Family History, the Electroencephalogram and Perinatal Factors in Manic Conditions

Dalén, Per

doi:10.1111/j.1600-0447.1965.tb06169.x

Cited by 69 publications

(15 citation statements)

References 86 publications

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“…Investigating mania, and using a very similar approach but with the refinement of studying perinatal hazards as well as electroencephalographic variants, Dalen (1965) reported that the presence of a family history of affective illness correlated negatively with paroxysmal theta activity and asymmetrical activity, while perinatal hazards correlated positively with 'abnormal or borderline' records. After detailed argument, he concluded, inter alia, that his data supported the hypothesis that a genetic propensity operated in some cases, and, in others, brain damage.…”

Section: Resultsmentioning

confidence: 99%

Electroencephalographic variants and genetic predisposition to schizophrenia.

Hays¹

1977

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Schizophrenic patients (249) were divided into those with and those without a family history of major functional psychosis. The same patients were then divided into those with entirely normal electroencephalograms and those whose traces contained some variant of normal. Traces were interpreted without knowledge of the patients' identities, and the question of the presence or absence of positive heredity had been decided without knowledge of the patients' electroencephalographic status, so that the discovery that normal electroencephalograms correlated highly significantly with positive heredity, and vice versa, commands attention. It is considered in the setting of previous work on psychoses and organic and electroencephalographic findings.

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Section: Resultsmentioning

confidence: 99%

Electroencephalographic variants and genetic predisposition to schizophrenia.

Hays¹

1977

Journal of Neurology, Neurosurgery & Psychiatry

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“…In the meantime, Dalen and colleagues distinguished bipolar patients with normal EEG as likely to be familial cases whereas those with EEG abnormalities were secondary to some form of central nervous system insult (Dalen et al 1965). Although a negative study was reported (Taylor 1980), subsequent researchers also confirmed this relationship between EEG and family history (Kadrmas and Winokur 1979;).…”

Section: Lithiummentioning

confidence: 99%

Standard EEG: A Research Roadmap for Neuropsychiatry

Boutros¹

2013

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“…These studies suggest that EEG abnormality is a possible predictor of lithium resistance in bipolar disorder. In the meantime, Dalen distinguished bipolar patients with normal EEG as likely to be familial cases whereas those with EEG abnormalities were secondary to some form of central nervous system insult 18 . Although a negative study was reported, 19 subsequent researchers also confirmed this relationship between EEG and family history 20–22 .…”

Section: Electroencephalography Finding and Event‐related Potentialsmentioning

confidence: 99%

Biological predictors of lithium response in bipolar disorder

Ikeda

Kato

2003

Psychiatry Clin Neurosci

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In order to prescribe lithium appropriately to patients with bipolar disorder, predictors of lithium response are helpful. The present paper reviews the biological predictors of lithium response. As a positive predictor of lithium response, the following have been reported: strong loudness dependence of the auditory-evoked N1/P2-response; higher brain lithium concentration; lower inositol monophosphatase (IMPase) mRNA expression; higher serotonin-induced calcium mobilization; increased N -acetyl-aspartate peak and decreased myo-inositol peak; white matter hyperintensity; decreased intracellular pH; higher frequency of phospholipase C g -1 ( PLCG1 )-5 repeat and PLCG1 -8 repeat; and C973A polymorphism in the inositol polyphosphate 1-phosphatase gene. In contrast the following have been reported as a predictor of negative lithium response: epileptiform abnormality of electroencephalography; human leukocyte antigen type A3; decreased phosphocreatine peak area after photic stimulation; and homozygotes for the short variant of the serotonin transporter gene. Most of the possible biological predictors of better lithium response, such as lower IMPase mRNA levels, white matter hyperintensity, lower brain intracellular pH, enhanced calcium response, and PLCG1 -5 repeat had been detected as risk factors for bipolar disorder, suggesting that bipolar disorder responding well to maintenance lithium treatment is a distinct category having a certain neurobiological basis, although these findings need further replication. The search for biological predictors of lithium response is still in its infancy. Most of the laboratory or neuroimaging techniques used in these studies are not easily performed in clinical settings, so the development of an easy and useful laboratory test is needed.

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Family History, the Electroencephalogram and Perinatal Factors in Manic Conditions

Cited by 69 publications

References 86 publications

Electroencephalographic variants and genetic predisposition to schizophrenia.

Electroencephalographic variants and genetic predisposition to schizophrenia.

Standard EEG: A Research Roadmap for Neuropsychiatry

Biological predictors of lithium response in bipolar disorder

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