Family of Markwick

Markwick, E. E.

doi:10.1093/nq/s8-iv.90.228e

Cited by 3 publications

(5 citation statements)

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“…2). Popliteal LN responses in the (PVG x AO)Fi-»(DA x AO)Fi combination were not significantly difFerent from the responses in the PVG-"DA combination at day 4 and appeared to be lower on day 6, whereas the PVG->(PVG x AO)Fi response on day 6 was greater and the dose-response plot steeper than in the other combinations as expected from the previous studies [6,19,20].…”

Section: Rfsultssupporting

confidence: 80%

“…simultaneous GVH and HVG. Two independent groups have found that whereas the LNs responding in a GVH reaction expand steadily for 6-7 days after injection, the response in the other two situations dilTers in that the LN weights reach a peak or shoulder at day 4 [6,19,20], The obvious explanation for the curtailment of these reactions at day 4 is the elimination of the donor cells by an HVG reaction. Be that as it may, the continued enlargement of the GVH LN may depend on the host cells sharing an MHC haplotype with initiating donor cells.…”

Section: Rfsultsmentioning

confidence: 99%

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The Stimulus to Host Cell Proliferation in Graft‐versus‐Host Reactions

Ford¹,

Rolstad²,

Fossum³

et al. 1981

Scand J Immunol

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Two experiments are described concerned with the mechanism of host cell activation in the rat popliteal lymph node (LN) undergoing a graft-versus-host (GVH) reaction. (1) Irradiated, F1 hybrid hosts (750 rad) mounted an impaired response to parental strain T cells. This was augmented by an intravenous injection of F1 hybrid lymphocytes but not by parental strain B lymphocytes syngeneic with the initiating T cells. When the donor T cells (footpad) and B lymphocytes (intravenous) were completely allogeneic the residual response of the irradiated F1 was completely inhibited. (2) The popliteal LN response in the semi-allogeneic situation of the type (A x C)F1 leads to (B x C)F1 was, if anything, weaker than in the allogeneic situation AA leads to BB. These results and other data are discussed in terms of a possible major histocompatibility complex (MHC) requirement for host cell activation. The sharing of an MHC haplotype between donor and host cells is unlikely to be a necessary or sufficient condition for host cell activation.

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Section: Rfsultssupporting

confidence: 80%

Section: Rfsultsmentioning

confidence: 99%

The Stimulus to Host Cell Proliferation in Graft‐versus‐Host Reactions

Ford¹,

Rolstad²,

Fossum³

et al. 1981

Scand J Immunol

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“…The allosteric signal has been found to propagate through conserved amino acid residues [17][18][19] and, in general, it is expected to involve physicochemical interactions between "allostery-related" residues that comprise various secondary structure elements, defining (multiple) "allosteric pathways" of the proteic systems. 20 Classical molecular dynamics (MD) simulations provide invaluable information on protein dynamics at atomistic resolution, representing a fundamental tool for the elucidation of such allosteric pathways, [21][22][23] whose experimental detailed characterization is certainly extremely challenging. While MD simulations enclose the dynamical information underpinning the allosteric effects, 24 analyzing complex networks of interactions between (a generally large number of) fluctuating amino acid residues and finding the allosteric signal paths within the wiring of such a network call for help from graph theory techniques.…”

Section: Introductionmentioning

confidence: 99%

Exploring Allosteric Pathways of a V-Type Enzyme with Dynamical Perturbation Networks

et al. 2019

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Elucidation of the allosteric pathways in proteins is a computational challenge that strongly benefits from combination of atomistic molecular dynamics (MD) simulations and coarse-grained analysis of the complex dynamical network of chemical interactions based on graph theory. Here, we introduce and assess the performances of the dynamical perturbation network analysis of allosteric pathways in a prototypical V-type allosteric enzyme. Dynamical atomic contacts obtained from MD simulations are used to weight the allosteric protein graph, which involves an extended network of contacts perturbed by the effector binding in the allosteric site. The outcome showed good agreement with previously reported theoretical and experimental extended studies and it provided recognition of new potential allosteric spots that can be exploited in future mutagenesis experiments. Overall, the dynamical perturbation network analysis proved to be a powerful computational tool, complementary to other network-based approaches that can assist the full exploitation of allosteric phenomena for advances in protein engineering and rational drug design.

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“…The continuum in S stars is due to H − absorption. Water vapor (Markwick & Millar 2000) could contribute at 8 μm but the near-infrared bands have not been detected in ISO/SWS spectra of S stars.…”

Section: Discussionmentioning

confidence: 98%

“…This may be related to the temperature structure of the extended envelope. Figure 3 shows the results of chemical equilibrium calculations (Markwick 2000). These use solar abundance ratios with a varying carbon abundance to obtain a range of C/O ratios.…”

Section: Discussionmentioning

confidence: 99%

THE DETECTION OF INFRARED SiS BANDS IN SPECTRA OF S STARS

Cami

Sloan

Markwick-Kemper

et al. 2008

ApJ

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We present Spitzer spectra of S stars, which are cool evolved stars with a C/O ratio near unity, some of which have enhanced s-process abundances. We present the detection of a strong and unusual band in the mid-infrared, at 13 μm, within the N-band window. Using quantum-chemically calculated line lists, and model spectra, we identify this band as the fundamental rovibrational band of SiS. Detection of the overtone band at 6.7 μm confirms the identification. Fitting the line profile shows that the molecule is located in relatively cool layers, at T ∼ 1500 K. We discuss these results in the context of chemical equilibrium models. The observed strength of these bands in the cool S stars makes them a promising observational diagnostic tool for studying the atmospheres of brown dwarfs and exoplanets.

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Family of Markwick

Cited by 3 publications

References 0 publications

The Stimulus to Host Cell Proliferation in Graft‐versus‐Host Reactions

The Stimulus to Host Cell Proliferation in Graft‐versus‐Host Reactions

Exploring Allosteric Pathways of a V-Type Enzyme with Dynamical Perturbation Networks

THE DETECTION OF INFRARED SiS BANDS IN SPECTRA OF S STARS

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