Family history of type 2 diabetes and prevalence of metabolic syndrome in adult Asian Indians

Abstract

Background:Our objective was to test the association between familial risk of type 2 diabetes mellitus (T2DM) and the prevalence of metabolic syndrome (MS) in adult Asian Indians.Materials and Methods:A total of 448 adult (>30 years) individuals (257 males and 191 females) participated in the study. Familial risk of T2DM was classified into three groups viz., 1=both parents affected; 2=parent and/or siblings affected and 3=none or no family history for T2DM. Anthropometric measures, blood pressures, fasting blood glucose and metabolic profiles were studied using standard techniques. MS was defined accordingly. The prevalence of MS phenotypes was estimated and compared among the three familial risk strata.Results:Individuals with a history of both parents affected from diabetes had significantly higher (P<0.001) body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and fasting blood glucose (FBG; P=0.035) than individuals having no family history of T2DM. Significant difference was also noticed between individuals with and without MS according to the family history of diabetes (P<0.001). Differences were evident between individuals who fulfilled all the MS criteria (P=0.001) and individuals with only one or two criteria (phenotypes) according to family history of T2DM.Conclusion:Family history of T2DM had significant effect on individuals with MS as compared to their counterparts (individuals having no family history of T2DM). It therefore seems reasonable to argue that family history of T2DM could be useful as a predictive tool for early diagnosis and prevention of MS in Asian Indian population.

A cross-sectional study on risk factors for Type 2 diabetes mellitus in rural population of Davangere

“…In this study, more females have Type 2 diabetes compared to male which was found to be statistically significant, whereas, in the WHO report in southeast Asia, more male diabetics have been observed. [2] Several studies showed increased risk of diabetes with positive family history of diabetes, [14,20,21] but in the present study, there was no significant association between family history of diabetes and RBS level this may be due to majority of study participants parents or siblings were not screened for diabetes and awareness about screening for diabetics was found to be poor.…”

Association between Socio-Demographic Factors and Blood Sugar Levels in Type 2 Diabetes Mellitus Patients in Bangladesh

“…The family history of specific diseases reflects the consequences of genetic susceptibility, shared environment and common behaviors [23]. The area of residence has an effect on the level of metabolic control, the occurrence of diabetic complications, and quality of life.…”

Study of Metabolic Syndrome and Its Risk Components in Patients Attending Tertiary Care Center of Uttarakhand

“…We found that 31 % of diabetic patients were having MS. An earlier study had found that 62 % of newly diagnosed T2DM patients were having MS according to IDF criteria [34] and it has also been suggested that family history of T2DM can be useful predictor for diagnosis of MS [35]. It is known that impaired fasting glucose is a risk factor for diabetes and both are known to be associated closely with obesity, though the mechanism behind this is not confirmed yet [36].…”