Familial pericentric inversion of chromosome 11 detected prenatally

Antenatal diagnosis of a de novo paracentric inversion of chromosome 11

“…Thirty-four reports have involved balanced, familial inversions. Fourteen were identified through prenatal diagnostic workups and the others through clinically abnormal probands (Ridler and Sutton, 1981 ;Russell et al, 1982). Indications for chromosome analyses were varied, ranging from multiple pregnancy losses to mental retardation and dysmorphia.…”