Families with non-Hodgkin lymphoma and plasma cell dyscrasias in their pedigrees
Peter H Wiernik,
Janice P Dutcher
Abstract:Although reports of familial clustering of hematologic malignancies have appeared for decades, the cause(s) of this uncommon occurrence is still not completely understood. Most modern investigations, however, support a genetic rather than an environmental exposure as a cause of this observation. Most pedigrees of families with familial hematologic malignancies demonstrate age of onset anticipation, with the disease diagnosed at an earlier age in successive generations. The cause of this phenomenon is clear in … Show more
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