“…[25] Initial development resulted from interviews of family members of patients with 144 different diagnoses across 23 medical specialities, [25,26] and has since been widely validated, demonstrated by high internal consistency (Cronbach's α = 0.80-0.89), and high reproducibility (intraclass correlation = 0.85-0.92) and construct validity, in additional medical conditions, including urological, cancer, COVID-19 and myalgic encephalitis as well as in multiple languages and cultures. [27][28][29][30][31][32][33] Although the FROM-16 is a reliable tool for measuring family impact across a wide range of medical disciplines, it has not yet been applied to a population of ATMP patients and their families, which have some unusual features such as very high treatment costs, often for inherited conditions with others in the family affected but not treated.…”