Family history in breast cancer in São Luís, Maranhão, Brazil

Abstract

BackgroundFamilial cancer includes some types of cancer aggregation without a well-defined inheritance pattern. Cancer genetics is an essential component of clinical practice in oncology. In Brazil, breast cancer is the leading cause of death in women. In Maranhão, studies on genetic predisposition are necessary to investigate the incidence and mortality rates. The aim of this study was to investigate familial cancer among relatives of women who died of breast cancer in São Luís, Brazil, constructing a pedigree to identify families with a hereditary predisposition, an important step in the early diagnosis of malignant tumors.MethodsThe city of São Luís is located on the Island of Maranhão, northeastern Brazil, with a population of 997,098 inhabitants mainly comprising blacks and mulattoes, including descendants of runaway slaves from the Amazon region itself. Data for pedigree construction were obtained from the records of 54 patients seen at the Aldenora Bello Institute of Oncology, São Luís, between 2000 and 2007, as well as by interview with relatives of the patients.ResultsThe mean patient age at diagnosis was 39.5 years. Most women were mulattoes (36/54, 66.6 %). A history of cancer was observed in 18 families, with 16 families possessing cases of cancer among first-degree relatives and five among second-degree relatives.ConclusionA concentration of cancer cases was found in families of patients diagnosed until the age of 40, a finding demonstrating the importance of a family history prior to genetic counseling.

Doenças Crônicas Não Transmissíveis: perfil da mortalidade no município de Natal/RN no período de 2000 a 2014

“…23,24 As causas de câncer são variadas, podendo ser externas ou internas ao organismo, estando ambas inter-relacionadas. As causas externas relacionam-se ao meio ambiente e aos hábitos ou costumes próprios de um ambiente social e cultural.…”

“…23 A prevalência do tabagismo em pessoas com 18 anos no Brasil reduziu de 34,8% em 1989 para 22,4% em 2003. Uma redução ainda maior para 17,2% (21,6% de homens e 13,1% de mulheres com 15 anos de idade ou mais) foi registrada até 2009.…”