Family Decision-Making About Organ Donation: A Systematic Review

Makmor, T; Abdillah, Nurul; Ms, NurulHuda; Noriza, Raja; Z, Roza Hazli

doi:10.22452/jummec.vol18no1.1

Cited by 5 publications

(1 citation statement)

References 15 publications

(14 reference statements)

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“…Intensive Care Med 2019;45:331-42.1 About Organ Donation: A Systematic Review. JUMMEC 2015;18:1-4 3. Ralph A, Chapman JR, Gillis J, Craig JC, Butow P, Howard K, et al Family Perspectives on Deceased Organ Donation: Thematic Synthesis of Qualitative Studies.…”

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confidence: 99%

Changing the method of consent to increase the numbers of cadaveric donors in Saudi Arabia: the autonomy paradox

2022

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Background: In Saudi Arabia, the gap between the demand and availability of organs persists, with a total of 13,731 patients who remain on the waiting list in 2019. Family refusal is a major obstacle limiting donation since their consent must be obtained prior to the retrieval of organs. The cause of family refusal is mainly due to the unknown wishes of their loved one to become a donor. This analysis aimed to compare three systems of obtaining consent in terms of effectiveness, respect for personal autonomy, and the cultural role of families in Saudi Arabia to ensure feasibility and effectiveness in increasing the number of donors. Policy alternatives and implications: The consent systems include opt-in (explicit consent), opt-out (presumed consent), and mandated choice systems. The mandated choice policy might be the optimal solution to investigate since it could balance the respect for individual autonomy and the cultural role of families in Saudi Arabia. Conclusions and recommendations: Mandated choice ensures the respect of personal autonomy while influencing the next of kin's decision to donate the organs. Additionally, a recommendation to decision makers is to utilize the Tawakkalna app to send alerts to the next of kin when a user registers as a donor with the user's consent. Moreover, more research should be dedicated to investigating the Saudi public's current culture and perceptions of organ donation to ensure feasibility.

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confidence: 99%

Changing the method of consent to increase the numbers of cadaveric donors in Saudi Arabia: the autonomy paradox

2022

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Exploring Stem Cells and Inflammation in Tendon Repair and Regeneration

Vinhas

Rodrigues

Gomes

2018

Advances in Experimental Medicine and Biology

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Tendon injuries are frequent and are responsible for substantial morbidity both in sports and in the workplace. Despite the endogenous mechanisms of tendon repair and regeneration, tendon healing upon injury is slow and often insufficient to restore complete biomechanics functionality.Inflammation has a pivotal role in tendon healing and failed healing responses contribute to the progression of tendinopathies. However, the molecular and cellular mechanisms involved are poorly understood requiring further insights.During inflammation, bioactive molecules such as cytokines secreted locally at the injury site, influence resident stem cells that contribute as modulatory agents over the niche towards homeostasis, holding great promise as therapeutic agents for tendon pathological conditions associated to unresolved inflammation and failed healing.This review overviews the role of cytokines and resident cells, focusing on the participation of tendon stem cell population in inflammation and tendon healing upon injury and their potential action in resolution of pathological conditions.

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