in perception-based details showed reduced temporal discounting. furthermore, in an exploratory neuroanatomical analysis, both discount rates and perception-based details correlated with entorhinal cortical thickness. Retrieving autobiographical memories before choice did not affect temporal discounting, however, suggesting that activating episodic memory circuitry at the time of choice is insufficient to alter discounting in older adults. These findings elucidate the role of episodic memory in decision making, which will inform interventions to nudge intertemporal choices. Throughout our lives, we face many intertemporal choices that involve trade-offs between smaller, immediate gains and larger, long-term benefits 1. For example, an individual may have to decide whether or not it is worth paying a fee to withdraw retirement funds early. People generally tend to prefer immediate rewards to delayed ones, and they discount the value of delayed rewards to a greater extent as the delay to receiving them increases. This tendency towards temporal discounting is nearly universal, but the rate at which people discount future rewards varies widely 2,3. Steep temporal discounting, or overvaluing the present at one's long-term expense, is associated with risky behaviors such as alcohol use 4 , gambling 5 , smoking 6,7 , and excessive credit card borrowing 8. Given the substantial negative impact of steep temporal discounting, it is important to understand the neurocognitive mechanisms that underlie intertemporal choices, and to use this knowledge to develop interventions that could reduce impatience. The literature on the neural correlates of temporal discounting points to the involvement of valuation regions 9-11 , executive control regions 12-15 and episodic memory regions 16,17 in this choice process. It remains unclear, however, which of these neurocognitive systems underlies individual differences in the tendency to discount future rewards. One neurocognitive system that may support future-oriented intertemporal choices is episodic memory, or context-rich memory for autobiographical events 1...

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Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory

Cited by 66 publications

References 60 publications

Object and object-memory representations across the proximodistal axis of CA1

Object and object-memory representations across the proximodistal axis of CA1

Episodic memories: how do the hippocampus and the entorhinal ring attractors cooperate to create them?

Links between autobiographical memory richness and temporal discounting in older adults

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