Family and twin studies in inflammatory bowel disease

Halme, Leena; Paavola–Sakki, Paulina; Turunen, Ulla; Lappalainen, Maarit; Färkkilä, M.; Kontula, Kimmo

doi:10.3748/wjg.v12.i23.3668

Cited by 254 publications

(184 citation statements)

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“…These four haplotypes have a combined Overview of GWA study, finemapping, and replication studies in regions on chromosomes 1p31. 3 p-values P < 10 -6…”

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confidence: 97%

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Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

Raelson

Little

Ruether

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

203

119

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Genome-wide association (GWA) studies offer a powerful unbiased method for the identification of multiple susceptibility genes for complex diseases. Here we report the results of a GWA study for Crohn's disease (CD) using family trios from the Quebec Founder Population (QFP). Haplotype-based association analyses identified multiple regions associated with the disease that met the criteria for genome-wide significance, with many containing a gene whose function appears relevant to CD. A proportion of these were replicated in two independent German Caucasian samples, including the established CD loci NOD2 and IBD5. The recently described IL23R locus was also identified and replicated. For this region, multiple individuals with all major haplotypes in the QFP were sequenced and extensive fine mapping performed to identify risk and protective alleles. Several additional loci, including a region on 3p21 containing several plausible candidate genes, a region near JAKMIP1 on 4p16.1, and two larger regions on chromosome 17 were replicated. Together with previously published loci, the spectrum of CD genes identified to date involves biochemical networks that affect epithelial defense mechanisms, innate and adaptive immune response, and the repair or remodeling of tissue.haplotype ͉ complex disease ͉ IL23R C rohn's disease (CD) is a chronic inflammatory bowel disease characterized by transmural inflammatory lesions that can affect the entire gastrointestinal tract (1). The lifetime prevalence is 0.5-1% in Caucasian populations (2) and reflects the combined effects of genetic predisposition and environmental factors (3). Genetic linkage and candidate gene approaches (4-14) have contributed to the elucidation of loci influencing genetic susceptibility to CD. More recently, genome-wide association (GWA) studies (15-21) have provided further insight into the molecular pathogenesis of the disease. The top candidate genes or loci that consistently replicate include NOD2, IL23R, ATG16L1, the IBD5 region on chromosome 5q31, and a region on 5p13.1 near the PTGER4 gene. The nature of these genes suggests that the major genetic risk factors for CD are involved in the innate immune response and destruction of intracellular bacteria.It is now clear that GWA studies provide a powerful and robust new tool for the identification of the multiple susceptibility alleles involved in complex diseases. Importantly, these types of studies have the ability to identify genes that impart only moderate increases in risk (21,22). However, most studies performed to date have identified only a few top signals, and the validation of true association among signals with lower statistical significance remains a challenge. In addition, most of the GWA studies to date have been performed by using general populations, for which very large sample sizes are required for success. They have also largely relied on single-marker analysis, with genome-wide haplotype-based association analyses receiving little attention.In early 2004, we conducted a GWA study for CD...

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“…These four haplotypes have a combined Overview of GWA study, finemapping, and replication studies in regions on chromosomes 1p31. 3 p-values P < 10 -6…”

mentioning

confidence: 97%

“…The lifetime prevalence is 0.5-1% in Caucasian populations (2) and reflects the combined effects of genetic predisposition and environmental factors (3). Genetic linkage and candidate gene approaches (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) have contributed to the elucidation of loci influencing genetic susceptibility to CD.…”

mentioning

confidence: 99%

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

Raelson

Little

Ruether

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

203

119

View full text Add to dashboard Cite

show abstract

“…Up to 5-10% of affected individuals have at least one first-degree family member with IBD with the relative M-cell risk to siblings ranging from 5-35 for CD and 10-15 for UC, suggesting that positive family history is more common in CD patients than in UC patients. 11,12 This notion was confirmed in studies of twins and those persons having a twin with IBD had the highest risk of developing IBD in comparison to the general population. 12,13 In monozygotic twins, the concordance rate for CD is reported to range between 40-60% compared to 4-12% in dizygotic twins, which is almost comparable to all siblings.…”

mentioning

confidence: 82%

“…11,12 This notion was confirmed in studies of twins and those persons having a twin with IBD had the highest risk of developing IBD in comparison to the general population. 12,13 In monozygotic twins, the concordance rate for CD is reported to range between 40-60% compared to 4-12% in dizygotic twins, which is almost comparable to all siblings. 11,12,14 The concordance rate for UC is less frequent in monozygotic twins as well as in dizygotic twins and ranges from 6-17% and 0-5% respectively.…”

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confidence: 82%

Role of defective autophagia and the intestinal flora in Crohn disease

et al. 2010

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“…Mais comment la « connectique » qui relie l'organe sensoriel au premier relais cérébral peut-elle s'établir si précocement et en même temps si pré-cisément ? Récemment, l'équipe dirigée par H. Sakano de l'université de Tokyo vient de répondre à cette question [1].…”

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