Family history of type 2 diabetes is increased in patients with type 1 diabetes

Barone, Bianca; Rodacki, Melanie; Zajdenverg, Lenita; Almeida, Mirella Hansen de; Cabizuca, Carolina A.; Barreto, Dolores; Araújo, Larissa Fortunato; Kupfer, Rosane; Milech, Adolpho; Oliveira, José Egídio Paulo de

doi:10.1016/j.diabres.2008.03.015

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…This is in agreement with that reported by Barone et al [27], who showed a more frequent positive family history of type 2 diabetes rather than type 1 diabetes or both.…”

Section: Discussionsupporting

confidence: 93%

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Hassan

Hafez

Koura³

et al. 2015

Medical Research Journal

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Objective The aim of this study was to identify the etiology, risk factors, and the most common clinical features of newly diagnosed diabetes in children and adolescents, in addition to the factors related to delayed diagnosis or mismanagement in these children.Materials and methods Ninety-nine children and adolescents aged from one month to 13 years with newly diagnosed type 1 diabetes (T1DM) were recruited from the inpatient department of the Diabetic, Endocrine, and Metabolic Pediatric Unit (DEMPU), New Children Hospital, Cairo University.Results Classic symptoms (polyuria and polydipsia, and weight loss) were the most common symptoms (the first two symptoms in 95.9 and the last one in 90.7%) preceding the diagnosis, and diabetic ketoacidosis was present in 51.5% of cases. Delayed and missed diagnosis was recorded in 49.5% of patients, with no significant relation with age, district of accommodation, or family history of diabetes. Cow's milk feeding was more frequent, being recorded in 75.2% vs. 19.6% with exclusive breast feeding, and positive family history of diabetes was recorded in 77.3%. Severity at presentation showed no significant relation with age, type of feeding, family history of diabetes, or C-peptide level.Conclusion Increased public awareness of early symptoms of diabetes is needed to reduce the frequency and severity of ketoacidosis. In addition, greater medical alertness to the possibility of T1DM in a young child should be stressed. Breastfeeding and avoidance of early cow milk introduction should be encouraged to decrease the risk for T1DM during infancy with its early complications and morbidity.

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“…This is in agreement with that reported by Barone et al [27], who showed a more frequent positive family history of type 2 diabetes rather than type 1 diabetes or both.…”

Section: Discussionsupporting

confidence: 93%

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Hassan

Hafez

Koura³

et al. 2015

Medical Research Journal

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“…In literature; in adult population, Barone et al [3], in studying the families of subjects with T1DM, found a positive family history for T1DM in 13.8% of FDR and 6.2% of second/third relative (S/TDR); whereas for T2DM, 25.5% were found in FDR and 40.7% in S/TDR. Other studies that looked at younger and Caucasian subjects, found that 2.6% of FDR (parents) had T1DM and 2.4% had T2DM [29].…”

Section: Discussionmentioning

confidence: 95%

Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus

et al. 2011

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The prevalence of autoimmune thyroid disease in type 1 diabetic patients is higher than in the general population. A routine screening strategy should be implemented with the determination of anti-thyroid antibodies and TSH in type 1 diabetic patients, particularly in girls, and in patients with diabetes of more than 5 years duration. Patients who have positive TPO antibodies may need the assessment of thyroid function at shorter intervals.

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“…The effects of weight gain may be intensified when not accompanied by good glycemic control. It has been postulated that a first-degree family history of T2D, already reported to be higher in Brazilian patients with T1D compared to non-diabetic patients [26], predisposes these patients to a higher risk of weight gain and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study

Cobas

Santos

Silva

et al. 2011

Diabetol Metab Syndr

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BackgroundThe presence of microalbuminuria can be associated with overt nephropathy and cardiovascular disease in patients with type 1 diabetes (T1D). We aimed to determine the incidence and evaluate the baseline predictors for the development of microalbuminuria in patients with T1D.MethodsThis study is a longitudinal cohort study of 122 normoalbuminuric patients with T1D who were receiving routine clinical care at baseline. A detailed medical history was taken, and a physical examination was performed at baseline. All of the patients were regularly examined for diabetes-associated complications. An analysis of predictors was performed using the Cox regression.ResultsOver 6.81 (3.59-9.75) years of follow-up, 50 (41%) of the patients developed microalbuminuria. The incidence density was 6.79/100 people per year (95% CI 5.04-8.95), and the microalbuminuria developed after 5.9 (2.44-7.76) and 11 (5-15) years of follow-up and diabetes duration, respectively. After an individual Cox regression, the baseline variables associated with the development of microalbuminuria were age, age at diagnosis, duration of diabetes, systolic and diastolic blood pressure, fasting glycemia, body mass index (BMI), total cholesterol and triglycerides levels, cholesterol/HDL ratio and a family history of type 2 diabetes.After a multivariate Cox regression, the only independent factors associated with the development of microalbuminuria were BMI [HR 1.12 (1.03-1.21)] and cholesterol/HDL ratio [HR 1.32 (1.05-1.67)].ConclusionsA higher BMI and cholesterol/HDL ratio increased the risk of developing microalbuminuria in young patients with T1D after a short follow-up. Both risk factors are modifiable and should be identified early and followed closely.

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Family history of type 2 diabetes is increased in patients with type 1 diabetes

Cited by 14 publications

References 24 publications

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus

Progression to microalbuminuria in patients with type 1 diabetes: a seven-year prospective study

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