Family history and socioeconomic factors as predictors of myocardial infarction, unstable angina and stroke in an Italian population

Vitullo, F; Marchioli, Roberto; Mascio, Rocco Di; Cavasinni, L; Pasquale, Antonio De; Tognoni, Gianni

doi:10.1007/bf00145504

Cited by 25 publications

(28 citation statements)

References 28 publications

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“…10,11,32,34 Two studies did report sex-of-parent effects for family history of MI in patients with MI, 23,24 but they were not population based, were restricted to younger age groups, and did not report sex-of-offspring/sex-ofparent interactions. One study attempted to determine sex-of-offspring/sex-of-parent interactions, 24 but it was a retrospective comparison of 2 separate single-sex cohorts in which data were collected by different methods.…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes

Banerjee

Silver

Heneghan

et al. 2009

Circ Cardiovasc Genet

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Background-Family history of premature myocardial infarction (MI) in first-degree relatives is a risk factor for MI and an indication for primary prevention. Although excess mother-to-daughter "transmission" occurs in ischemic stroke, no published studies have considered sex-of-parent/sex-of-proband interactions in the heritability of MI. Methods and Results-In a population-based study (Oxford Vascular Study) of all patients with acute coronary syndromes (ACS), irrespective of age, family history of all acute vascular events and related risk factors were analyzed by sex and age of both probands and first-degree relatives. Premature events were categorized as occurring at age Ͻ65 years. Of 835 probands with 1 or more ACS, 623 (420 men) had incident events and complete family history data. In probands with premature ACS, maternal history of both MI and of all vascular events were more common in female than male probands (odds ratio Greater emphasis should be placed on maternal than paternal history of MI, particularly in women aged Ͻ65 years.

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Section: Discussionmentioning

confidence: 99%

Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes

Banerjee

Silver

Heneghan

et al. 2009

Circ Cardiovasc Genet

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“…Two studies that investigated the influence of environmental factors other than smoking on family history of stroke as a risk factor for stroke found no significant association. 35,64 Tenʈ of 12 studies 56,59 investigating a possible interaction between family history of stroke and hypertension in patients found a significant association; 3 studies found an association with smoking, 35,44,52 3 found an association with diabetes mellitus, 37,44,52 4 found an association with the presence of ischemic heart disease or vascular disease, 31,37,46,52 and 1 found an association with the presence of hyperlipidemia. 42 Two studies found that family history of stroke was significantly related to a cluster of vascular risk factors.…”

Section: Case-control Studiesmentioning

confidence: 99%

“…Two case-control studies 46,64 and 1 prospective cohort study 26 reported the effect if both parents had been affected by stroke 26,64 or vascular disease. 46 The combined OR for a family history of stroke in the case-control studies increased significantly (Pϭ0.018) when they were analyzed separately for a family history in only 1 parent (OR, 1.08; 95% CI, 0.7 to 1.6; Pϭ0.77; heterogeneity Pϭ0.35) versus a family history of both parents (OR, 2.45; 95% CI, 1.4 to 4.2; Pϭ0.002; heterogeneity Pϭ0.…”

Section: Influence Of Number Of Affected Relativesmentioning

confidence: 99%

“…Five case-control studies 41,48,50,63,64 recruited only patients aged Ͻ70 years, 1 study recruited patients with stroke onset at Ͻ65 years, 60 1 study recruited patients with stroke onset at Ͻ50 years, 55 and 1 study reported family histories separately for patients aged Ͻ54 and Ն54 years. 68 The combined OR for these younger patient groups was nonsignificantly (Pϭ0.10) higher (OR, 1.93; 95% CI, 1.7 to 2.2; PϽ0.00001; heterogeneity Pϭ0.0001; 1240 patients; Figure 6) than the remainder (OR, 1.69; 95% CI, 1.6 to 1.8; PϽ0.00001; heterogeneity Pϭ0.00001).…”

Section: Influence Of Agementioning

confidence: 99%

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Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke

Floßmann

Schulz

Rothwell

2004

Stroke

340

251

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Background and Purpose-To design appropriate molecular genetic studies, we first need to understand the genetic epidemiology of stroke. We therefore performed a systematic review of the literature to assess the heritability of stroke according to methodological quality of studies and to determine any heterogeneity in findings between studies and possible publication bias. Methods-We searched for twin studies and studies of family history of stroke using bibliographic databases and by hand-searching reference lists and journals. Odds ratios (ORs) for family history as a risk factor for stroke were calculated within studies and combined by meta-analysis. Heterogeneity between studies, methodological quality of studies, and the influence of the age at which stroke occurred in both probands and relatives were assessed. Results-We identified 53 independent studies (3 twin, 33 case-control, and 17 cohort). Monozygotic twins were more likely to be concordant than dizygotic twins (OR, 1.65; 95% CI, 1.2 to 2.3; Pϭ0.003). A positive family history was a risk factor for stroke in both case-control (OR, 1.76; 95% CI, 1.7 to 1.9; PϽ0.00001) and cohort (OR, 1.30; 95% CI, 1.2 to 1.5; PϽ0.00001) studies. However, there was major heterogeneity between studies (cohort Pϭ0.0001; case-control PϽ0.00001), with much stronger associations in small studies and methodologically less rigorous studies. Moreover, studies that reported insufficient data to allow meta-analysis tended to have found weaker associations. Family history of stroke was more frequent in studies that were confined to probands or relatives aged Ͻ70 years. However, few studies considered the number of affected and unaffected relatives, only 2 studies considered stroke phenotypes in detail, and only 19 studies (38%) adjusted associations for intermediate phenotypes.No twin study, only 5 cohort studies (26%), and 20 case-control studies (61%) differentiated between ischemic and hemorrhagic stroke in the proband. Family history of stroke was more frequent in large-and small-vessel stroke than in cardioembolic stroke. There were very few data on the influence of family history on stroke severity and no data on stroke recovery. Conclusions-Twin studies suggest a small genetic contribution to stroke, but reliable interpretation of published family history studies is undermined by major heterogeneity, insufficient detail, and potential publication and reporting bias.More detailed large-scale genetic epidemiology is required.

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“…Otros estudios revisados no hacen referencia a AFP como tal sino que se refieren sin más a un historial familiar positivo de eventos cardiovasculares (18,19). En todos los casos no se 14 B. EBRÍ TORNÉ ET AL.…”

Section: Discussionunclassified

Diferencias en variables representativas de enfermedad o repercusión cardiovascular entre sujetos de alto riesgo cardiovascular con y sin antecedentes familiares de eventos cardiovasculares precoces

Torné

Verde

Suso

et al. 2006

An. Med. Interna (Madrid)

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INTRODUCCIÓNLos antecedentes familiares de eventos cardiovasculares precoces (AFP) no se consideran como un factor de riesgo introducido en las ecuaciones de riesgo cardiovascular. Otros factores [0212-7199 (2006) Resultados y discusión: Observamos un incremento significativo (p < 0,05) en el grupo con AFP del porcentaje de las siguientes variables: colesterol total > 250 mg/dl, HDL < 40 mg/dl, LDL > 130 mg/dl, HVI (hipertrofia ventricular izquierda), creatinina 1,2-2 mg/dl, retinopatía I-II, retinopatía grave, tabaquismo, proteinuria > 300 mg/dl, Insuficiencia renal y enfermedad vascular periférica. Este incremento significativo de las variables estudiadas se produce en varones de más de 55 años y en mujeres de más de 65 años; no obstante comienza a observarse este aumento del porcentaje de incidencia a partir de los 50 años en varones, con un máximo en ambos sexos tras los setenta. No se observan diferencias significativas respecto a sexo, IMC (índice de masa corporal) ateromatosis, cardiopatía isquémica y enfermedad cerebrovascular. Existe en general en ambos sexos un adelanto de tres años en el grupo de AFP en acudir a la consulta médica respecto al grupo que no posee AFP.Conclusiones: Los pacientes con AFP presentan mayor incidencia de ciertos factores de riesgo cardiovascular y de lesión de órgano diana. DIFFERENCES IN VARIABLES REPRESENTATIVE OF CARDIOVAS-CU-LAR DISEASE OR REPERCUSSION BETWEEN SUBJECTS WITH HIGH CARDIOVASCULAR RISK WITH AND WITHOUT ANY FAMILY HISTORY OF EARLY CARDIOVASCULAR EVENTSEste estudio fue premiado como la mejor comunicación MIR presentada al XXVI Congeso Nacional de la SEMERGEN, Granada 13 al 16 de Octubre de 2004.

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Family history and socioeconomic factors as predictors of myocardial infarction, unstable angina and stroke in an Italian population

Cited by 25 publications

References 28 publications

Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes

Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes

Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke

Diferencias en variables representativas de enfermedad o repercusión cardiovascular entre sujetos de alto riesgo cardiovascular con y sin antecedentes familiares de eventos cardiovasculares precoces

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