Familial nephropathy in Bracchi Italiani: 8 cases (2012–2019)

Abstract

OBJECTIVE To characterize the signalment, clinical signs, clinical pathological and histologic findings, and outcome in 8 related Bracchi Italiani with proteinuric kidney disease. ANIMALS 8 client-owned Bracchi Italiani. PROCEDURES Health records submitted to the Bracco Italiano Health Foundation and the Bracco Italiano Club of America between 2012 and 2019 were reviewed for dogs with evidence of nephropathy for which histologic diagnoses were obtained. Pedigree, signalment, clinical signs, diagnostic test results (including microscopic examination of kidney tissue samples collected ante- or postmortem), and outcome were acquired. Results were presented as descriptive statistics. RESULTS The most common clinical sign in affected dogs was inappetence. All dogs were proteinuric, and 4 dogs were azotemic. Seven dogs developed clinical signs of kidney disease and were euthanized a median of 75 days postdiagnosis. Six dogs had glomerular amyloidosis, and 1 dog each had nephrosclerosis and nonamyloidotic fibrillar glomerulopathy. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that the clinical presentation may vary in affected dogs, and proteinuria in young or middle-aged Bracchi Italiani should raise the concern for hereditary nephropathy. Prognosis is likely poor once clinical signs are noted.

Renal amyloid‐A amyloidosis in cats: Characterization of proteinuria and biomarker discovery, and associations with kidney histology

“…Furthermore, an association was observed between the presence of renal AA amyloidosis and renal lesions in cats, and in particular glomerulosclerosis and fibrosis. In previous studies in dogs and cats with familial AA amyloidosis and kidney involvement, several lesions were observed, including glomerulosclerosis, fibrosis, interstitial nephritis, tubular atrophy, and obsolescent glomeruli 8,31,32 . Nonetheless, in none of these studies was an association with AA amyloidosis explored.…”

“…In previous studies in dogs and cats with familial AA amyloidosis and kidney involvement, several lesions were observed, including glomerulosclerosis, fibrosis, interstitial nephritis, tubular atrophy, and obsolescent glomeruli. 8 , 31 , 32 Nonetheless, in none of these studies was an association with AA amyloidosis explored. Based on our results, and despite the limited number of cases included in our case series, strategies to prevent and treat AA amyloidosis might be recommended in affected cats to avoid or slow the progression of renal disease.…”

“…In previous studies in dogs and cats with familial AA amyloidosis and kidney involvement, several lesions were observed, including glomerulosclerosis, fibrosis, interstitial nephritis, tubular atrophy, and obsolescent glomeruli. 8,31,32 Nonetheless, in none of these studies was an association with AA amyloidosis explored. promoting glomerulosclerosis and fibrosis.…”

Amiloidose Renal Familiar Em Dois Cães Da Raça Shar-Pei

“…Em relatos de Sonne et al ( 2), Júnior et al (11) e Loewen et al (8), os cães também da mesma raça, apresentavam prostração, anorexia, vômitos, diarreia, edema de membros, poliúria, polidpsia e em alguns casos anúria. O estudo Inman et al (9), teve como um dos objetivos avaliar os sinais clínicos de 8 cães Braco-italianos, e desses, cerca de 6 apresentavam amiloidose renal com sinais de inapetência, poliúria, polidpsia e perda de peso. No presente relato, os tutores procuraram por atendimento veterinário após a constatação da presença de vômitos, emagrecimento progressivo e inapetência, estando em partes associado ao descrito por Animais portadores de amiloidose podem apresentar achados laboratoriais variados a depender da progressão e severidade de DRC associada.…”

“…No presente relato, os tutores procuraram por atendimento veterinário após a constatação da presença de vômitos, emagrecimento progressivo e inapetência, estando em partes associado ao descrito por Animais portadores de amiloidose podem apresentar achados laboratoriais variados a depender da progressão e severidade de DRC associada. De forma geral, azotemia, proteinúria, alterações eletrolíticas, hematológicas e bioquímicas, e modificações na urinálise como proteinúria de intensidade variável, alterações na concentração do filtrado, incremento na RPCU, sedimento inativo, entre outras (2,8,9,11). No presente relato, os animais apresentavam proteinúria (2+ e 3+), pH 5, densidade urinária de 1,024 e 1,026, e azotemia.…”