Familial Solitary Fibrous Tumor of the Pleura

Jha, Vinayak; Gil, Joan; Teirstein, Alvin S.

doi:10.1378/chest.127.5.1852

Cited by 22 publications

(19 citation statements)

References 9 publications

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“…Environmental agents or genetically transmitted germline mutations may play a role in its etiology according to the literature, but no consistent chromosomal abnormality has been reported (9). Similar to 1 case in the current study, it has been reported that history of trauma can overshadow the exact pathogenesis (12).…”

Section: Discussionsupporting

confidence: 73%

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

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IntroductionPrimary tumors of the pleura are classified as diffuse and solitary. The solitary form was thought to be a form of mesothelioma and received different names such as localized mesothelioma, subpleural fibroma, benign mesothelioma, and subserous fibroma (1,2). It is recognized that the solitary fibrous tumor of the pleura (SFTP), which is rare and grows slowly, originates from mesenchymal cells of the submesothelial tissue of the pleura (3,4). No reports have demonstrated a correlation between SFTP and exposure to asbestos or any other carcinogens (5,6). Over 80% of these tumors are benign (1,4,7). They mostly appear between the 4th and 7th decades of life, half of them are asymptomatic, and they manifest as rounded, homogeneous masses with smooth margins on routine radiograms (8,9). Preoperative diagnosis is difficult because of nonspecific radiographic findings, and complete resection is the best prognostic factor (10-13).The aim of the present study was to identify any common or remarkable etiological factor or any biochemical abnormality or clinical presentation of SFTP, as well as to examine the best appropriate surgical approach and the results of long-term follow-up, and to compare these parameters with those reported in the literature. Materials and methodsBetween January 2001 and October 2014 the clinical and long-term follow-up records of 14 patients who had had surgery for SFTP were reviewed retrospectively. Common etiological factors, diagnostic procedures, and the clinical courses and outcomes for these patients were evaluated. The diagnosis of SFTP was confirmed by histomorphologic and immunohistochemical staining with hematoxylin/ eosin, CD34, vimentin, and cytokeratin. Malignancy criteria were described by England et al. (14) as more than 4 mitoses per 10 high-power fields, the presence of necrosis, and nuclear crowding and overlapping, which was defined as high cellularity and nuclear atypia. When one or more of these criteria was found histologically, the fibrous tumor was categorized as malignant (2,4). The classification of staging was based on de Perrot et al. Background/aim:The aim of the present study was to evaluate the etiology and clinical and pathological behavior of solitary fibrous tumors of the pleura (SFTPs), as well as the most appropriate surgical approach and the results of long-term follow-up of this condition.Materials and methods: Clinical and long-term follow-up records of 14 patients who had surgery for SFTP between 2001 and 2014 were reviewed retrospectively. Etiological factors, diagnostic procedures, and clinical courses and outcomes for these patients were studied.Results: Of the 14 patients, 8 were male (57%) and 6 were female (43%) patients. The mean age was 54.14 ± 10.35 (41-75) years. There was no remarkable common etiological factor. Preoperative diagnosis was achieved only in 2 patients. Predominant symptoms were cough and chest pain. Complete resection was achieved in all patients. Video-assisted thoracic surgery (VATS) was performed in 8 patients. All ...

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Section: Discussionsupporting

confidence: 73%

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

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“…To date, no evidences of a genetic predisposition or a relationship to exposure to asbestos or tobacco have been clearly demonstrated. Only one report of the occurrence of SFTP in family members has been published [41].…”

Section: Incidencementioning

confidence: 99%

Solitary fibrous tumors of the pleura

Cardillo

Lococo

Carleo

et al. 2012

Current Opinion in Pulmonary Medicine

102

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“…Only one report of the familial occurrence of SFTP in family members has been published, involving a mother and her daughter [24]. Generally, there is no evidence of correlation with genetic predisposition for the tumour, and there is no relationship to the exposure to asbestos, tobacco or any other environmental agents, although there are only two case reports of patients with SFTP who were exposed to asbestos and one patient developed an SFTP following thoracic irradiation for the treatment of chest wall keloid [25,26].…”

Section: Historymentioning

confidence: 99%

Solitary fibrous tumours of the pleura

Arab

2011

European Journal of Cardio-Thoracic Surgery

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SummarySolitary fibrous tumours of the pleura are rare. They are mesenchymal in origin. Initially, they were described in the pleura, but lately they have been reported in many other sites. Although the majority of these tumours are benign, some of them are malignant. Their unpredictable clinical course is probably related to their histological and morphological characteristics. The benign tumours may remain unproblematic for several years before changing into a malignant form. In order to define more accurately the clinical behaviour, diagnosis, management and outcome of these rare tumours, we reviewed the literature with particular attention to clinical presentation, methods of diagnosis, treatment and outcome. Furthermore, a modified algorithm was proposed for the management of these tumours.

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Familial Solitary Fibrous Tumor of the Pleura

Cited by 22 publications

References 9 publications

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

Solitary fibrous tumors of the pleura

Solitary fibrous tumours of the pleura

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