Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis

Díaz-Castro, Lina; Hoffman, Kurt L.; Cabello-Rangel, Héctor; Arredondo, Armando; Herrera-Estrella, Miguel

doi:10.1177/00469580211060797

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…In the present study, as in a previous analysis of the same patient population [ 33 ], there were notable differences between male and female patients with regard to several measures (for a review of gender differences in SCH see Ochoa et al 2012 [ 34 ]). Notably, men were twice as likely than women to report having dropped out of school at the secondary or high school levels.…”

Section: Discussionsupporting

confidence: 75%

Analysis of Educational Attainment in a Mexican Psychiatric Patient Population with Bipolar or Psychotic Disorders

2023

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Schizophrenia has been associated with premorbid poor educational performance and low educational attainment (EA). However, some studies have found positive associations between psychotic disorders and excellent scholastic performance. In the present study, we examined the association between EA and several clinical and nonclinical characteristics in psychiatric patients diagnosed with psychotic or bipolar disorders. Data were obtained from the files of 1132 patients who entered a major Mexico City psychiatric hospital during the years 2009–2010 for the treatment of psychotic symptoms and who were subsequently diagnosed with schizophrenia, bipolar, schizoaffective, or another psychotic disorder. Chi-squared tests, t-tests, and Cox regression analysis were applied to explore associations between EA and factors including gender, familial history of mental illness, premorbid personality characteristics, age of symptom onset, diagnosis, civil status, and current employment. Family history of mental illness decreased the hazard of having lower EA (B = −0.137, p = 0.025, ExpB = 0.872, 95% CI = 0.774–0.983), while a schizophrenia diagnosis independently increased it (B = 0.201, p = 0.004, ExpB = 1.223, 95% CI = 1.068–1.401). In male patients (but not in females), family history of mental illness was significantly associated with higher EA, while in female patients, premorbid schizoid-like personality characteristics were associated with lower EA. For both genders, lower EA was associated with having more children and being employed in manual labor, while higher EA was associated with professional employment. Conclusions: Compared with bipolar disorder, a schizophrenia diagnosis is associated with lower EA; however, familial history of mental illness and premorbid schizoid-like characteristics independently favor higher and lower EA in males and females, respectively. Since lower EA is generally associated with a lower economic status, special preventative attention should be given to students at high risk for schizophrenia, particularly those displaying a schizoid-like personality.

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Section: Discussionsupporting

confidence: 75%

Analysis of Educational Attainment in a Mexican Psychiatric Patient Population with Bipolar or Psychotic Disorders

2023

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“…This finding was also obtained in another review study investigating the neuropsychiatric side effects of chloroquine (63). The results of the current literature review showed that most patients had no family or personal history of psychiatric disorders, although the risk of psychiatric events may be influenced by familial risk (64). It can be a practical warning notice for healthcare providers that expect psychiatric manifestations following chloroquine therapy in patients with no previous history.…”

Section: Discussionsupporting

confidence: 65%

The Ignored Psychiatric Aspect of Chloroquine in the COVID-19 Outbreak Period: A Narrative Review Study

Kamali

Azizi

Elyasi

2023

Iran J Psychiatry Behav Sci

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Context: Several studies have shown that chloroquine can effectively diminish the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As such, other studies have also supported this statement, but the psychiatric side effects of chloroquine have not been taken into account. So, the current study aimed to briefly review and discuss the safety of chloroquine. Methods: A narrative literature search on databases was carried out on studies without time limitations. A combination of the two main keywords of “Chloroquine” and “Psychiatric Side Effects” was used to search databases. A manual search was performed to find the relevant articles, and finally, 15 studies were reviewed. Data were shown in the table and then summarized by narrative synthesis. Results: The literature review revealed the pharmaceutical characteristics of chloroquine, the safety of chloroquine, and the management of chloroquine's side effects. Also, the studies showed that chloroquine had psychiatric symptoms varying from insomnia to catatonia, toxic psychosis, and suicidal attempts, as well as behavioral manifestations, including most frequently extreme irritability, restlessness, abusiveness, distractibility, pressured speech, flight of ideas, grandiosity delusion, and auditory and visual hallucinations. Conclusions: Given the probability of a wide range of possible psychiatric symptoms following chloroquine, physicians should cautiously prescribe antiviral agents, and healthcare workers should also notice any psychiatric symptoms after administrating the chloroquine.

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“…Furthermore, this gap in mortality rates is continuing to widen ( Tanskanen et al, 2018 ). Environmental factors, such as social isolation, childhood trauma, urban living, and ethnicity, are considered to be among the multifactorial causes of SCZ ( Diaz-Castro et al, 2021 ; Srivastava et al, 2021 ). SCZ may have its origins in utero , with obstetric potential risk factors including complications such as low birth weight, gestational diabetes, bleeding, asphyxia, and emergency caesarean section.…”

Section: Introductionmentioning

confidence: 99%

Deviant spontaneous neural activity as a potential early-response predictor for therapeutic interventions in patients with schizophrenia

Jing,

Zhang,

Yan

et al. 2023

Front. Neurosci.

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ObjectivePrevious studies have established significant differences in the neuroimaging characteristics between healthy controls (HCs) and patients with schizophrenia (SCZ). However, the relationship between homotopic connectivity and clinical features in patients with SCZ is not yet fully understood. Furthermore, there are currently no established neuroimaging biomarkers available for the diagnosis of SCZ or for predicting early treatment response. The aim of this study is to investigate the association between regional homogeneity and specific clinical features in SCZ patients.MethodsWe conducted a longitudinal investigation involving 56 patients with SCZ and 51 HCs. The SCZ patients underwent a 3-month antipsychotic treatment. Resting-state functional magnetic resonance imaging (fMRI), regional homogeneity (ReHo), support vector machine (SVM), and support vector regression (SVR) were used for data acquisition and analysis.ResultsIn comparison to HCs, individuals with SCZ demonstrated reduced ReHo values in the right postcentral/precentral gyrus, left postcentral/inferior parietal gyrus, left middle/inferior occipital gyrus, and right middle temporal/inferior occipital gyrus, and increased ReHo values in the right putamen. It is noteworthy that there was decreased ReHo values in the right inferior parietal gyrus after treatment compared to baseline data.ConclusionThe observed decrease in ReHo values in the sensorimotor network and increase in ReHo values in the right putamen may represent distinctive neurobiological characteristics of patients with SCZ, as well as a potential neuroimaging biomarker for distinguishing between patients with SCZ and HCs. Furthermore, ReHo values in the sensorimotor network and right putamen may serve as predictive indicators for early treatment response in patients with SCZ.

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Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis

Cited by 4 publications

References 44 publications

Analysis of Educational Attainment in a Mexican Psychiatric Patient Population with Bipolar or Psychotic Disorders

Analysis of Educational Attainment in a Mexican Psychiatric Patient Population with Bipolar or Psychotic Disorders

The Ignored Psychiatric Aspect of Chloroquine in the COVID-19 Outbreak Period: A Narrative Review Study

Deviant spontaneous neural activity as a potential early-response predictor for therapeutic interventions in patients with schizophrenia

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