Family history of type 2 diabetes and characteristics of children with newly diagnosed type 1 diabetes

Parkkola, Anna; Turtinen, Maaret; Härkönen, Taina; Ilonen, Jorma; Knip, Mikael

doi:10.1007/s00125-020-05342-x

Cited by 12 publications

(11 citation statements)

References 44 publications

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“…In detail, the CMEFC who had excellent health statuses were more likely to have GMEFC with excellent health statuses, and the MEFC who had excellent health statuses were more likely to have GMEFC with excellent health statuses. Our results above were similar to a study in Kenya which showed that mothers who were overweight or obese had higher odds of having children who were overweight or obese [ 43 ], as well as research in Finland that found the children who had newly diagnosed type 1 diabetes were influenced by grandparents with type 2 diabetes [ 44 ]. Moreover, a study in the U.S. found that grandmothers who were underweight prior to pregnancy had an increased risk of attention-deficit/hyperactivity disorder among their grandchildren [ 45 ].…”

Section: Discussionsupporting

confidence: 90%

The Effects of Living Environment, Health Status of Family Members, and Migrant Elderly following Children’s Attitude about Care on Grandchildren’s Health Status in Weifang, China

et al. 2022

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As urbanization is growing quickly in China, many of the migrant elderly following children (MEFC) have migrated to big cities to care for their grandchildren (grandchildren of MEFC=GMEFC). This study aimed to explore the effects of the living environment, health statuses of family members, and MEFC’s attitude regarding the care of their children (children of MEFC=CMEFC) for their GMEFC on GMEFC’s health statuses in Weifang, China. Multistage cluster random sampling was used to select the participants, and 613 MEFC were included in total. A descriptive analysis, a univariate analysis and a binary logistic regression were used to investigate the association between the related variables and GMEFC’s health statuses. It was found that 74.9% of the GMEFC had excellent health statuses. The GMEFC who had siblings, the CMEF with excellent health statuses, and the MEFC with excellent health statuses were more likely to have GMEFC with excellent health statuses. Moreover, the GMEFC who were female or occasionally had elevators that malfunctioned, the MEFC who were dissatisfied with the CMEFC’s time spent on caring, and the MEFC who did not understand or forgive the CMEFC’s limited time on caring were less likely to have GMEFC with excellent health statuses. The results indicated that a better living environment, better health statuses of family members, and a positive attitude of the MEFC regarding the care of the CMEFC for the GMEFC result in a better health status of the GMEFC.

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Section: Discussionsupporting

confidence: 90%

The Effects of Living Environment, Health Status of Family Members, and Migrant Elderly following Children’s Attitude about Care on Grandchildren’s Health Status in Weifang, China

et al. 2022

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“…When it came to T2D, higher BMI and worse lipid profile were associated with family history of T2D. As consistent with previous studies on autoimmune T1D, patients with a family history of T2D had an older onset age, 15,17,18 a higher BMI, 15,16,18 and an increased risk of diabetic complications 18‐20 …”

Section: Discussionsupporting

confidence: 86%

“…43,44 When it came to T2D, higher BMI and worse lipid profile were associated with family history of T2D. As consistent with previous studies on autoimmune T1D, patients with a family history of T2D had an older onset age, 15,17,18 a higher BMI, 15,16,18 and an increased risk of diabetic complications. [18][19][20] Several studies have been conducted to investigate the potential mechanisms underlying the aforementioned implications of family history of T2D.…”

Section: Discussionsupporting

confidence: 84%

“…A few studies have found that family history of T2D was associated with a metabolic profile related to insulin resistance and a greater risk of diabetic complications in T1D patients. [15][16][17][18] However, the majority of studies did not test autoantibodies for diagnosis, 16,17,19,20 and the rest included patients with autoimmune T1D as the majority (76%-97.6%) of their study populations. 15,18,21 The impact of family history of T2D on idiopathic T1D is completely unknown.…”

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confidence: 99%

“…[15][16][17][18] However, the majority of studies did not test autoantibodies for diagnosis, 16,17,19,20 and the rest included patients with autoimmune T1D as the majority (76%-97.6%) of their study populations. 15,18,21 The impact of family history of T2D on idiopathic T1D is completely unknown. Moreover, the definition of idiopathic T1D is controversial, as a significant proportion of monogenic diabetes in T1D patients with negative autoantibodies must be ruled out.…”

mentioning

confidence: 99%

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The impact of family history of type 2 diabetes on clinical heterogeneity in idiopathic type 1 diabetes

Chen

Wang

Xie

et al. 2022

Diabetes Obesity Metabolism

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Aim: To investigate the impact of family history of type 2 diabetes (T2D) on the clinical phenotypes of patients with idiopathic type 1 diabetes (T1D). Methods:In clinically diagnosed T1D cases, a total of 335 idopathic T1D patients were included in the study, after excluding autoimmune T1D using islet autoantibody testing and monogenic diabetes using a custom monogenic diabetes gene panel obtained from clinically diagnosed T1D cases. A semi-structured questionnaire was used to collect information on the presence of T2D in first-degree relatives. The demographic and metabolic markers of idiopathic T1D patients were analysed. Subgroup analysis was performed to investigate potential interactions between T2D family history and human leukocyte antigen (HLA) genotypes.Results: A total of 18.2% of individuals with idiopathic T1D had a T2D family history, and these individuals were more likely to have features associated with T2D, such as older age of onset, higher body mass index at diagnosis, lower insulin dosage and better beta-cell function, as indicated by higher levels of fasting C-peptide and 2-hour postprandial C-peptide (all P < 0.05). Additionally, regardless of HLA susceptible genotypes, the impact of family history of T2D was consistently observed in idiopathic T1D patients. Multivariable analyses showed that T2D family history was negatively correlated with the risk of beta-cell function failure in idiopathic T1D patients (P < 0.05).Conclusions: Family history of T2D may be implicated in the heterogeneity of idiopathic T1D patients.

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Prevalence, clinical characteristics and HLA genotypes of idiopathic type 1 diabetes: A cross‐sectional study

Chen

Xie

Xia

et al. 2023

Diabetes Metabolism Res

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AimsIdiopathic type 1 diabetes (T1D) is a neglected subtype of T1D. Our aim was to investigate the frequency, clinical characteristics, and human leucocyte antigen (HLA) genotypes of idiopathic T1D.MethodsWe enrolled 1205 newly diagnosed T1D patients in our analysis. To exclude monogenic diabetes in autoantibody‐negative patients, we utilised a custom monogenic diabetes gene panel. Individuals negative for autoantibodies and subsequently excluded for monogenic diabetes were diagnosed with idiopathic T1D. We collected clinical characteristics, measured islet autoantibodies by radioligand assay and obtained HLA data.ResultsAfter excluding 11 patients with monogenic diabetes, 284 cases were diagnosed with idiopathic T1D, accounting for 23.8% (284/1194) of all newly diagnosed T1D cases. When compared with autoimmune T1D, idiopathic T1D patients showed an older onset age, higher body mass index among adults, lower haemoglobin A1c, higher levels of fasting C‐peptide and 2‐h postprandial C‐peptide, and were likely to have type 2 diabetes (T2D) family history and carry 0 susceptible HLA haplotype (all p < 0.01). A lower proportion of individuals carrying 2 susceptible HLA haplotypes in idiopathic T1D was observed in the adult‐onset subgroup (15.7% vs. 38.0% in child‐onset subgroup, p < 0.001) and in subgroup with preserved beta‐cell function (11.0% vs. 30.1% in subgroup with poor beta‐cell function, p < 0.001). Multivariable correlation analyses indicated that being overweight, having T2D family history and lacking susceptible HLA haplotypes were associated with negative autoantibodies.ConclusionsIdiopathic T1D represents about 1/4 of newly diagnosed T1D, with adult‐onset and preserved beta‐cell function patients showing lower HLA susceptibility and more insulin resistance.

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Family history of type 2 diabetes and characteristics of children with newly diagnosed type 1 diabetes

Cited by 12 publications

References 44 publications

The Effects of Living Environment, Health Status of Family Members, and Migrant Elderly following Children’s Attitude about Care on Grandchildren’s Health Status in Weifang, China

The Effects of Living Environment, Health Status of Family Members, and Migrant Elderly following Children’s Attitude about Care on Grandchildren’s Health Status in Weifang, China

The impact of family history of type 2 diabetes on clinical heterogeneity in idiopathic type 1 diabetes

Prevalence, clinical characteristics and HLA genotypes of idiopathic type 1 diabetes: A cross‐sectional study

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