Familial Ocular Myopathy With Curare Sensitivity

Study of sensitivity to curare in certain neurological disorders using a regional technique.

“…There are reports of myasthenic defects in patients with amyotrophic lateral sclerosis (Mulder et al, 1959), in peripheral neuropathy (Baginsky, 1968), in myopathies (Ricker and Mertens, 1968;Simpson, 1974), and in myotonia (Isch-Treussard et al, 1968). Furthermore, undue sensitivity to curare has been noted on occasion in other than myasthenic disorders (Ross, 1963;Oosterhuis and de Haas, 1969;Mathew et al, 1970). Disorders which impair the structure and function of the nerve and muscle fibre might be expected to damage the adjacent neuromuscular junction.…”

Diagnostic problems in (ocular) myasthenia

“…curare) 4. Combined tests -measurement of intraocular pressure after administration of Tensilon -EMG of ocular muscle before and after administration of Tensilon slight transient sensitivity to Tensilon) and sensitivity to curare and decamethonium (Ross 1963(Ross , 1964Mathew et al, 1970;Jacob et al, 1966).…”

A regional technique for the study of sensitivity to curare in human muscle.

“…This has been most intensively studied in myasthenia gravis (Rowland et al, 1961). Excessive sensitivity can exist in other disorders: amyotrophic lateral sclerosis (Mulder et al, 1959), rheumatoid arthritis (Oosterhuis and de Haas, 1969), and ocular myopathy (Ross, 1963;Mathew et al, 1970) are among the conditions in which curare sensitivity has been reported, sometimes in the absence of previous muscular weakness or fatigue, while antibiotics may also increase curare sensitivity (Pittinger and Adamson, 1972 …”