Family history and risk of miscarriage: A systematic review and meta‐analysis of observational studies

Woolner, Andrea; Nagdeve, Priti; Raja, Edwin Amalraj; Bhattacharya, Siladitya; Bhattacharya, Sohinee

doi:10.1111/aogs.13940

Cited by 17 publications

(10 citation statements)

References 38 publications

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“…A summary of epidemiological factors and their potential effects on the risk of pregnancy loss are shown in Table 3. [7][8][9][10] Aetiology A 2018 study 11 into RPL aetiology showed only 26% of the patients reviewed had an explained cause, with the rest not given an aetiology or a causative reason.…”

Section: Definition Of Recurrent Pregnancy Lossmentioning

confidence: 99%

Current management of recurrent pregnancy loss

Chester

Tirlapur

Jayaprakasan

2022

The Obstetric & Gynaecologis

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Key content Referral criteria to recurrent pregnancy loss (RPL) services vary, owing in part to a lack of consensus on the definition of RPL. Good quality evidence is limited, and controversies exist on recommendations for investigations and management of RPL. People with RPL will most likely achieve a live birth in their next pregnancy but should have an individualised approach that identifies and corrects any modifiable risk factors and offers appropriate psychological support. Learning objectives To look at the variations in definition and aetiology of RPL and use current evidence available for recommendations towards investigations and management of RPL. To be familiar with evidence‐based guidelines published by the Royal College of Obstetricians and Gynaecologists, the American Society for Reproductive Medicine and the European Society of Human Reproduction, as well as recently published data, which will help to improve clinical outcome utilising the interventions with proven efficacy. Ethical issues Differences in referral criteria and the controversies around RPL mean there can be considerable variation in how these patients are managed between services. The lack of good quality evidence can result in patients opting for management strategies with unproven efficacy.

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Section: Definition Of Recurrent Pregnancy Lossmentioning

confidence: 99%

Current management of recurrent pregnancy loss

Chester

Tirlapur

Jayaprakasan

2022

The Obstetric & Gynaecologis

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“…Moreover, an increased probability of the same karyotype pattern (recurrent normal or recurrent abnormal) in multiple consecutive abortions was found for RPL patients [ 32 , 33 , 34 ]. In addition, women who miscarry may be more likely to have a family history of miscarriage [ 35 ]. The significance of genetic factors in miscarriage was proven by the six-fold increase in RPL prevalence among first-degree relatives of idiopathic RPL patients in comparison with the general population [ 36 , 37 ].…”

Section: Genetic Causes Of Miscarriagementioning

confidence: 99%

Stem Cell-Based Trophoblast Models to Unravel the Genetic Causes of Human Miscarriages

Nikitina

Lebedev

2022

Cells

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Miscarriage affects approximately 15% of clinically recognized pregnancies, and 1–3% of couples experience pregnancy loss recurrently. Approximately 50–60% of miscarriages result from chromosomal abnormalities, whereas up to 60% of euploid recurrent abortions harbor variants in candidate genes. The growing number of detected genetic variants requires an investigation into their role in adverse pregnancy outcomes. Since placental defects are the main cause of first-trimester miscarriages, the purpose of this review is to provide a survey of state-of-the-art human in vitro trophoblast models that can be used for the functional assessment of specific abnormalities/variants implicated in pregnancy loss. Since 2018, when primary human trophoblast stem cells were first derived, there has been rapid growth in models of trophoblast lineage. It has been found that a proper balance between self-renewal and differentiation in trophoblast progenitors is crucial for the maintenance of pregnancy. Different responses to aneuploidy have been shown in human embryonic and extra-embryonic lineages. Stem cell-based models provide a powerful tool to explore the effect of a specific aneuploidy/variant on the fetus through placental development, which is important, from a clinical point of view, for deciding on the suitability of embryos for transfer after preimplantation genetic testing for aneuploidy.

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“…There should not be any language barrier while doing the physical and hysteroscopy examination and a proper language translator should be provided. Early bleeding might be associated with miscarriage therefore it is recommended to evaluate thoroughly for the gynecological history of the patients [67][68][69] . Statistic's analysis suggests that out of four women one faces miscarriage issues.…”

Section: Early Pregnancy Issuesmentioning

confidence: 99%

Role of Nurses in the Management of Common Gynecological Diseases: Recent Advances

Tuli

2021

JCNR

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In recent years the role of the specialist nurse with respect to gynecology and women’s health has gained significant importance. The advancement in the nursing practice has provided an insight to interact with patients to explore their history. Such hysteroscopy procedures may not only give a better feel to the patient but also explore the need for doctor treatment. The review updates about the ongoing advances in the field of nursing science to upgrade the life of patients with gynecological diseases. Evidence has suggested the promising role of nurses to motivate patients with improved health after the treatment. The present review will cover the various health issues of women including menstrual dysfunction, fertility, and management of pregnancy’s termination, uro-gynecological issues, and gyne-oncology, etc. The role of nurses during the above health issue will be discussed via various procedures. Therefore, the present review will conclude the significant importance of nurses in women’s health issues to sustain happiness and to strengthen the need to bring advances in the curriculum of nurses to full fill the requirement of medical staff.

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Family history and risk of miscarriage: A systematic review and meta‐analysis of observational studies

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 17 publications

References 38 publications

Current management of recurrent pregnancy loss

Current management of recurrent pregnancy loss

Stem Cell-Based Trophoblast Models to Unravel the Genetic Causes of Human Miscarriages

Role of Nurses in the Management of Common Gynecological Diseases: Recent Advances

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