Family history of myocardial infarction as a strong independent predictor of in-stent restenosis in the era of drug eluting stents

Liu, Ye; Xu, Changlu; Fu, Peng; Chen, Jie; Cao, Qian; Yang, Tiangui; Niu, Tiesheng

doi:10.1016/j.ijcard.2014.10.082

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Percutaneous coronary intervention (PCI) has become the major therapeutic procedure for coronary artery disease (CAD) in recent 30 years. [ 1 2 ] However, several large-scale clinical trials had confirmed that even in the drug-eluting stent (DES) era, the occurrence rate of in-stent restenosis (ISR) after coronary stent implantation still ranged from 3% to 20%. [ 3 ] Especially among patients with diabetes mellitus (DM), the risk of developing ISR after PCI appeared to be 2–4 times higher compared with nondiabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Elevated Levels of Very Low-density Lipoprotein Cholesterol Independently Associated with In-stent Restenosis in Diabetic Patients after Drug-eluting Stent Implantation

Qin

Zheng

Zeng

et al. 2017

Chinese Medical Journal

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Background:High rate of in-stent restenosis (ISR) remained an unsolved clinical problem in clinical practice, especially among patients with diabetes mellitus (DM). Diabetic patients often had hypertriglyceridemia with elevated levels of very low-density lipoprotein cholesterol (VLDL-C). Increasing evidence suggested that VLDL-C was known as a significant risk factor for atherosclerosis and had been recommended as a treatment target by current dyslipidemia guidelines. However, the role of VLDL-C in the occurrence and development of ISR in coronary artery disease (CAD) patients with DM had not been studied. The aim of this study was to evaluate the association between the elevated levels of VLDL-C and the risk of ISR in CAD patients with DM.Methods:A total of 1390 diabetic patients, who underwent coronary drug-eluting stent (DES) implantation at Beijing Anzhen Hospital and followed up by angiography within 6–24 months, were consecutively enrolled. Patients’ demographic and clinical characteristics, including age, gender, CAD risk factors, family history, life style, medical history, and coronary angiographic information, were collected carefully at baseline percutaneous coronary intervention and follow-up angiography. Multivariate Cox's proportional hazards regression modeling using the step-wise method (entry, 0.05; removal, 0.05) was used to determine the independent risk associated with ISR in diabetic patients.Results:Finally, 1206 of patients were included in this study. ISR occurred in 132/1206 diabetic patients (10.9%) by follow-up angiography. Patients with ISR had elevated median serum VLDL-C levels compared with those without ISR (0.65 mmol/L vs. 0.52 mmol/L, P = 0.030). The multivariate regression analysis showed that VLDL-C was significantly associated with the risk of ISR in diabetic CAD patients (hazard ratio [HR] = 1.15, 95% confidence interval [CI]: 1.03–1.29, P = 0.017). The HR for the risk of ISR associated with VLDL-C level ≥0.52 mmol/L was 3.01 (95% CI: 1.24–7.34, P = 0.015).Conclusion:The elevated level of serum VLDL-C was a significant and independent risk factor for ISR in diabetic CAD patients after coronary DES implantation.

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Section: Introductionmentioning

confidence: 99%

Elevated Levels of Very Low-density Lipoprotein Cholesterol Independently Associated with In-stent Restenosis in Diabetic Patients after Drug-eluting Stent Implantation

Qin

Zheng

Zeng

et al. 2017

Chinese Medical Journal

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High-risk Plaque and Calcification Detected by Coronary CT Angiography to Predict Future Cardiovascular Events After Percutaneous Coronary Intervention

et al. 2018

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Effect and significance of hyperlipoproteinemia on stent thrombosis in patients with implanted drug-eluting stents: The 5-year follow up study

Stojanović

Cupic

2022

The American Journal of the Medical Sciences

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show abstract

Family history of myocardial infarction as a strong independent predictor of in-stent restenosis in the era of drug eluting stents

Cited by 3 publications

References 10 publications

Elevated Levels of Very Low-density Lipoprotein Cholesterol Independently Associated with In-stent Restenosis in Diabetic Patients after Drug-eluting Stent Implantation

Elevated Levels of Very Low-density Lipoprotein Cholesterol Independently Associated with In-stent Restenosis in Diabetic Patients after Drug-eluting Stent Implantation

High-risk Plaque and Calcification Detected by Coronary CT Angiography to Predict Future Cardiovascular Events After Percutaneous Coronary Intervention

Effect and significance of hyperlipoproteinemia on stent thrombosis in patients with implanted drug-eluting stents: The 5-year follow up study

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