Familial syringoma. Case history and application of monoclonal anti-eccrine gland antibodies

Hashimoto, Ken; Blum, David M.; Fukaya, Takeshi; Eto, Hikaru

doi:10.1001/archderm.121.6.756

Cited by 33 publications

(17 citation statements)

References 6 publications

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“…[1234] Recently, lower acrosyringium origin or the transitional portion between the acrosyringium and dermal duct have been also suggested as origins. [56] Syringoma typically appears around puberty and the women are most commonly affected.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, they appear as multiple, small, firm, skin-colored or slightly yellow soft papules, 1-3 mm in diameter, symmetrically distributed and usually asymptomatic. [1234] Eruptive syringoma is a rare variant that typically develops on the face, anterior surfaces of the neck, chest, abdomen, upper extremities and genitalia. Most studies emphasize that the diagnosis of syringoma, particularly eruptive syringoma, usually was not suspected clinically and the definitive diagnosis is made by histological examination.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous syringoma: A clinicopathologic study of 34 new cases and review of the literature

Ghanadan

Khosravi

2013

Indian J Dermatol

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Background:Syringoma is a benign adnexal tumor derived from intraepidermal eccrine duct.Aim:The aim of the study is to report the experience concerning syringoma by reviewing the clinical and histopathologic features of a series of 34 histologically diagnosed syringoma patients observed over a period of six years.Materials and Methods:Thirty-four patients were sorted into two groups, localized and generalized syringoma, according to the Friedman and Butler classification. Different histopathologic findings were recorded in specially designed questionnaires for further analysis.Results:Ninety-seven percent of the patients were females with the mean age of 27.6 years. The mean duration of the lesions before the presentations was six years. The diagnosis of syringoma was only considered in 23 patients (67.6%) and was the initial diagnosis in only 13 (38.2%) patients. All histological findings were seen more common in our cases. in comparison to the documented cases in the literature. Clear cell change of epithelial eccrine cells was 85.2% and there was no difference in the histopathological findings in the two groups. Our patients with generalized syringoma (GS) had a considerable lower age of onset than the ones with localized syringoma (LS) (P = 0.027).Conclusion:Our patients with generalized syringoma were younger than the ones with localized syringoma. Distribution of the generalized syringoma was mainly in the chest and neck followed by the forearms whereas localized syringoma was mostly confined to the face, axilla and genitalia. There were also some conditions associated with our cases including sarcoidosis, calcinosis cutis and basal cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cutaneous syringoma: A clinicopathologic study of 34 new cases and review of the literature

Ghanadan

Khosravi

2013

Indian J Dermatol

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“…13 There have been many reports of familial multiple syringomas to date, including cases with the co-occurrence of the palpebral and eruptive types. 1,[14][15][16] A search of the literature shows that familial multiple syringomas is a rare disorder with possible autosomal dominant inheritance. Hereditary cases of concurrent palpebral and eruptive syringomas have also been reported 14 and it has been suggested that these are disorders within the same clinical spectrum.…”

Section: Discussionmentioning

confidence: 99%

“…1,[14][15][16] A search of the literature shows that familial multiple syringomas is a rare disorder with possible autosomal dominant inheritance. Hereditary cases of concurrent palpebral and eruptive syringomas have also been reported 14 and it has been suggested that these are disorders within the same clinical spectrum. A review of 29 cases of multiple syringomas found that six cases involved family members who also suffered from eruptive syringomas.…”

Section: Discussionmentioning

confidence: 99%

Autosomal dominant multiple syringomas linked to chromosome 16q22

Lee

2010

British Journal of Dermatology

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“…These include bilateral acral sy¬ ringomas,45 a unilateral nevoidal pattern of syrin¬ gomas,6 localized vulvar™ and penile syringomas,' and syringomas of the scalp associated with nonscarring alopecia.10 Familial cases have also been described. 2 The eruptive disseminated type of syringomas (eruptive hidradenoma of Jaquet and Darier) is un¬ common. The lesions are numerous and typically ap¬ pear during adolescence in successive crops on the anterior aspects of the neck, chest, axillae, upper arms, abdomen, and groin.11 They are usually asymp¬ tomatic and tend to remain indefinitely, although they may eventually disappear.…”

Section: Discussionmentioning

confidence: 99%

An Eruption of Asymptomatic Brown Papules

Beers¹

1990

Arch Dermatol

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A 24-year-old woman presented for treatment of multiple skin lesions that appeared approximately 10 years previously. These began rather suddenly as asymptomatic "pimples" in the groin and axillary regions that erupted in crops over several years and remained unchanged. Over the previous few years, the lesions had increased in number and distribution. The patient was disturbed by their appearance. Her family history was remarkable for a sister with similar lesions, although not as extensive. The sister was not available for evaluation.Examination showed numerous discrete, darkbrown, flat-topped, smooth, 1-to 4-mm papules over the medial upper arms, lateral breasts, medial thighs, lower abdomen, and buttocks (Figs 1 through 3). The face, neck, axillary vault, and intertriginous aspects of the groin were spared.A biopsy specimen of a typical lesion is shown in Fig 4. What is your diagnosis? Figure 2.Figure 4. Downloaded From: http://archderm.jamanetwork.com/ by a Karolinska Institutet University Library User on 05/31/2015

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Familial syringoma. Case history and application of monoclonal anti-eccrine gland antibodies

Cited by 33 publications

References 6 publications

Cutaneous syringoma: A clinicopathologic study of 34 new cases and review of the literature

Cutaneous syringoma: A clinicopathologic study of 34 new cases and review of the literature

Autosomal dominant multiple syringomas linked to chromosome 16q22

An Eruption of Asymptomatic Brown Papules

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