“…The presence of familial metabolic risk factors is known to predict future cardiovascular events in the offspring. 17,18 However, the intrafamilial aggregation of flowmediated vascular dilation has been shown to be significantly higher in father-offsprings than in mother-offsprings. 16 It is known that high-density lipoprotein-cholesterol levels are a determinant of flow-mediated vascular dilation and are associated with genetic variation in the Y chromosome.…”
Section: Discussionmentioning
confidence: 99%
“…16 Indeed, the presence of familial metabolic risk factors is known to predict future cardiovascular events in the offspring. 17,18 It is well known that increased cIMT is an independent risk marker for coronary artery disease and stroke, becoming a sensitive subclinical atherosclerosis marker. 19 Given the associations found in adults and in children with iron overload, we hypothesized that serum ferritin levels could be linked to cIMT in children from the general population.…”
Objective-Body iron status has been linked to atherosclerosis in adults. The purposes of our study were to determine (1) the association between circulating ferritin levels and carotid intima-media thickness (cIMT) in a cohort of apparently healthy children and (2) the association between cIMT and parental ferritin levels. Approach and Results-Circulating ferritin levels (microparticle enzyme immunoassay), metabolic parameters, and cIMT (ultrasonography) were analyzed cross-sectionally in a cohort of 692 healthy white children with a mean age of 8±2 years (52% girls and 48% boys). In consecutive 123 children from the cross-sectional sample, the same serum assessments were also performed at baseline in their parents, and the cIMT was repeated after 3 years of follow-up in the children at a mean age of 11±2 years (53% girls and 47% boys). Weak but significant positive associations were evident between children's circulating ferritin levels and cIMT (r=0.123; P=0.001) and with the change in cIMT 3 years later a tendency was also observed (r=0.185; P=0.048). In multiple regression analyses, circulating ferritin levels contributed independently to cIMT variance (β=0.090; P=0.026; R 2 =10%) and cIMT change variance (β=0.216; P=0.019; R 2 = 3.4%) after controlling for body mass index, high-sensitivity C-reactive protein, age, sex, and low-density lipoprotein-cholesterol levels. This association was, however, remarkably significant (β=0.509; P=0.001; R 2 = 20.4%) in children whose fathers had ferritin levels above the median value (122.5 ng/mL).The latter association remained significant after correction for multiple testing. Maternal's ferritin levels showed no interaction in this association.
Conclusions-These
“…The presence of familial metabolic risk factors is known to predict future cardiovascular events in the offspring. 17,18 However, the intrafamilial aggregation of flowmediated vascular dilation has been shown to be significantly higher in father-offsprings than in mother-offsprings. 16 It is known that high-density lipoprotein-cholesterol levels are a determinant of flow-mediated vascular dilation and are associated with genetic variation in the Y chromosome.…”
Section: Discussionmentioning
confidence: 99%
“…16 Indeed, the presence of familial metabolic risk factors is known to predict future cardiovascular events in the offspring. 17,18 It is well known that increased cIMT is an independent risk marker for coronary artery disease and stroke, becoming a sensitive subclinical atherosclerosis marker. 19 Given the associations found in adults and in children with iron overload, we hypothesized that serum ferritin levels could be linked to cIMT in children from the general population.…”
Objective-Body iron status has been linked to atherosclerosis in adults. The purposes of our study were to determine (1) the association between circulating ferritin levels and carotid intima-media thickness (cIMT) in a cohort of apparently healthy children and (2) the association between cIMT and parental ferritin levels. Approach and Results-Circulating ferritin levels (microparticle enzyme immunoassay), metabolic parameters, and cIMT (ultrasonography) were analyzed cross-sectionally in a cohort of 692 healthy white children with a mean age of 8±2 years (52% girls and 48% boys). In consecutive 123 children from the cross-sectional sample, the same serum assessments were also performed at baseline in their parents, and the cIMT was repeated after 3 years of follow-up in the children at a mean age of 11±2 years (53% girls and 47% boys). Weak but significant positive associations were evident between children's circulating ferritin levels and cIMT (r=0.123; P=0.001) and with the change in cIMT 3 years later a tendency was also observed (r=0.185; P=0.048). In multiple regression analyses, circulating ferritin levels contributed independently to cIMT variance (β=0.090; P=0.026; R 2 =10%) and cIMT change variance (β=0.216; P=0.019; R 2 = 3.4%) after controlling for body mass index, high-sensitivity C-reactive protein, age, sex, and low-density lipoprotein-cholesterol levels. This association was, however, remarkably significant (β=0.509; P=0.001; R 2 = 20.4%) in children whose fathers had ferritin levels above the median value (122.5 ng/mL).The latter association remained significant after correction for multiple testing. Maternal's ferritin levels showed no interaction in this association.
Conclusions-These
“…Studies comparing carotid intima-media thickness and aortic stiffness in normotensive children of hypertensive parents with children of normotensive parents revealed that carotid intimamedia thickness increased in both adolescents and young adults. [24][25][26][27][28][29][30][41][42][43][44] Evelein et al 27 found that carotid intima-media thickness was higher in children older than 5 years of age compared to controls, an increase that may be observed as early as at the age of 5. Xiang et al 26 evaluated 206 children aged 16 years and older from 69 hypertensive families and demonstrated that carotid intima-media thickness was increased, an increase that correlated with both age and Arterial features in children of hypertensive parents A Yildirim et al genetic factors.…”
A significant correlation between hypertension history and high blood pressure has been observed with regard to age, race and gender. Investigating carotid intima-media thickness and aortic stiffness prior to the development of hypertension in children of hypertensive parents enabled us to evaluate these patients for subclinical atherosclerosis. We compared carotid intima-media thickness, aortic strain, distensibility, stiffness indices and elastic modulus in 67 normotensive children whose parents had a diagnosis of essential hypertension and 39 normotensive children with no parental history of hypertension. Although there were no significant differences between the two groups in terms of systolic blood pressure, diastolic blood pressure, average blood pressure and pulse pressure (P>0.05), systolic blood pressures were higher among patients 15 years and older in the study group. No significant differences were noted between the control and study groups regarding interventricular septal thickness, left-ventricular posterior wall thickness, left-ventricular systolic and diastolic diameter and aortic annulus diameter (P>0.05). The left atrium diameter was larger in the study group compared with that in the control group, mainly because of the values of the 15-year-old and older children (P=0.01). The mean, maximum and minimum values of carotid intima-media thickness were significantly different in the study group compared with the control group among all age groups (P<0.001, P<0.001, P=0.006, respectively). Aortic systolic and diastolic diameters were larger in normotensive children of hypertensive parents compared with the control group (P=0.014, P=0.001, respectively). Although there were no differences between the study and control groups regarding aortic strain, aortic distensibility, elastic modulus and stiffness indices (P>0.05), aortic distensibility was lower, and aortic stiffness indices were higher among children 15 years and older in the study group. An increase in the carotid intima-media thickness in all age groups and a decrease in aortic elastic properties in 15-year-old and older children of hypertensive parents may indicate subclinical atherosclerosis in these apparently healthy children.
“…Hypertension is the most important risk factor for SVD [49] . In patients with a family history of hypertension, the vasculature has already been damaged be- and SBP or DBP [50] .…”
Section: Other Risk Factors Asymmetric Dimethylargininementioning
Small vessel disease (SVD) is responsible for brain chronic circular disorder, and accounts for 20%-30% cases of ischemic stroke as well as cerebral hemorrhage, and to a great extent, encephalopathy. Binswanger's disease and multiple small strokes, which are common in older people, are also closely associated with SVD. These disorders often cause decline in cognition, vascular dementia, impairment in gait and balance, mood depression, and urinary incontinence, and often brings great social and economic burdens. SVD-related encephalopathy increases the incidences of fall, disability and death in elderly people. With the aging of the society, more attention should be paid to the importance of early diagnosis and prophylactic treatment of SVD. Here the clinical manifestations and pathophysiology of SVD are reviewed.
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