Families at High and Low Risk for Depression

Weissman, Myrna M.; Wickramaratne, Priya; Nomura, Yoko; Warner, Virginia; Verdeli, Helen; Pilowsky, Daniel J.; Grillon, Christian; Bruder, Gerard E.

doi:10.1001/archpsyc.62.1.29

Cited by 396 publications

(360 citation statements)

References 58 publications

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“…This is especially so given that paternal depression and maternal antisocial behavior were not assessed and may have contributed in meaningful ways to the intergenerational transmission of risk. Furthermore, a multigenerational assessment of family history may be valuable as recent research has demonstrated moderating effects of grandparent psychopathology on grandchild symptom presentation (Weissman et al, 2005). However, missing data on family members beyond the parental generation presented an insurmountable challenge in the present study.…”

Section: Discussionmentioning

confidence: 92%

“…Yet symptom severity may be additionally informative, indicating the degree of genetic and/ or environmental loading. A recent study of depression across three generations of families indicated that illness severity, as measured by impairment, conferred greater risk of transmission to later generations (Weissman et al, 2005). Functional impairment increases incrementally with symptom severity (Judd et al, 2005).…”

mentioning

confidence: 99%

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Patterns of Psychopathology in the Families of Children with Conduct Problems, Depression, and both Psychiatric Conditions

Kopp

Beauchaine

2007

J Abnorm Child Psychol

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Comorbid conduct problems (CPs) and depression are observed far more often than expected by chance, which is perplexing given minimal symptom overlap. In this study, relations between parental psychopathology and children's diagnostic status were evaluated to test competing theories of comorbidity. Participants included 180 families with an 8-12-year-old child diagnosed with CPs, depression, both conditions, or neither condition. Although no single theory of comorbidity was supported fully, evidence suggested that CPs and depression may be inherited separately. Paternal antisocial characteristics and maternal depression provided independent prediction of both child depression and CPs. However, paternal antisocial behavior moderated the effect of maternal depression on CPs. For children with antisocial fathers, CPs were observed regardless of maternal depression levels. In contrast, a strong relation was observed between CPs and maternal depression for children without antisocial fathers.

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Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Patterns of Psychopathology in the Families of Children with Conduct Problems, Depression, and both Psychiatric Conditions

Kopp

Beauchaine

2007

J Abnorm Child Psychol

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“…Complementary to the findings of studies where offspring are the affected proband, investigations of depressed parents and grandparents have also found increased risk of anxiety (Lieb et al 2002a ;Weissman et al 2005), depression and substance disorders in offspring (e.g. Lieb et al 2002a).…”

Section: Familialitymentioning

confidence: 91%

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

et al. 2009

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"Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11." Psychological Medicine.39,12. 2043-2059. http://digitalcommons.wustl.edu/open_access_pubs/3923Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11Paper 5 of 7 of the thematic section : ' A proposal for a meta-structure for DSM-V and ICD-11 ' Background. The extant major psychiatric classifications DSM-IV, and ICD-10, are atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis would be greatly enhanced by an understanding of risk factors and clinical manifestations. In an effort to group mental disorders on the basis of aetiology, five clusters have been proposed. This paper considers the validity of the fourth cluster, emotional disorders, within that proposal.Method. We reviewed the literature in relation to 11 validating criteria proposed by a Study Group of the DSM-V Task Force, as applied to the cluster of emotional disorders.Results. An emotional cluster of disorders identified using the 11 validators is feasible. Negative affectivity is the defining feature of the emotional cluster. Although there are differences between disorders in the remaining validating criteria, there are similarities that support the feasibility of an emotional cluster. Strong intra-cluster co-morbidity may reflect the action of common risk factors and also shared higher-order symptom dimensions in these emotional disorders.Conclusion. Emotional disorders meet many of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster.

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“…10 Different types of investigation, such as adoption, twins or high-risk studies, corroborate the pivotal role of the familial component in the etiology of major depression, probably through gene-environment interactions. 11 As for the adult population, it is believed that the incidence and recurrence of depressive episodes can be mediated or moderated by stress factors such as losses, neglect or abuse, conflicts, and frustrations.…”

Section: Epidemiologymentioning

confidence: 98%

Mood disorders in childhood and adolescence

Rocha

Zeni

Caetano

et al. 2013

Rev. Bras. Psiquiatr.

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The identification and treatment of mood disorders in children and adolescents has grown over the last decades. Major depression is one of the most common and debilitating disorders worldwide, imposing a massive burden to the youth population. Bipolar disorder is being increasingly recognized as having its roots early in life, and its presentation during childhood and adolescence has been submitted to extensive research. This review aims to highlight clinical aspects of the current knowledge on mood disorders in the pediatric population, presenting updated information on epidemiology, diagnostic procedures, and management strategies. Limitations of available evidence and future directions of research in the field are also discussed.

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Families at High and Low Risk for Depression

Cited by 396 publications

References 58 publications

Patterns of Psychopathology in the Families of Children with Conduct Problems, Depression, and both Psychiatric Conditions

Patterns of Psychopathology in the Families of Children with Conduct Problems, Depression, and both Psychiatric Conditions

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

Mood disorders in childhood and adolescence

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