Familial nasopharyngeal carcinoma

Zeng, Yi Xin; Jia, Wei Hua

doi:10.1016/s1044579x02000871

Cited by 81 publications

(74 citation statements)

References 34 publications

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“…In that study, an average of 4 -5 cases of NPC were observed in each family, and the average age of patients at diagnosis was 35.52 years-much younger than the average age of onset for sporadic cases diagnosed in outpatients at CCSYSU (46.6 years). 35 In the current study, the average age of onset decreased from 44.48 years to 40.43 years as the number of cases of NPC per family increased from 1 to 4, although the absolute trend did not achieve statistical significance. In Taiwan, a moderate-risk area with respect to NPC, a study conducted by Ung et al 30 (involving 25 familial cases and 350 sporadic cases) found no significant difference between familial cases and sporadic cases in terms of age, ethnicity, disease histology, disease stage, or family history of other malignancies.…”

Section: Discussioncontrasting

confidence: 61%

“…Although little information on NPC is available in the literature, there is some evidence that other malignancies, such as salivary gland carcinomas and Burkitt lymphoma, may be associated with the development of NPC. 35 However, these malignancies all can be traced to the involvement of EBV in NPC pathogenesis. In the current study, we examined the occurrence of other malignancies in FDRs of probands with NPC in a high-risk subgroup and found no significantly increased risks.…”

Section: Discussionmentioning

confidence: 99%

“…[27][28][29][30][31][32][33][34][35] One reported family living in Nanhai County of Guangdong Province has 15 family members affected with NPC, 2 family members affected with hepatic cell carcinomas, and 1 family member with breast carcinoma. In southern Chinese populations, several case-control studies have confirmed that the proportion of NPC cases with positive first-degree family history is Ͼ 5%, with similar proportions found in high-risk areas such as Hong Kong (7.2%), Yulin (6.0%), and Guangzhou (5.9%).…”

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confidence: 99%

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Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China

Jia

Feng

et al. 2004

Cancer

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BACKGROUNDPrevious studies have suggested that genetic susceptibility may play an important role in the etiology of nasopharyngeal cancer (NPC). However, to date, few large‐scale studies have been conducted on familial risk and clustering of NPC in a high‐risk area of China.METHODSIn the current study, 2252 patients with NPC who were treated at the Cancer Center of Sun Yat‐Sen University in Guangdong Province, China, were identified as probands. Family histories of NPC and other malignancies were observed in first‐degree relatives (FDRs) and second‐degree relatives, and other information was obtained through interviews. One thousand nine hundred and three Cantonese families were selected for further investigation. To assess familial aggregation, the authors used standardized incidence ratios (SIRs) to measure the risk of NPC for FDRs and compared the observed number of cases with the number predicted by population‐based frequencies in the Cantonese population of Hong Kong.RESULTSThe current analysis indicated that families with ≥ 3 relatives who had NPC were distributed predominantly among a high‐risk subgroup of the Cantonese population in Guangdong Province and that the frequency of these families was 0.68%. An SIR of 2.09 (95% confidence interval [CI], 1.80–2.40) was observed among 13,833 FDRs in the high‐risk subgroup, and a significantly elevated risk for NPC was observed in FDRs of probands with early age of onset (age < 40 years; SIR, 9.01 [95% CI, 6.10–13.30]). Furthermore, decreased risks of hepatic, lung, esophageal, gastric, and breast carcinoma, as well as malignancy of all sites, were observed among FDRs of probands with NPC when Hong Kong and Shanghai populations were used as reference groups.CONCLUSIONSNPC tends to aggregate in Cantonese families in Guangdong Province, and the malignancies in these families appear to be site specific, with no excess of any other malignancy. Cancer 2004. © 2004 American Cancer Society.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China

Jia

Feng

et al. 2004

Cancer

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“…NPC has a particularly high incidence in Southeast Asia and Northern Africa, with a distinct ethnic predilection (Chou et al, 2008). Accumulating evidence revealed that NPC is a multifactorial malignancy associated with Epstein-Barr virus (EBV) infection, genetic susceptibility and environmental factors (McDermott et al, 2001;Zeng and Jia, 2002;Wei and Sham, 2005;Bei et al, 2010). Although NPC tumors are sensitive to radiotherapy and chemotherapy, the prognosis is poor due to recurrence and metastases.…”

Section: Introductionmentioning

confidence: 99%

MiR-663, a microRNA targeting p21WAF1/CIP1, promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma

et al. 2012

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“…The disease models underpinning multiple familial cancers such as familial nasopharyngeal carcinoma, 112 familial testicular germ cell tumor, 113 familial chronic lymphocytic leukemia, 114 and familial colorectal cancer (familial colorectal cancer type X) 29 remain contentious as the high-penetrance mutations are yet to be identified. By contrast, multiple low-penetrance variants that confer an effect size of odds ratio o1.5 have been revealed through genome-wide association studies for the sporadic cases of these cancers; interestingly, some of these single-nucleotide polymorphisms have also been found to be associated with the familial cases (nasopharyngeal carcinoma, 115 testicular germ cell tumor, 116,117 chronic lymphocytic leukemia, 118,119 and colorectal cancer 120 ).…”

Section: Perspectives and Conclusionmentioning

confidence: 99%

Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X

Cooper

et al. 2012

Modern Pathology

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Recent advances in genotyping and sequencing technologies have provided powerful tools with which to explore the genetic basis of both Mendelian (monogenic) and sporadic (polygenic) diseases. Several hundred genomewide association studies have so far been performed to explore the genetics of various polygenic or complex diseases including those cancers with a genetic predisposition. Exome sequencing has also proven very successful in elucidating the etiology of a range of hitherto poorly understood Mendelian disorders caused by high-penetrance mutations. Despite such progress, the genetic etiology of several familial cancers, such as familial colorectal cancer type X, has remained elusive. Familial colorectal cancer type X and Lynch syndrome are similar in terms of their fulfilling certain clinical criteria, but the former group is not characterized by germline mutations in DNA mismatch-repair genes. On the other hand, the genetics of sporadic colorectal cancer have been investigated by genome-wide association studies, leading to the identification of multiple new susceptibility loci. In addition, there is increasing evidence to suggest that familial and sporadic cancers exhibit similarities in terms of their genetic etiologies. In this review, we have summarized our current knowledge of familial colorectal cancer type X, discussed current approaches to probing its genetic etiology through the application of new sequencing technologies and the recruitment of the results of colorectal cancer genome-wide association studies, and explore the challenges that remain to be overcome given the uncertainty of the current genetic model (ie, monogenic vs polygenic) of familial colorectal cancer type X.

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Familial nasopharyngeal carcinoma

Cited by 81 publications

References 34 publications

Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China

Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China

MiR-663, a microRNA targeting p21WAF1/CIP1, promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma

Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X

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