Family size, atopic disorders in parents, asthma in children, and ethnicity

Rona, Roberto J.; Durán-Tauleria, Enric; Chinn, Susan

doi:10.1016/s0091-6749(97)70070-8

Cited by 83 publications

(78 citation statements)

References 22 publications

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“…Our finding confirmed with the study from Turkey which demonstrated that crowding index acts as a risk for asthma occurrence (Yazicioglu et al, 1998). On the other hand overcrowding and large number of siblings combined with unhygienic environmental conditions and increase infections would have a protective effect against asthma (Hygiene Hypothesis) (Douwes &Pearce, 2002;Lau, Kalberg, &Yeung, 1995 andRona, Duran,&Chinn, 1997).Thus, negative association between crowding and asthma was reported by several studies (Alba & Alsina, 1999).The positive association found in our study between crowding index and asthma can be related to genetic etiology and sharing of the same environment.Studying the residency of the students and its relation to asthma, we found that those who are residing in the urban area were having higher rate of asthma similar to results of two studies from UK and Sri Lanka (Karunasekera,Jayasinghe & Alwis , 2001). Our W.,et.al., 2(4) Jul /Sep 2017 (p.75-84) 80 study exhibited that students who reside in urban areas have higher rate of asthma, (29.2%) compared to those in rural area (25.2%).…”

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confidence: 67%

Pediatric Asthma and its Relation to SocioDemographic Factors in Baghdad

Kubaisy

Ali

Thamiri

2017

ajE-Bs

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Asthma is one of the most common chronic diseases of children, causing a huge burden on family and society It"s prevalence has risen sharply over the past 30 years in many parts of the world with large geographical variations. However, in Iraq there is no national database which could be obtained. Due to the increasing number of cases and the burden of this health problem we investigated the sociodemographic and other risk factors related to asthma among primary school children. Modified ISAAC questionnaires were completed by the parents of 2262 children randomly chosen. We found males having higher rat of asthma Bing male be more at risk of developing asthma steadily increasing (27.4%), (28.3%)and (39.5%) with increased (CR) crowding rate (<3, 5 -5,and >5) respectively. only CR of >5 acts as a significant risk factor for asthma. Urbanization acts as significant risk for developing asthma EnvironmentBehaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. https://doi.org/10.21834/aje-bs.v2i4.212 Al -Kubaisy, W.,et.al., / Asian Journal of Environmen-Behaviour Studies, ajE-Bs, 2(4) Jul /Sep 2017 (p.75-84) This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for 76 IntroductionChildhood asthma is a major clinical concern worldwide. It causes a huge burden on family and society. It accounts for a large number of lost school days and may deprive the child of both academic achievement and social interaction. Childhood asthma also places strain on healthcare resources as a result of doctor and hospital visits and cost of treatment (Von, 2000). The prevalence of childhood asthma is increasing worldwide, consequently morbidity and mortality and cost of care continue to increase (Partridge& Alwan, 1997;Ece et al, 2001 andRorstad &Bhatt, 2000.)It has been documented that the prevalence of pediatric asthma has risen sharply over the past 30 years in many parts of the world with large geographical variations (Wood, 2002;Yuan, Basso Sorensen & Oslen, 2002;Douwes &Pearce. 2002). The reasons for this dramatic increase are not yet clear and likely to include multiple contributing factors (Wood, 2002; Anonymous-1-, n.d). These variations are possible due to different exposure to respiratory infections, indoor and /or outdoor pollution, and diet (Von, 2000; Partridge&Alwan,1997). Genetics, lifestyle and environmental factors also may play a role in these variations (Ece. et al, 2001).The prevalence of asthma seems to be higher in affluent than non -affluent populations (Partridge& Alwan, 1997; AlDagwood, 2001).No one really knows why more and more children are developing asthma. Some experts suggest that children are being exposed to more and more allergens such as dust, air pollution, and passive smokers. These are factors that trigg...

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supporting

confidence: 67%

Pediatric Asthma and its Relation to SocioDemographic Factors in Baghdad

Kubaisy

Ali

Thamiri

2017

ajE-Bs

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“…In previous studies, one interpretation of the inverse association between having older sibling(s) and the risk of atopic diseases has been a protective effect of early infections that are more frequent in children with older sibling(s). [1][2][3][4][5][6][7] The present findings indicate that early respiratory infections increase, rather than decrease, the risk of asthma at the age of 4 years, but having older siblings has a protective effect on the risk of asthma, which seems independent from experience of infections. Attendance to a day care center had a small crude effect (OR: 1.2) on the risk of asthma that disappeared after taking into account the early respiratory infections (OR: 1.0).…”

Section: Discussionmentioning

confidence: 49%

“…5,6,11 We were able to assess their effect with and without taking into account the actual occurrence of early respiratory infections. Having older siblings and attendance to a day care center at the age of 1 year increased the risk of bronchial obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] This association has been attributed to a preventive effect of early infections that are suggested to be more common in children with older siblings. This hypothesis is supported by a plausible biologic mechanism, according to which early-life infections stimulate Th1 lymphocytes that may inhibit the expansion of allergen-specific Th2 lymphocytes and may limit the development of allergic diseases.…”

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confidence: 99%

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Early Respiratory Infections and Childhood Asthma

Nafstad¹,

Magnus²,

Jaakkola

2000

Pediatrics

100

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ABSTRACT. Objective. To assess the role of early respiratory infections in the development of bronchial obstruction in the first 2 years of life, and asthma by the age of 4 years in the Oslo Birth Cohort, established in 1992-1993. Having older siblings and attendance to a day care center were also considered as proxy measures of early infections.Methods. A total of 2531 children were followed from birth to 4 years of age. Experiences of respiratory infections were recorded in the follow-up surveys at 6 and 12 months of age, and children with symptoms and signs of bronchial obstruction during the first 2 years of life were identified and examined. The presence of current asthma was recorded when the children were 4 years old.Results. Children with respiratory infections during infancy had a higher risk of having bronchial obstruction during the first 2 years of life and of having asthma at 4 years of age. In logistic regression adjusting for confounders including other infections, the risk of asthma at 4 years of age was related to lower respiratory tract infection (odds ratio ABBREVIATIONS. RSV, respiratory syncytial virus; OR, odds ratio; CI, confidence interval.[

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“…The maternal history of asthma is one of the most studied risk factors for childhood asthma and many studies have defined it as a diagnosis of asthma established at any time during the mother's life [3,[6][7][8]. Using this definition of maternal asthma, the mother might or might not have had asthma during pregnancy.…”

mentioning

confidence: 99%

Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case-control study

Martel

Rey²,

Beauchesne³

et al. 2009

European Respiratory Journal

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The extent to which childhood asthma incidence is influenced by asthma control and severity during pregnancy is unknown. We have studied this association during the child's first 10 yrs of life.A two-stage, case-control study, nested in a cohort of 8,226 children of asthmatic mothers, was conducted using three interlinked databases of Quebec, Canada, and mailed questionnaires. A total of 2,681 asthmatic children and 30,318 age-matched controls were selected (f20 controls?case -1 ; stage 1), and 3,254 selected mothers were mailed questionnaires to obtain additional information (stage 2). Asthma control and severity was defined using validated indexes and childhood asthma incidence based on at least one asthma-related diagnosis and prescription received within 2 yrs. A total of 44 confounders were considered.Compared with children of mild controlled asthmatic mothers, children whose mothers had moderate-to-severe uncontrolled asthma during pregnancy had an increased risk of asthma (adjusted OR 1.27, 95% CI 1.06-1.52). No increased risk was observed for children of mild uncontrolled and moderate-to-severe controlled mothers.Based on one of the largest studies of children of asthmatic mothers, a significant increase in asthma risk was demonstrated among children whose mothers had poor control and increased severity of asthma during pregnancy, indicating that this element should be added to the expanding list of determinants of childhood asthma. As it constitutes a risk factor where pregnant asthmatic females can intervene, it is of great importance for physicians to optimally treat asthmatic females during pregnancy and to encourage females to be adherent to the prescribed asthma medications.

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Family size, atopic disorders in parents, asthma in children, and ethnicity

Cited by 83 publications

References 22 publications

Pediatric Asthma and its Relation to SocioDemographic Factors in Baghdad

Pediatric Asthma and its Relation to SocioDemographic Factors in Baghdad

Early Respiratory Infections and Childhood Asthma

Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case-control study

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