Family history of suicidal behavior and early traumatic experiences: Additive effect on suicidality and course of bipolar illness?

Carballo, Juan J.; Harkavy‐Friedman, Jill; Burke, Ainsley K.; Sher, Leo; Baca‐García, Enrique; Sullivan, Gregory M.; Grunebaum, Michael F.; Parsey, Ramin V.; Mann, J. John; Oquendo, María A.

doi:10.1016/j.jad.2007.12.225

Cited by 101 publications

(65 citation statements)

References 42 publications

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“…The few studies which have focused upon social factors and suicidality in bipolar disorder have highlighted the significance of adversities during early life, such as childhood physical and sexual abuse (Alvarez et al, 2011;Carballo et al, 2008;Garno et al, 2005;Leverich et al, 2002), a family history of suicidal behaviour (Galfalvy et al, 2006;Leverich et al, 2002;MacKinnon et al, 2005;Pawlak et al, 2013), a family history of mental health problems (Lopez et al, 2001;Pawlak et al, 2013), problems with social relationships (Leverich et al, 2002;Tsai et al, 1999), and stressful life events (Antypa et al, 2013;Azorin et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

A qualitative investigation into the relationships between social factors and suicidal thoughts and acts experienced by people with a bipolar disorder diagnosis

Owen

Gooding

Dempsey

et al. 2015

Journal of Affective Disorders

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractBackground: The prevalence rate of completed suicide in bipolar disorder is estimated to be as high as 19%. Social factors or influences, such as stigmatisation and family conflict, contribute to the development of suicidal ideation in clinical and non-clinical populations. Yet, there is a lack of studies examining suicidality from a psychosocial perspective in people who experience bipolar disorder.Method: Semi-structured interviews were used to collect qualitative data from 20 participants with bipolar disorder. The interview focused on the effects of social factors upon participants" experiences of suicidality (suicidal thoughts, feelings or behaviours). A thematic analysis was used to understand the data.Results: Social or interpersonal factors which participants identified as protective against suicidality included, 'the impact of suicide on others' and, 'reflecting on positive social experiences'. Social factors which triggered suicidal thoughts included, 'negative social experiences' and, 'not being understood or acknowledged'. Social factors which worsened suicidal thoughts or facilitated suicidal behaviour were, 'feeling burdensome," and 'reinforcing negative self-appraisals'.Limitations: Some participants had not experienced suicidal thoughts for many years and were recalling experiences which had taken place over ten years ago. The accuracy and reliability of these memories must therefore be taken into consideration when interpreting the results. Conclusions:The themes help to enhance current understanding of the ways in which social factors affect suicidality in people who experience bipolar disorder. These results highlight the importance of considering the social context in which suicidality is experienced and incorporating strategies to buffer against the effects of negative social experiences in psychological interventions which target suicide risk in bipolar disorder.

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Section: Introductionmentioning

confidence: 99%

A qualitative investigation into the relationships between social factors and suicidal thoughts and acts experienced by people with a bipolar disorder diagnosis

Owen

Gooding

Dempsey

et al. 2015

Journal of Affective Disorders

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“…[38][39][40][41] For example, suicide attempts and bipolar disorder severity have been linked to childhood sexual (CSA) and physical abuse (CPA). [42][43][44] Primate studies suggest that early life adversity alters stress sensitivity-a feature of both SBs and MDs-compromising serotonergic neurotransmission. 45,46 Stress is, for example, associated with SLC6A4 mRNA level 47 and harsh parenting to HTR2A receptor density.…”

Section: Introductionmentioning

confidence: 99%

Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study

et al. 2009

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To investigate similarities and differences in the serotonergic diathesis for mood disorders and suicide attempts, we conducted a study in a cohort followed longitudinally for 22 years. A total of 1255 members of this cohort, which is representative of the French-speaking population of Quebec, were investigated. Main outcome measures included (1) mood disorders (bipolar disorder and major depression) and suicide attempts by early adulthood; (2) odds ratios and probabilities associated with 143 single nucleotide polymorphisms in 11 serotonergic genes, acting directly or as moderators in gene-environment interactions with childhood sexual or childhood physical abuse (CPA), and in gene-gene interactions; (3) regression coefficients for putative endophenotypes for mood disorders (childhood anxiousness) and suicide attempts (childhood disruptiveness). Five genes showed significant adjusted effects (HTR2A, TPH1, HTR5A, SLC6A4 and HTR1A). Of these, HTR2A variation influenced both suicide attempts and mood disorders, although through different mechanisms. In suicide attempts, HTR2A variants (rs6561333, rs7997012 and rs1885884) were involved through interactions with histories of sexual and physical abuse whereas in mood disorders through one main effect (rs9316235). In terms of phenotype-specific contributions, TPH1 variation (rs10488683) was relevant only in the diathesis for suicide attempts. Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders, nor did childhood disruptiveness mediate the effects of TPH1 on suicide attempts. Of the serotonergic genes implicated in mood disorders and suicidal behaviors, four exhibited phenotype-specific effects, suggesting that despite their high concordance and common genetic determinants, suicide attempts and mood disorders may also have partially independent etiological pathways. To identify where these pathways diverge, we need to understand the differential, phenotype-specific gene-environment interactions such as the ones observed in the present study, using suitably powered samples.

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“…Bu birlikteliğin duygudurum değişimleri ve özkıyım girişimlerinde artışa sebep olmakla birlikte, belirgin olarak yaşam kalitesinde bozulmayla ilişkili olduğu bildirilmiştir. [40] Borderline kişilik bozukluğu ise genel toplumda %2, ayaktan başvuran psikiyatrik olgularda %10, psikiyatri servislerinde yatırılan olgularda %20 oranında olduğu görül-mektedir. [41] Yapılan bir metaanaliz çalışmasında borderline kişilik bozukluğu etyolojisinde istismarın önemli bir sebep olduğu biçimindeki düşünce desteklenmiş, tek etken olmamakla birlikte bu bozukluğun önemli bir risk etmeni olduğu bildirilmiştir.…”

Section: Psikiyatrik Bozukluklarunclassified

Residential Treatment Centers for Child Abuse

Nasıroğlu¹

2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖzetHer yıl çocuklara yönelik istismar ve ihmal konusunda milyonlarca rapor düzenlenmekte ve adli davalar yürütülmektedir. Çocuklara yönelik istismarın tarihin bilinen tüm dönemlerinde yaşandığını görmekteyiz. Çocuk istismarının ve ihmalinin mağdur çocuklar üzerinde önemli ve kalıcı etkileri olabilmektedir. İstismar bildirimi yapıldıktan sonra çocukların yaşadıkları ruhsal dinamiklerin ruh sağlığı profesyonelleri tarafından bilinmesi çocukları korumak adına önemlidir. İstismar olgularının tedavisinde bilişsel davranışçı terapiler ve ilaç tedavileri yaygın olarak kullanılmaktadır. Ancak bazı olgularda; mağdurların ortamdan uzaklaştırılması, eğitim hayatlarına devam edebilmelerinin sağlanması, güvenli bir alanda profesyonel kişiler tarafından tedavi yöntemlerinin uygulanması gerekmektedir. Bu amaçla dünyanın birçok ülkesinde Rezidental Tedavi merkezleri kurulmuştur. Türkiye'de ise ilk rezidental kurumu olan "Oğuz Kağan Köksal Sosyal Bakım ve Rehabilitasyon Merkezi" Adana ilinde kurulmuştur. Bu yazıda çocuk istismarının tarihsel boyutu, tanımı, ruhsal dinamikleri, yol açtığı ruhsal bozukluklar, tedavi yaklaşımları ve rezidental tedavi merkezleri gözden geçirilmeye çalışılmıştır.Anahtar sözcükler: Rezidental tedavi, çocuk İstismarı, travma sonrası stres bozukluğu. AbstractEvery year millions of reports are being held and cases regarding those reports in courts are carrying on about abusement and omission against children. Abusement against children has been seen throughout of the history. Significant and permanent impacts can occur upon child abusement and neglect on victim children. It is important to know the psychological dynamics which have been lived by the children by the mental health professionalsto protect the children after the abusement report has been written. Cognitive behavioral therapy and medications are being used commonly in the treatment of abusement cases. However in some cases it is necessary to send away the victims from environment, enable them to continue their education life, make sure that they are treated by the professional individuals in safe area. For this end there are many Residential Treatment Centers around the world. "Oğuz Kağan Köksal Social Care and Rehabilitation Center " was established in Adana as the first Residential Treatment Center in Turkey. In this report the historical dimensions of the child abusement, the definition of it, its psychological dynamics, the psychological disorders caused by it, treatment approaches and residential treatment centers have been reviewed.

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Family history of suicidal behavior and early traumatic experiences: Additive effect on suicidality and course of bipolar illness?

Abstract: Background-Bipolar Disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects.

Cited by 101 publications

References 42 publications

A qualitative investigation into the relationships between social factors and suicidal thoughts and acts experienced by people with a bipolar disorder diagnosis

A qualitative investigation into the relationships between social factors and suicidal thoughts and acts experienced by people with a bipolar disorder diagnosis

Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study

Residential Treatment Centers for Child Abuse

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