<span lang="EN-US">Recently, some problems have appeared among medical workers during the diagnosis of some diseases due to human errors or the lack of sufficient information for the diagnosis. In medical diagnosis, doctors always resort to separating human emotions and their impact on vital parameters. In this paper, a methodology is presented to measure vital parameters more accurately while studying the effect of different human emotions on vital signs. Two designs were implemented based on the microcontroller and National Instruments (NI) myRIO. Measurements of four different vital parameters are measured and recorded in real time. At the same time, the effects of different emotions on those vital parameters are recorded and stored for use in analysis and early diagnosis. The results proved that the proposed methodology can contribute to the prediction and diagnosis of the initial symptoms of some diseases such as the seventh nerve and Parkinson’s disease. The two proposed designs are compared with the reference device (beurer) results. The design using NI myRIO achieved more accurate results and a response time of 1.4 seconds for real-time measurements compared to its counterpart based on microcontrollers, which qualifies it to work in intensive care units.</span>