Familial occurrence of testicular neoplasms (in cousins)

Madduri, Sivaprasad D.; Gellman, Alexander C.; Sporer, Andrew; Seebode, Joseph J.

doi:10.1016/0090-4295(79)90019-0

Cited by 12 publications

(1 citation statement)

References 17 publications

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“…(5) The occurrence of testicular tu mors in father and son [5,6], On the basis of these results and our own experience, we consider -in contrast to the opinion of other authors [2] -that in case of a testicular tumor disease an inves tigation (palpation, sonography, possibly tumor mark ers) or follow-up checks to rule out a testicular tumor, should be done not only in identical twins, but also in other relatives (nontwin brothers, fathers, sons etc.) [7,12,20],…”

Section: Discussionmentioning

confidence: 99%

Familial Occurrence of Testicular Cancer

Buerger¹,

Wallenberg²,

Reis³

et al. 1987

Urol Int

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A case of testicular cancer in 2 brothers is reported and a review of the literature about testicular malignancies and etiologic factors in closely related family members is given. The familial incidence of testicular tumor is found to be 3% in twins and 0.6–2.1 % in less closely related men. Tumors were of the same histology in 70–77% of the twins, whereas in brothers and in other degrees of relationship tumors of different histology mostly occur. Following the diagnosis of the tumor in the first man, the average interval to presentation of the tumor in the relative was 3.7 years in twins, 7.7 years in nontwin brothers and 13.5 years for less closely related men. The need for a thorough checkup of other family members is advised.

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Section: Discussionmentioning

confidence: 99%

Familial Occurrence of Testicular Cancer

Buerger¹,

Wallenberg²,

Reis³

et al. 1987

Urol Int

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Dizygotic twinning, cryptorchism, and seminoma in a sibship

Anderson

Marchetto

1984

Cancer

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Cryptorchism was diagnosed in all 3 male members of 2 pairs of dizygotic twins in a sibship. Two of these brothers developed seminomas at age 31 and 33 years. Studies revealed a nephew with an atrophic testicle, but no additional instances of twinning, cryptorchism or testis cancer. Cryptorchism has been reported previously in 3 of 8 sets of twins with testis cancer, but rarely in familial testis cancer affecting other relatives. Hormonal factors may be involved in the association of twinning, cryptorchism and testis cancer in this family.

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Familial testicular cancer and urogenital developmental anomalies

Tollerud

Blattner

Fraser

et al. 1985

Cancer

106

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In a case‐control study of testicular cancer, 6 of 269 cases (2.2%) reported a first‐degree relative with testicular cancer, compared to 1 of 259 controls (0.4%). Fathers and brothers of testicular cancer cases had a six‐fold elevated risk of developing a testicular malignancy compared to men in the general population. Cryptorchidism was reported in a first‐degree relative in 1 (17%) of the familial cases versus 7 of 259 (2.7%) controls and 14 of 263 (5.3%) cases with a negative family history for testicular cancer. One half of the 6 familial cases reported a first‐degree relative with a groin hernia (all surgically repaired before age 12), compared to 12.7% of 259 controls and 10.3% of 263 nonfamilial cases. Three familial clusters identified through the case‐control study were selected for clinical evaluation. One of the 6 surviving males with testicular cancer in these 3 families had undergone orchiopexy and inguinal herniorrhaphy at age 6 years, and one had a hydrocele associated with his testicular tumor. Of the 12 living fathers and brothers of these 6 men, 3 reported childhood inguinal hernias, two with coexisting hydroceles. One additional hernia and two additional hydroceles were detected during urologic evaluation of these healthy relatives. The high prevalence of cryptorchidism, inguinal hernias, and hydroceles among men in these families suggests that an underlying alteration in urogenital embryogenesis may be associated with the familial predisposition to testicular neoplasia.

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Familial occurrence of testicular neoplasms (in cousins)

Cited by 12 publications

References 17 publications

Familial Occurrence of Testicular Cancer

Familial Occurrence of Testicular Cancer

Dizygotic twinning, cryptorchism, and seminoma in a sibship

Familial testicular cancer and urogenital developmental anomalies

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