Family Myrtaceae: The treasure hidden in the complex/diverse composition

Saber, Fatema R.; Munekata, Paulo E.S.; El-Nashar, Heba A. S.; Fahmy, Nouran M.; Aly, Shaza H.; El‐Shazly, Mohamed; Bouyahya, Abdelhakim; Lorenzo, José M.

doi:10.1080/10408398.2023.2173720

Cited by 15 publications

(11 citation statements)

References 140 publications

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“…Our ancestors were totally dependent on a wide variety of plants to treat themselves from disease until the introduction of synthetic medicines. – It is found that almost 2000 racial groups all over the world have their own unique medical understanding and experience. , This is because some vital components that possess antioxidant and anti-inflammatory properties are used in certain physiologic conditions . There were 90 drugs that are commercially available or approved worldwide in the period of 1982 to 2002, and 79% of them were from natural sources. – Still a large portion of the population use medicinal plants as primary source to treat different diseases such as fever, pain, inflammation, diarrhea, and many other illnesses. , …”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and In Vivo Hepatoprotective Properties of Wissadula periplocifolia Extract

Hossain,

Islam,

Rahman

et al. 2023

ACS Omega

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Wissadula periplocifolia (L.) Thwaites is a traditional medicinal plant belonging to the family Malvaceae, used in folk medicine for inflamed snake bites and bee stings. The current study was designed to investigate the in vitro antioxidant and in vivo anti-inflammatory and hepatoprotective activities of 80% ethanol extract of W. periplocifolia and its different fractions. The crude ethanolic extract (CEE) was then serially fractionated with petroleum ether fraction (PEF), chloroform fraction (CHF), and aqueous fraction (AQF). The antioxidant activity was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay, anti-inflammatory activity was determined in the xylene-induced ear edema model, and hepatoprotective activity was measured in the paracetamol-induced hepatic injury model. PEF showed a significant scavenging effect with an IC 50 value of 33.5 μg/mL, followed by CEE (IC 50 = 42.2 μg/mL), CHF (IC 50 = 77 μg/mL), and AQF (IC 50 = 80 μg/mL), compared to standard butylated hydroxytoluene (IC 50 = 14.8 μg/mL). Both doses of CEE (250 and 500 mg/kg) could reduce ear edema by 41.3 and 50%, respectively, compared to standard diclofenac sodium (76.09%). Moreover, CEE significantly reduces the elevated liver enzymes (ALT, AST, and ALP), compared to control. Nevertheless, it elevated blood protein and reduced the blood bilirubin level ( p < 0.01), compared to control. Histopathological studies also indicated significant protection of the liver from paracetamol-induced liver damage. In conclusion, W. periplocifolia could be a good source of antioxidant and hepatoprotective phytochemicals; meanwhile, toxicological and pharmacokinetic studies are recommended.

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Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and In Vivo Hepatoprotective Properties of Wissadula periplocifolia Extract

Hossain,

Islam,

Rahman

et al. 2023

ACS Omega

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“…Aloe vera [ 8 ], Calendula officinal [ 9 ], curcumin [ 10 ] and essential oils represent prominent examples with great contributions in one or more stages of the process of wound healing [ 1 , 11 ]. The efficacy of the different medicinal plants in wound healing could be related to the different classes of the secondary metabolites biosynthesised by medicinal plants, including triterpenoids, sterols (anti-inflammatory), flavonoids, polyphenolics (antioxidants), alkaloids (antimicrobial, anti-inflammatory) and/or essential oils (antimicrobial, anti-inflammatory) [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

et al. 2023

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Glycyrrhiza glabra and Sophora japonica (Fabaceae) are well-known medicinal plants with valuable secondary metabolites and pharmacological properties. The flavonoid-rich fractions of G. glabra roots and S. japonica leaves were prepared using Diaion column chromatography, and the confirmation of flavonoid richness was confirmed using UPLC-ESI-MS profiling and total phenolics and flavonoids assays. UPLC-ESI-MS profiling of the flavonoid-rich fraction of G. glabra roots and S. japonica leaves resulted in the tentative identification of 32 and 23 compounds, respectively. Additionally, the wound healing potential of topical preparations of each fraction, individually and in combination (1:1) ointment and gel preparations, were investigated in vivo, supported by histopathological examinations and biomarker evaluations, as well as molecular docking studies for the major constituents. The topical application of G. glabra ointment and gel, S. japonica ointment and gel and combination preparations significantly increase the wound healing rate and the reduction of oxidative stress in the wound area via MDA reduction and the elevation of reduced GSH and SOD levels as compared to the wound and Nolaver®-treated groups. The molecular docking study revealed that that major compounds in G. glabra and S. japonica can efficiently bind to the active sites of three proteins related to wound healing: glycogen synthase kinase 3-β (GSK3-β), matrix metalloproteinases-8 (MMP-8) and nitric oxide synthase (iNOS). Consequently, G. glabra roots and S. japonica leaves may be a rich source of bioactive metabolites with antioxidant, anti-inflammatory and wound healing properties.

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“…The Myrtaceae family is one of the most diverse and abundant botanical families on the planet, [1,2] with over 6000 species distributed across 140 genera and occurring throughout the equatorial region, including South America, Asia, and Australia. [3,4] In Brazil, there are approximately 29 genera, including native and introduced species.…”

Section: Introductionmentioning

confidence: 99%

“…[6] All of these potential applications can be associated with their wide chemical diversity. [1,7] The volatiles of essential oils (EOs) are products of plant metabolism that are commonly associated with secondary metabolites. [8] In general, the chemical diversity of EOs is high in species of the Myrtaceae family, with the predominance of sesquiterpenes in most species, mainly selinene, germacrene, 1,8-cineole, and p-cymene.…”

Section: Introductionmentioning

confidence: 99%

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Larvicidal and Fungicidal Activity of the Leaf Essential Oil of Five Myrtaceae Species

dos Santos,

da Fonseca Rezende,

dos Santos

et al. 2023

Chemistry & Biodiversity

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Myrtaceae is one of the most diverse and abundant botanical families, exhibiting wide diversity in the chemical composition of essential oils (EOs). EOs have various biotechnological applications such as controlling the populations of organisms that negatively impact humans. This study aimed to extract EOs from Myrtaceae species, chemically characterize them, and evaluate their larvicidal and fungicidal effects. EOs were extracted from the leaves of Eugenia brasiliensis, Eugenia uniflora, Psidium cattleyanum, Psidium guajava, and Syzygium cumini by hydrodistillation for 3 h and characterized by chromatographic analysis. Larvaes of Aedes aegypti and colonies of Fusarium oxysporum were subjected to increasing EO concentrations to determine the larvicidal and fungicidal potential. The EOs of Eugenia and Psidium species are primarily composed of sesquiterpenes (>80 %), whereas S. cumini EO is rich in monoterpenes (more than 60 %). The Eugenia species had similar amounts of oxygenated monoterpenes, which may explain their higher larvicidal potential compared to other species, with CL50 of 86.68 and 147.46 PPM, respectively. In addition to these two study species, S. cumini showed a high inhibition of fungal growth, with more than 65 % inhibition. We demonstrated that the actions of five EOs from Myrtaceae with different biological activities are associated with chemical diversity.

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Family Myrtaceae: The treasure hidden in the complex/diverse composition

Cited by 15 publications

References 140 publications

In Vitro Antioxidant and In Vivo Hepatoprotective Properties of Wissadula periplocifolia Extract

In Vitro Antioxidant and In Vivo Hepatoprotective Properties of Wissadula periplocifolia Extract

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

Larvicidal and Fungicidal Activity of the Leaf Essential Oil of Five Myrtaceae Species

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