Family Needs Survey--Japanese Version

Ueda, Kimiko; Bailey, Donald B.; Yonemoto, Naohiro; Kajikawa, Kuniko; Nishigami, Y.; Narisawa, Sachiko; Nishiwaki, Misako; Shibata, Mariko; Tomiwa, Kiyotaka; Matsushita, Akihiro; Fujie, Nodoka; Kodama, Kazuo

doi:10.1037/t68331-000

Cited by 1 publication

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“…OGD/R is an in vitro model widely used to simulate a systemic pathological response caused by ischemia-reperfusion. [33] Therefore, mouse hippocampal neuronal cells HT22 were exposed to OGD for 2 h and reoxygenation for 24 h for in vitro studies. The F I G U R E 1 circCDC14A was upregulated in the mice and cell models of CI/R injury.…”

Section: Circcdc14a Was Upregulated In the Mice And Cell Models Of Ci...mentioning

confidence: 99%

Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis

Huo

et al. 2022

J Biochem & Molecular Tox

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Ischemic stroke is one of the main causes of death and disability. Circular RNAs (circRNAs) have received extensive attention in the pathogenesis of ischemic stroke. Here, we evaluated the role of circCDC14A in cerebral ischemia-reperfusion (CI/R) injury in vivo and in vitro. The expression of circCDC14A was significantly upregulated in the middle cerebral artery occlusion (MCAO) model and oxygen and glucose deprivation/reoxygenation (OGD/R)-treated HT22 cells. Knockdown of circCDC14A suppressed the cell viability reduction caused by OGD/R, as well as cell damage and apoptosis. Mechanistically, circCDC14A acted as a sponge for miR-23a-3p and promoted the expression of chemokine stromal-derived factor-1 (CXCL12) by negatively regulating miR-23a-3p.Rescue experiments further confirmed that miR-23a-3p inhibitor or circCDC14Aoverexpression vectors blocked the beneficial effects of circCDC14A knockdown in OGD/R-induced HT22 cells. Moreover, knockdown of circCDC14A suppressed MCAOinduced cerebral infarction and neurological damage, as well as the brain tissue damage and neuronal apoptosis in vivo. Consistently, miR-23a-3p antagomir treatment abolished the cerebral protective effects of circCDC14A knockdown on MCAO mice. In conclusion, circCDC14A promoted CI/R injury by regulating the miR-23a-3p/CXCL12 axis, which suggested that circCDC14A may become a potential therapeutic target for CI/R injury.

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Section: Circcdc14a Was Upregulated In the Mice And Cell Models Of Ci...mentioning

confidence: 99%

Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis

Huo

et al. 2022

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

Family Needs Survey--Japanese Version

Cited by 1 publication

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Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis

Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis

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