Familial occurrence of cluster headache.

Russell, Michael Bjørn; Andersson, Poul Gertz; Thomsen, Laura H.

doi:10.1136/jnnp.58.3.341

Cited by 105 publications

(79 citation statements)

References 23 publications

(5 reference statements)

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“…No family history emerged for either patient, although a genetic risk for cluster headache has been described [27,28].…”

Section: Discussionmentioning

confidence: 95%

Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Gallai¹,

Mazzotta²,

Floridi³

et al. 2003

J Headache Pain

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A multicenter one-year study was carried out on 6629 headache patients under 18 years of age, attending 27 centers and clinics devoted to headache in Italy to identify the prevalence of cluster headache (CH) in childhood and adolescence. Two male CH patients aged 9 and 17 years were identified. Their attacks fulfilled the IHS criteria for CH, and they were classified as having cluster headache with undetermined periodicity and episodic cluster headache, respectively. The one-year prevalence in this headache out-patient population under 18 years of age was calculated to be 0.03%. This value is smaller than that derived in the general population. This finding further confirms the rarity of early diagnosis of this primary disorder in childhood and adolescence, as demonstrated in other studies.

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“…No family history emerged for either patient, although a genetic risk for cluster headache has been described [27,28].…”

Section: Discussionmentioning

confidence: 95%

Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Gallai¹,

Mazzotta²,

Floridi³

et al. 2003

J Headache Pain

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show abstract

“…CH has a prevalence of up to 0.1%,2 and is three times more common in men than in women 1. An increasing number of studies show a genetic contribution to CH, and 7%‐20% of the patients have a positive family history, defined as having at least one first‐, second‐, or third‐degree relative also diagnosed with CH 3, 4. The causes of CH and those factors that might trigger the onset of an active period are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Screening of Two ADH4 Variations in a Swedish Cluster Headache Case–Control Material

et al. 2016

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BackgroundCluster headache (CH) is a severe neurovascular disorder and an increasing amount of evidence points to a genetic contribution to this disease. When CH was first described, it was observed that alcohol may precipitate an attack during the active phase of the disease. The alcohol dehydrogenase 4 (ADH4) gene encodes an enzyme which contributes to the metabolization of alcohol and is, therefore, an interesting candidate gene for CH. Two Italian groups have reported association of the single nucleotide polymorphism (SNP) rs1126671 located in the ADH4 gene with an increased risk of CH in Italy. In addition, one of the groups found an association between the ADH4 SNP rs1800759 and CH.ObjectiveTo perform a replication study on the ADH4 SNPs rs1126671 and rs1800759 in a large homogeneous Swedish case–control cohort in order to further investigate the possible contribution of ADH4 to CH.MethodsA total of 390 unrelated patients diagnosed with CH and 389 controls representing a general Swedish population were recruited to the study. DNA samples from patients and controls were genotyped for the two ADH4 SNPs rs1126671 and rs1800759 using quantitative real‐time polymerase chain reaction. Statistical analyses of genotype, allele and haplotype frequencies for the two SNPs were performed and compared between patients and controls.ResultsFor rs1126671, the minor allele frequency (A allele) was 32.8% (n = 254) in controls compared with 31.9% (n = 249) in CH patients. The minor allele frequency (A allele) of rs1800759 was 42.3% (n = 324) in controls and 41.9% (n = 327) in CH patients. Statistical analysis showed no significant differences in allele as well as in genotype or haplotype frequencies between the patient and control group for either SNP. This was also seen after stratifying the patient group for experiencing alcohol as a trigger factor.ConclusionsThe data did not support an association of the ADH4 SNPs rs1126671 and rs1800759 with CH. A comparison with previous studies revealed variance in genotype, allele, and haplotype frequencies among the different populations which might contribute to the contradictory results. Although a significant association with CH in Swedish case–control group was not found, ADH4 as a candidate gene for CH could not be excluded.

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“…This may affect the representativeness of the study population. However, most likely it only has minor significance, since 92% (24/26) of the affected relatives alive had at some time consulted a physician and/or a neurologist because of their cluster headache [15]. This is a much higher consultation rate than found among migraineurs (56%) and tension-type headache sufferers (16%) [19].…”

Section: Cluster Headachementioning

confidence: 98%

“…The literature provides more complete information in four genetic epidemiological studies [14][15][16][17][18]. The first study, a Danish genetic epidemiological survey, included 370 probands [14,15].…”

Section: Cluster Headachementioning

confidence: 99%

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Familial occurrence in primary headaches

Russell

2001

J Headache Pain

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This paper reviews the literature of genetic epidemiology in primary headaches. Migraine without aura and migraine with aura are distinct disorders. Both are caused by a combination of genetic and environmental factors. Tension–type headache . The episodic form is most likely non–genetic, while the chronic form is caused by a combination of genetic and environmental factors. Cluster headache has previously not been thought to be genetic. However, first degree relatives of cluster headache sufferers have a 14–46 fold significantly increased risk of cluster headache, compared to the general population.

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Familial occurrence of cluster headache.

Cited by 105 publications

References 23 publications

Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Screening of Two ADH4 Variations in a Swedish Cluster Headache Case–Control Material

Familial occurrence in primary headaches

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